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Label-free high-throughput optical technique for detecting biomolecular interactions

  • US 7,202,076 B2
  • Filed: 10/23/2001
  • Issued: 04/10/2007
  • Est. Priority Date: 10/30/2000
  • Status: Expired due to Fees
First Claim
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1. A biosensor composition comprising one or more biosensors on a tip of a multi-fiber optic probe, wherein the biosensors comprise:

  • (i) a two-dimensional grating;

    (ii) a substrate that supports the two-dimensional grating;

    wherein the refractive index of the two-dimensional grating is greater than the refractive index of the substrate; and

    (iii) one or more specific binding substances immobilized on the surface of the two-dimensional grating opposite of the substrate layer;

    wherein when the biosensor is illuminated a resonant grating effect is produced on a reflected radiation spectrum, and wherein the depth and period of the two-dimensional grating are less than the wavelength of the resonant grating effect.

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