Label-free high-throughput optical technique for detecting biomolecular interactions
First Claim
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1. A biosensor composition comprising one or more biosensors on a tip of a multi-fiber optic probe, wherein the biosensors comprise:
- (i) a two-dimensional grating;
(ii) a substrate that supports the two-dimensional grating;
wherein the refractive index of the two-dimensional grating is greater than the refractive index of the substrate; and
(iii) one or more specific binding substances immobilized on the surface of the two-dimensional grating opposite of the substrate layer;
wherein when the biosensor is illuminated a resonant grating effect is produced on a reflected radiation spectrum, and wherein the depth and period of the two-dimensional grating are less than the wavelength of the resonant grating effect.
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Abstract
Methods and compositions are provided for detecting biomolecular interactions. The use of labels is not required and the methods can be performed in a high-throughput manner. The invention also provides optical devices useful as narrow band filters.
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7 Claims
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1. A biosensor composition comprising one or more biosensors on a tip of a multi-fiber optic probe, wherein the biosensors comprise:
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(i) a two-dimensional grating; (ii) a substrate that supports the two-dimensional grating;
wherein the refractive index of the two-dimensional grating is greater than the refractive index of the substrate; and(iii) one or more specific binding substances immobilized on the surface of the two-dimensional grating opposite of the substrate layer;
wherein when the biosensor is illuminated a resonant grating effect is produced on a reflected radiation spectrum, and wherein the depth and period of the two-dimensional grating are less than the wavelength of the resonant grating effect. - View Dependent Claims (2, 3, 4, 5, 6, 7)
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Specification