Optically similar reference samples
First Claim
1. A method of characterizing the performance of an infrared spectroscopic system, comprising:
- a. providing a reference sample comprising a gelling agent;
a scattering agent that scatters infrared energy; and
water;
b. using the infrared spectroscopic system to measure the response of the reference sample to incident radiation;
c. characterizing the performance of the infrared spectroscopic system from a comparison of the measured response with a response expected from the known properties of the reference sample.
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Abstract
Systems and methods for establishing and/or maintaining the accuracy of a multivariate calibration model designed for quantitative optical spectroscopic measurement of attributes or analytes in bodily tissues, bodily fluids or other biological samples, which are particularly useful when the spectral absorbance of the attribute or analyte is small relative to the background. The present invention provides an optically similar reference sample to reduce the effect of instrument or environment variation on the measurement capability of the model. The optically similar reference can be a gel composition having scattering particles suspended therein. The reference gel can be directly applied to a spectroscopic instrument sampler, or can be in a container specifically designed for optimal coupling to a spectroscopic instrument.
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Citations
47 Claims
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1. A method of characterizing the performance of an infrared spectroscopic system, comprising:
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a. providing a reference sample comprising a gelling agent;
a scattering agent that scatters infrared energy; and
water;b. using the infrared spectroscopic system to measure the response of the reference sample to incident radiation; c. characterizing the performance of the infrared spectroscopic system from a comparison of the measured response with a response expected from the known properties of the reference sample. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47)
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Specification