Multi-modal system for detection and control of changes in brain state

• US 7,204,833 B1
• Filed: 08/02/2004
• Issued: 04/17/2007
• Est. Priority Date: 10/11/2002
• Status: Active Grant

• Current Assignee: Flint Hills Scientific, LLC
• Original Assignee: Flint Hills Scientific, LLC
• Inventors: Osorio, Ivan, Bhavaraju, Naresh C.
• Primary Examiner(s): GIBSON, ROY DEAN
• Application Number:
  US10/909,488
• Time in Patent Office: 988 Days
• Field of Search: 604/95, 604/113, 606 20- 26, 607104-106, 607113-114
• US Class Current: 606/22
• CPC Class Codes: A61B 5/031 Intracranial pressure
• CPC Class Codes: A61B 5/14553 specially adapted for cerebral tissue
• CPC Class Codes: A61B 5/291 for electroencephalography [EEG]
• CPC Class Codes: A61B 5/293 Invasive
• CPC Class Codes: A61B 5/4094 Diagnosing or monitoring seizure diseases, e.g. epilepsy
• CPC Class Codes: A61F 2007/0056 for cooling
• CPC Class Codes: A61F 2007/0075 using a Peltier element, e.g. near the spot to be heated or cooled
• CPC Class Codes: A61F 7/12 Devices for heating or cooling internal body cavities

Abstract

A multi-purpose device mechanism for sensing and control of changes in brain state includes a shaft portion and extendible elements structured for insertion into target tissue of the brain of a subject patient, cooling means configured to operatively apply cooling therapy to the target tissue, stimulation means having at least one electrical contact structured to operatively apply electrical stimulation therapy to the target tissue, sensing means including at least one sensor monitoring a biological signal of the subject patient, control means responsive to the sensing means wherein the control means is structured to, in response to signals from the sensing means that indicate the presence of a pre-determined physiological condition or occurrence of an undesirable state change, automatically cause the cooling means and/or the stimulation means to initiate or terminate the cooling therapy and/or the electrical stimulation therapy respectively and an energy source for powering the various components of the multi-purpose device mechanism. A modified embodiment includes a least one spiral conduit and at least one return conduit for cycling coolant or refrigerant to and from the shaft portion and an external reservoir. Another modified embodiment includes pressurizing means for extending at least one extendable tube into brain tissue surrounding the shaft portion.

Claims

1. A device for control of tissue temperature in three dimensions, comprising;

(a) a shaft portion having a distal end, wherein the shaft portion is structured for insertion into target tissue of a subject patient;

(b) cooling means structured to change temperature within the target tissue, wherein the cooling means includes;

(1) at least one cluster of conduits spaced inside the shaft portion and extending out of the shaft portion at a first distance from a surface of the tissue, wherein each conduit of the at least one cluster of conduits is structured to carry extendable wires or tubes into the target tissue;

(2) advancing means structured to selectively advance the at least one extendable wires or tubes through the conduits of the at least one cluster of conduits into brain tissue surrounding the shaft portion.

2. The device as described in claim 1, wherein the at least one cluster of conduits includes a plurality of clusters of conduits to facilitate insertion of wires or tubes into the tissue surrounding the shaft portion.

3. The device as described in claim 1, wherein at least one cluster of conduits open into the tissue surrounding the shaft portion at a second distance from a surface of the tissue, wherein the second distance is different from the first distance.

4. The device as described in claim 1, wherein the conduits of the at least one cluster of conduits open into the surrounding tissue at any desirable angle with respect to the axis of the shaft portion.

5. The device as described in claim 1, wherein the control means is structured to provide cooling and electrical stimulation.

6. The device as described in claim 1, further configured to enable delivery of chemicals or drugs into tissue into different locations in three dimensions, further comprising;

(a) pumping means configured to pump at least one desired drug or chemical, wherein the pumping means includes;

(1) at least one extendable tube housed within the shaft portion and structured to be extended outwardly from the shaft portion, and

(2) advancing means structured to advance the at least one extendable tube into brain tissue surrounding the shaft portion;

(b) control means structured to regulate the flow of the drug or chemical into or through the shaft and/or at least one extendable tube into the target tissue; and

(c) an energy source for powering the various components of the device.

7. The device as described in claim 6, further comprising:

(a) sensing means including at least one sensor monitoring a biological signal of the subject patient; and

(b) wherein the control means are configured to detect or predict a change in the biological signal that is indicative of the occurrence of a change of state and, in response thereto, to automatically deliver a prespecified amount of drug or chemical into the target tissue.

8. The device as described in claim 6, wherein, the drug or chemical can be cooled to a desired temperature and the temperature of the target tissue can be controlled.

9. The device as described in claim 6, wherein delivery of the drug or chemical occurs through a the distal end of the shaft portion.

10. A device for control of tissue temperature in three dimensions, comprising;

(a) a shaft portion structured for insertion into target tissue of a subject patient;

(b) an external reservoir containing coolant or refrigerant;

(c) cooling means configured to change temperature within the target tissue, wherein the cooling means includes;

(1) a least one inflow conduit structured to carry coolant or refrigerant from the reservoir to and through the shaft portion, the at least one inflow conduit having a spiral shape; and

(2) at least one return conduit structured to carry coolant or refrigerant from the at least one inflow conduit to the reservoir;

(d) control means structured to control the flow of coolant or refrigerant through the at least one inflow and/or return conduits; and

(e) an energy source for powering the various components of the device.

11. A device for control of tissue temperature in three dimensions, comprising;

(a) a shaft portion structured for insertion into target tissue of a subject patient;

(b) an external reservoir containing coolant or refrigerant;

(c) cooling means configured to change temperature within the target tissue, wherein the cooling means includes;

(1) a least one inflow conduit structured to carry coolant or refrigerant from the reservoir to and through the shaft portion, the at least one inflow conduit including two spiral conduits intertwined in a double helix configuration; and

(2) at least one return conduit structured to carry coolant or refrigerant from the at least one inflow conduit to the reservoir, the at least one return conduit being located inside the two spiral conduits to provide a return path to the reservoir for the coolant or refrigerant carried by the two spiral conduits;

(d) control means structured to control the flow of coolant or refrigerant through the at least one inflow and/or return conduits; and

(e) an energy source for powering the various components of the device.

12. A device for control of tissue temperature in three dimensions, comprising;

(a) a shaft portion structured for insertion into target tissue of a subject patient;

(b) an external reservoir containing coolant or refrigerant;

(c) cooling means configured to change temperature within the target tissue, wherein the cooling means includes;

(1) at least one inflow conduit structured to carry coolant or refrigerant from the reservoir to and through the shaft portion, the at least one inflow conduit including two spiral conduits having a double helix configuration; and

(2) at least one return conduit structured to carry coolant or refrigerant from the at least one inflow conduit to the reservoir, the at least one return conduit including two separate return conduits positioned within the two spiral conduits to provide separate return paths to the reservoir for the coolant or refrigerant carried by the two spiral conduits;

(d) control means structured to control the flow of coolant or refrigerant through the at least one inflow and/or return conduits; and

(e) an energy source for powering the various components of the device.