Shaped microcomponents via reactive conversion of biologically-derived microtemplates

• US 7,204,971 B2
• Filed: 05/30/2002
• Issued: 04/17/2007
• Est. Priority Date: 05/30/2001
• Status: Expired due to Fees

• Current Assignee: Ohio State University
• Original Assignee: Ohio State University
• Inventors: Sandhage, Kenneth H.
• Primary Examiner(s): Wityshyn; Michael G.
• Assistant Examiner(s): Ford; Allison M.
• Application Number:
  US10/160,292
• Publication Number:
  US 20030039693A1
• Time in Patent Office: 1,783 Days
• Field of Search: 977/1, 423/325, 423/335, 423/339, 423/155, 423/179, 423/111, 423/69, 435/71.1
• US Class Current: 423/592.1
• CPC Class Codes: B81B 2201/034 Electrical rotating micromachines
• CPC Class Codes: B81B 2201/035 Microgears
• CPC Class Codes: B81C 1/00 Manufacture or treatment of devices or systems in or on a substrate B81C3/00 takes precedence
• CPC Class Codes: B81C 99/0085 using moulds and master templates, e.g. for hot-embossing
• CPC Class Codes: G01N 33/54346 Nanoparticles
• CPC Class Codes: G01N 33/54353 with ligand attached to the carrier via a chemical coupling agent coatings G01N33/54393
• CPC Class Codes: G01N 33/544 the carrier being organic
• CPC Class Codes: Y10S 977/811 Of specified metal oxide composition, e.g. conducting or semiconducting compositions such as ITO, ZnOx
• CPC Class Codes: Y10S 977/84 Manufacture, treatment, or detection of nanostructure
• CPC Class Codes: Y10S 977/89 Deposition of materials, e.g. coating, cvd, or ald
• CPC Class Codes: Y10S 977/90 having step or means utilizing mechanical or thermal property, e.g. pressure, heat

Abstract

The present invention is focused on a revolutionary, low-cost (highly-scaleable) approach for the mass production of three-dimensional microcomponents: the biological reproduction of naturally-derived, biocatalytically-derived, and/or genetically-tailored three-dimensional microtemplates (e.g., frustules of diatoms, microskeletons of radiolarians, shells of mollusks) with desired dimensional features, followed by reactive conversion of such microtemplates into microcomponents with desired compositions that differ from the starting microtemplate and with dimensional features that are similar to those of the starting microtemplate. Because the shapes of such microcomponents may be tailored through genetic engineering of the shapes of the microtemplates, such microcomposites are considered to be Genetically-Engineered Materials (GEMs).

Claims

1. A method of producing a shaped microcomponent, comprising:

a) depositing a silaffin into a pattern, said pattern having an original dimensional feature;

b) exposing said patterned silaffin to a silicon-containing solution to generate a silica microtemplate, said silica microtemplate having substantially the same dimensional feature as said patterned silaffin;

then

c) subjecting said silica microtemplate to at least one chemical reaction with a metal, so as to at least partially convert said silica microtemplate into a shaped microcomponent comprising a solid oxide,

wherein said chemical reaction effects replacement of silicon with a metal ion and is selected from the group consisting of additive reactions, metathetic reactions, oxidation-reduction reactions, and combinations thereof; and

wherein said shaped microcomponent has substantially the same dimensional feature as said silica microtemplate.

2. The method of claim 1, wherein said silaffin is derived from a genetically altered organism.

3. The method of claim 1, wherein said silaffin is derived from an organism selected from the group consisting of:

organisms with a hard endoskeleton, organisms with a soft endoskeleton, organisms with a hard exoskeleton, organisms with a soft exoskeleton, organisms with a portion of a hard endoskeleton, organisms with a portion of a soft endoskeleton, organisms with a portion of a hard exoskeleton, and organisms with a portion of a soft exoskeleton.

4. The method of claim 1, wherein said chemical reaction is an oxidation-reduction reaction of the type:

yA+aM_xO_z→

yAO_za/y+axM

wherein A is the metal reactant, M_xO_z is the silica of the silica microtemplate, AO_za/y is the solid oxide of the shaped microcomponent, and M is a second reaction product; and

wherein y, a, x, and z are stoichiometric coefficients.

5. The method of claim 4, wherein the solid oxide AO_za/y is selected from the group consisting of lithium oxide, beryllium oxide, magnesium oxide, aluminum oxide, calcium oxide, titanium oxide, strontium oxide, yttrium oxide, zirconium oxide, antimony oxide, barium oxide, lanthanum oxide, hafnium oxide, cerium oxide, neodymium oxide, praseodymium oxide, samarium oxide, europium oxide, gadolinium oxide, dysprosium oxide, holmium oxide, erbium oxide, thulium oxide, lutetium oxide and ytterbium oxide.

6. The method of claim 1, wherein said shaped microcomponent defines a cavity wherein said cavity is provided with at least one substance.

7. The method of claim 6, wherein said at least one substance is a pharmaceutically active substance.

8. The method of claim 1, wherein said shaped microcomponent possesses a shape selected from the group consisting of a solid microcylinder, a microtube, a solid microbar, a hollow microbar, a solid microsphere, a hollow microsphere, a solid microdisk, a hollow microdisk, a microwheel, a microgear, a microrotor, a microplate, a microtetrahedron, a microwedge, a microtetrakaidecahedron, a microspring, a microspiral, a microlever, a microcantilever, a solid microcone, a microfunnel, a microhoneycomb, a micromesh, a solid microcube, a hollow microcube, a solid microfiber, a hollow microfiber, and combinations thereof.

9. The method of claim 1, wherein said shaped microcomponent comprises a part of a device selected from the group consisting of a micro-pump, a micro-valve, a micro-funnel, a micro-nozzle, a micro-reactor, a micro-bearing, a micro-pulley, a micro-turbine engine, a micro-rocket, a micro-piston engine, a micro-motor, a micro-actuator, a micro-switch, a micro-transducer, a micro-hinge, a micro-cantilever, a micro-relay, a micro-die, a micro-sensor, a micro-catalyst, a micro-syringe, a micro-needle, a microcapsule, a micro-sieve, a micro-filter, a micro-membrane, a micro-separator, a micro-mirror, a micro-lens, a micro-prism, a micro-diffraction grating, a micro-refraction grating, a micro-antenna, a micro-magnet, a micro-tag, a micro-fiber, a micro-light pipe, a micro-mixer, a micro-heat exchanger, a micro-insulator, a micro-substrate, a micro-filler, and combinations thereof.

10. The method of claim 1 wherein said shaped microcomponent possesses at least one dimensional feature that is less than 1 millimeter in size.

11. The method of claim 1 wherein said shaped microcomponent possesses at least one dimensional feature that is less than 100 microns in size.

12. The method of claim 1 wherein said shaped microcomponent possesses at least one dimensional feature that is less than 25 microns in size.

13. The method of claim 1 wherein said shaped microcomponent possesses at least one dimensional feature that is less than 10 microns in size.

14. The method of claim 1 wherein said shaped microcomponent possesses at least one dimensional feature that is less than 1 microns in size.

15. The method of claim 1 wherein said shaped microcomponent possesses at least one dimensional feature that is less than 100 nanometers in size.

16. The method of claim 1 wherein said shaped microcomponent possesses at least one dimensional feature that is less than 25 nanometer in size.

17. The method of claim 1 wherein said shaped microcomponent possesses at least one dimensional feature that is less than 10 microns in size.