Method and apparatus for modifying delivery of a therapy in response to onset of sleep
First Claim
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1. An implantable medical device capable of being implanted in a patient, comprising:
- a therapy component configured to provide a therapy to the patient;
sensing circuitry sensing a physiologic parameter corresponding to minute ventilation values indicative of a minute ventilation of the patient; and
a microprocessor coupled to the therapy component and the sensing circuitry to detect onset of a first state of the patient in response to the sensed physiologic parameter, and to determine whether the onset of the first state is detected for a first predetermined time period, wherein the first state corresponds to an asleep state, andwherein the microprocessor receives a plurality of the minute ventilation values at predetermined time intervals over a period of time to generate a first distribution rate of minute ventilation values of the plurality of minute ventilation values received during first time intervals m of the predetermined time intervals, including a current time interval and first preceding time intervals m-1, and a second distribution rate of minute ventilation values received during second time intervals n of the predetermined time intervals, including the current time interval and second preceding time intervals n1, wherein the onset of the first state is detected in response to the second distribution rate being greater than the first distribution rate.
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Abstract
A method and apparatus for providing a therapy to the patient that includes a therapy component configured to provide the therapy to the patient, sensing circuitry sensing a parameter of the patient, and a microprocessor coupled to the therapy component and the sensing circuitry to determine onset of a first state of the patient in response to the sensed physiologic parameter, and to determine whether the onset of the first state is detected for a predetermined time period.
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Citations
39 Claims
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1. An implantable medical device capable of being implanted in a patient, comprising:
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a therapy component configured to provide a therapy to the patient; sensing circuitry sensing a physiologic parameter corresponding to minute ventilation values indicative of a minute ventilation of the patient; and a microprocessor coupled to the therapy component and the sensing circuitry to detect onset of a first state of the patient in response to the sensed physiologic parameter, and to determine whether the onset of the first state is detected for a first predetermined time period, wherein the first state corresponds to an asleep state, and wherein the microprocessor receives a plurality of the minute ventilation values at predetermined time intervals over a period of time to generate a first distribution rate of minute ventilation values of the plurality of minute ventilation values received during first time intervals m of the predetermined time intervals, including a current time interval and first preceding time intervals m-1, and a second distribution rate of minute ventilation values received during second time intervals n of the predetermined time intervals, including the current time interval and second preceding time intervals n1, wherein the onset of the first state is detected in response to the second distribution rate being greater than the first distribution rate. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13)
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14. A method of providing therapy to a patient having an implantable medical device, comprising:
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sensing a physiologic parameter corresponding to minute ventilation values indicative of a minute ventilation of the patient; detecting onset of a first state of the patient in response to the sensed parameter, wherein the first state corresponds to an asleep state; and determining whether the onset of the first state is detected for a first predetermined time period, wherein detecting the onset of the first state comprises; determining a plurality of the minute ventilation values at predetermined time intervals over a period of time; generating a first distribution rate of minute ventilation values of the plurality of minute ventilation values received during first time intervals m of the predetermined time intervals, including a current time interval and first preceding time intervals m1, and a second distribution rate of minute ventilation values received during second time intervals n of the predetermined time intervals, including the current time interval and second preceding time intervals n1; and detecting the onset of the first state in response to the second distribution rate being greater than the first distribution rate. - View Dependent Claims (15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25)
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26. An implantable medical device capable of being implanted in a patient, comprising:
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means for sensing a physiologic parameter corresponding to minute ventilation values of a minute ventilation of the patient; means for detecting onset of a first state of the patient in response to the sensed parameter, wherein the first state corresponds to an asleep state; and means for determining whether the onset of the first state is detected for a first predetermined time period, wherein means for detecting the onset of the first state comprises; means for determining a plurality of the minute ventilation values at predetermined time intervals over a period of time; means for generating a first distribution rate of minute ventilation values of the plurality of minute ventilation values received during first time intervals m of the predetermined time intervals, including a current time interval and first preceding time intervals m1, and a second distribution rate of minute ventilation values received during second time intervals n of the predetermined time intervals, including the current time interval and second preceding time intervals n1; and means for detecting the onset of the first state in response to the second distribution rate being greater than the first distribution rate. - View Dependent Claims (27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37)
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38. A computer readable medium having computer executable instructions for performing a method comprising:
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sensing a physiologic parameter corresponding to minute ventilation values indicative of a minute ventilation of the patient; detecting onset of a first state of the patient in response to the sensed parameter, wherein the first state corresponds to an asleep state; and determining whether the onset of the first state is detected for a first predetermined time period, wherein detecting the onset of the first state comprises; determining a plurality of the minute ventilation values at predetermined time intervals over a period of time; generating a first distribution rate of minute ventilation values of the plurality of minute ventilation values received during first time intervals m of the predetermined time intervals, including a current time interval and first preceding time intervals m1, and a second distribution rate of minute ventilation values received during second time intervals n of the predetermined time intervals, including the current time interval and second preceding time intervals n1, and detecting the onset of the first state in response to the second distribution rate being greater than the first distribution rate.
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39. A computer readable medium having computer executable instructions for performing a method comprising:
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sensing minute ventilation values indicative of a minute ventilation of the patient; generating a first threshold and a second threshold corresponding to a physiologic transition of the patient between a first state and a second state in response to the minute ventilation values; generating a first distribution rate of a plurality of the sensed minute ventilation values received during first time intervals of predetermined time intervals including a first current time interval m and first preceding time intervals m 1 and a second distribution rate of a plurality of the sensed minute ventilation values received during second time intervals of the predetermined time intervals including a second time interval n and second preceding time intervals n1; detecting onset of the second state in response to the second distribution rate being less than the first threshold, an abrupt transition between the first state and the second state, and the second distribution rate being greater than or equal to the first distribution rate; and modifying the therapy in response to the detected onset of the second state.
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Specification