System and method utilizing guided fluorescence for high intensity applications

• US 7,208,007 B2
• Filed: 07/22/2004
• Issued: 04/24/2007
• Est. Priority Date: 08/07/2003
• Status: Expired due to Fees

• Current Assignee: Cutera Incorporated
• Original Assignee: Cutera Incorporated
• Inventors: Gollnick, David A., MacFarland, Dean A., Spooner, Gregory J., Nightingale, John L.
• Primary Examiner(s): Johnson, III; Henry M
• Application Number:
  US10/897,352
• Publication Number:
  US 20050063197A1
• Time in Patent Office: 1,006 Days
• Field of Search: 128/898, 607 88- 94, 362/551, 362/555, 606/9
• US Class Current: 607/90
• CPC Class Codes: A61B 18/203 applying laser energy to the outside of the body
• CPC Class Codes: A61B 2018/00452 Skin
• CPC Class Codes: G02B 6/0003 the light guides being doped with fluorescent agents
• CPC Class Codes: G02B 6/4298 coupling with non-coherent light sources and/or radiation detectors, e.g. lamps, incandescent bulbs, scintillation chambers

Abstract

A fluorescence concentrator system that provides for high brightness light source. The system can include a host doped with fluorescent material, which is optically pumped by an adjacent illumination source. The fluorescence concentrator captures a portion of the isotropically emitted fluorescent light and guides it to an output surface. The fluorescent energy emerging the output surface provides a high brightness light source suitable for a number of applications. For example, the fluorescence concentrator system can be used as the light source in a medical apparatus suitable for various aesthetic procedures. Further aspects of the fluorescent concentrator system can include providing for controlling the illumination source to output pumping energy suitable for high energy applications.

Claims

1. A fluorescence concentrator system including:

an illumination source;

a body which includes a fluorophore, and the body positioned to receive a pump energy from the illumination source, and wherein the fluorophore outputs fluorescent energy in response to the pump energy; and

wherein the body operates to guide at least a fraction of the fluorescent energy to an output surface of the body, the fraction of the fluorescence energy at the output surface is transmitted from the output surface as a therapeutic energy having an intensity of at least 10 W/cm².

2. The system of claim 1, further including:

a reflective structure surrounding at least a portion of the illumination source and a portion of the body.

3. The system of claim 1, wherein the illumination source includes a flashlamp.

4. The system according to claim 1, wherein said illumination source includes a plurality of light emitting diodes.

5. The system according to claim 1, wherein said illumination source includes a linear array of flat package light emitting diodes.

6. The system according to claim 1, wherein said illumination source includes a plurality of linear arrays of flat package light emitting diodes.

7. The system according to claim 1, further including:

a plurality of fibers configured to transmit the pump energy from the illumination source to the body.

8. The system according to claim 1, wherein the body includes a transparent host material doped with the fluorophore, and the body has an outer surface which is substantially optically smooth.

9. The system of claim 1, wherein said fluorophore is selected from the group consisting of organic dyes, inorganic ions, and quantum dots.

10. The system of claim 8, wherein said transparent host material is selected from the group consisting of polymers, glasses, crystals, and transparent ceramics.

11. The system of claim 1, further including:

an optical delivery module which receives the therapeutic energy from the output surface and transmits it to an area of tissue to be treated.

12. The system of claim 11, wherein the optical delivery module includes an optic fiber having a cross sectional area approximately equal to an area of the output surface of the body.

13. The system of claim 11, wherein the optical delivery module includes a filter through which the therapeutic energy is transmitted, and the filter operates to alter spectral characteristics of the therapeutic energy.

14. The system of claim 11, wherein the optical delivery module operates to modify a spectral characteristic of the therapeutic energy.

15. The system of claim 1, wherein the output surface has a first area, and wherein the body includes a second area which receives the pump energy, and the second area is greater than the first area.

16. The system of claim 15, wherein the first area is less than 1/10 (one-tenth) of a total surface area of the body.

17. The system of claim 1, wherein the body has a substantially cylindrical shape and the output surface is defined by a first end of the of the cylindrical shape.

18. The system of claim 1, wherein the body has a substantially cylindrical shape and a first end of the cylindrical shaped body is covered by a mirror, and the output surface of the body is defined by a second end of the cylindrical shape.

19. The system of claim 1, wherein the body has at least a first end which defines the output surface, and the body has a plurality of generally planar lateral sides for receiving optical energy from the illumination source, and wherein illumination source includes a plurality of discrete optical energy sources.

20. The system of claim 1, wherein the body has at least a first end which defines the output surface, and the body has a plurality of surface areas for receiving optical energy from the illumination source, and wherein illumination source includes a plurality of discrete optical energy sources.

21. The system of claim 1, wherein the body includes a core which has a first index of refraction and the body includes a cladding which surrounds the core, and the cladding has a second index of refraction, and wherein the first index of refraction is greater than the second index of refraction.

22. The system of claim 1, further including:

a cooled tip which has a first end which is coupled to the output surface of the body, and a second end which is placed in contact with an area to be treated, and wherein fluorescent energy is transmitted through the cooled tip to the area to be treated.

23. The system of claim 1, wherein the therapeutic energy has a greater spectral intensity than the spectral intensity of the illumination source.

24. The system of claim 1, wherein the therapeutic energy has a spectral intensity at least 50 times greater than the spectral intensity of the illumination source.

25. The system of claim 1, further including:

a housing in which the illumination source is secured adjacent to the body, such that pump energy is incident on the body; and

wherein a first portion of the body is positioned in the housing, and a second portion of the body, which includes the output surface, extends out of the housing.

26. A system for providing therapeutic treatments comprising:

an illumination source operative to output a pump energy;

a body positioned to receive the pump energy, and the body includes fluorophore which outputs fluorescent energy in response to the pump energy;

a controllable power supply coupled to the illumination source to provide electrical energy to drive the illumination source;

a processor coupled to the power supply;

an user interface coupled to the processor, which allows a user to input one or more operational parameters to the processor;

wherein in response to the user input the processor controls the power supply to provide electrical energy to drive the illumination source; and

wherein the body is shaped to guide at least a fraction of the fluorescent energy to an output surface of the body, and the fraction of the fluorescent energy is transmitted from the output surface as an application energy and wherein the spectral intensity of the application energy is greater than the spectral intensity of the illumination source.

27. The system of claim 26, wherein the application energy is of sufficient power to provide therapeutic treatment to an area of skin.

28. The system of claim 26, wherein the application energy has an intensity of at least 10 W/cm².

29. The system of claim 26, further including a cooling element coupled to the body, and the cooling element operates to cool at least the output surface of the body.

30. The system of claim 26, wherein the application energy is directed to an area of a patient'"'"'s skin to be treated;

and the system further including a cooling element which is applied to the area of the patient'"'"'s skin prior to directing the application energy to the area of the patient'"'"'s skin.

31. The system of claim 26, wherein the output surface is optically coupled with an area of a patient'"'"'s skin to be treated, such that the application energy is transmitted to the area of patient'"'"'s skin.

32. The system of claim 26, wherein a spectrum of the application energy matches the absorption spectrum of a chromophore found in an area of skin to be treated with the application energy.

33. The system of claim 26, wherein the system includes:

a housing having a mounting system which releasably secures the body in close proximity to the illumination;

the mounting system allowing a user to remove the body and replace it with a second body having a fluorophore.

34. A method of applying a treatment to an area of tissue, the method comprising:

applying a pump energy from an illumination source to a body which contains a fluorophore, and wherein the fluorophore generates fluorescent energy in response to the pump energy, and the body is shaped to concentrate at least a fraction of the fluorescent energy to an output surface of the body so that the spectral intensity of the fluorescent energy at the output surface of the body is greater than the spectral intensity of the illumination source; and

transmitting the fraction of the fluorescent energy through the output surface to an area of tissue being treated.

35. The method of claim 34, further including:

driving a flashlamp to apply the pump energy.

36. The method of claim 34, further including:

driving a plurality of LEDs to apply the pump energy.

37. The method of claim 34, further including:

receiving a user input for a desired treatment energy and determining an amount of pump energy to apply based on the desired treatment energy.

38. The method of claim 34, further including:

selecting a body having a fluorophore which outputs fluorescent energy having a spectral properties for a desired treatment.

39. The method of claim 34, further including:

placing the output surface in contact with the area of tissue.

40. The method of claim 39, further including the step of applying one of a liquid and a gel on the tissue being treated prior to placing the output surface of the body in contact with the tissue.

41. The method of claim 34, further including:

transmitting a fraction of the fluorescent energy from the output surface through a fiber prior to the fraction of fluorescent energy being incident on the area of tissue.

42. The method of claim 34, further including:

transmitting the fraction of the fluorescent energy from the output surface through a filter prior to the fraction of the fluorescent energy being incident on the area of tissue.

43. The method of claim 34, further including:

transmitting the fraction of the fluorescent energy from the output surface through a lens prior to the fraction of the fluorescent energy being incident on the area of tissue.

44. The method of claim 34, further including:

cooling the area of tissue to be treated.

45. The method of claim 34, further comprising:

providing a body which provides an output surface having at least one dimension which corresponds to a structure in the tissue which is targeted for treatment.

46. The method of claim 34, further comprising:

driving an illumination source to provide the pump energy, and wherein the pump energy is sufficient to cause the fluorescent energy at the output surface to correspond to an intensity of at least 10 W/cm².

47. The method of claim 34, further comprising:

driving an illumination source to output the pump energy with a pulse duration of less than 50 milliseconds.

48. The method of claim 34, further comprising:

placing the output surface proximal with the treatment area to provide a vascular treatment.

49. A device for providing fluorescent energy in response to a pulsed energy from a pulsed optical energy source, the device comprising:

a pulsed optical energy source;

a body which includes a transparent host doped with a fluorophore, the fluorophore generating fluorescent energy in response to the pulsed energy;

the body having an input surface area where the pulsed energy is transmitted into the body, and the input surface area has a first length which corresponds to a length of the pulsed optical energy source; and

the body having a shape which operates to guide at least part of the fluorescent energy to an output surface.

50. The device of claim 49, wherein the first length corresponds to the length of a flashlamp.

51. The device of claim 49, wherein the first length corresponds to the length of an array of LEDs.

52. The device of claim 49, wherein the body includes:

a core which has a first index of refraction and the body includes a cladding which surrounds the core, and the cladding has a second index of refraction, and wherein the first index of refraction is greater than the second index of refraction.

53. The device of claim 49, wherein the body is configured to concentrate the fluorescent energy into the output surface so that the spectral intensity of the fluorescent energy at the output surface is greater that the spectral intensity of the optical energy source.

54. A fluorescence concentrator system including:

an illumination source generating pump energy;

a body;

a plurality of fibers configured to transmit the pump energy from the illumination source to the body, wherein said body includes a fluorophore which outputs fluorescent energy in response to the pump energy and wherein the body operates to guide at least a fraction of the fluorescent energy to an output surface of the body, and the fraction of the fluorescent energy at the output surface is transmitted from the output surface as a therapeutic energy and wherein the therapeutic energy has a greater spectral intensity than the spectral intensity of the illumination source.

55. A fluorescence concentrator system including:

an illumination source;

a body which includes a fluorophore, the body positioned to receive a pump energy from the illumination source, and wherein the fluorophore outputs fluorescent energy in response to the pump energy wherein the body operates to guide at least a fraction of the fluorescent energy to an output surface of the body; and

an optical delivery module which receives the therapeutic energy from the output surface of the body and transmits the energy to an area of tissue to be treated as a therapeutic energy and wherein the therapeutic energy has a greater spectral intensity than the spectral intensity of the illumination source.

56. A fluorescence concentrator system including:

an illumination source;

a body which includes a fluorophore, the body having a substantially cylindrical shape with a first end of the cylindrical shaped body being covered by a mirror, and with the second end of the cylindrical shape defining an output surface, the body being positioned to receive a pump energy from the illumination source, and wherein the fluorophore outputs fluorescent energy in response to the pump energy, and

wherein the body operates to guide at least a fraction of the fluorescent energy to the output surface of the body, and the fraction of the fluorescent energy at the output surface is transmitted from the output surface as a therapeutic energy and wherein the therapeutic energy has a greater spectral intensity than the spectral intensity of the illumination source.

57. A fluorescence concentrator system including:

an illumination source;

a body which includes a fluorophore, wherein the body includes a core which has a first index of refraction and the body includes a cladding which surrounds the core, and the cladding has a second index of refraction, and wherein the first index of refraction is greater than the second index of refraction and wherein the body is positioned to receive a pump energy from the illumination source, and wherein the fluorophore outputs fluorescent energy in response to the pump energy; and

wherein the body operates to guide at least a fraction of the fluorescent energy to an output surface of the body, and the fraction of the fluorescent energy at the output surface is transmitted from the output surface as a therapeutic energy and wherein the therapeutic energy has a greater spectral intensity than the spectral intensity of the illumination source.

58. A method of applying a treatment to an area of tissue, the method comprising:

receiving a user input for a desired treatment energy and determining an amount of pump energy to apply based on the desired treatment energy;

applying a pump energy to a body which contains a fluorophore, and wherein the fluorophore generates fluorescence energy in response to the pump energy, and the body is shaped to guide at least a fraction of the fluorescent energy to an output surface of the body; and

transmitting the fraction of the fluorescent energy through the output surface to an area of tissue being treated.

59. The method of claim 58, wherein the body functions to concentrate the fluorescent energy so that the spectral intensity of the fluorescent energy at the output surface of the body is greater than the spectral intensity of the pump energy.

60. The method of claim 59, further including the step of placing the output surface in contact with the area of tissue.

61. The method of claim 60, further including the step of applying one of a liquid and a gel on the tissue being treated prior to placing the output surface of the body in contact with the tissue.

62. A method of applying a treatment to an area of tissue, the method comprising:

applying a pump energy to a body which contains a fluorophore, and wherein the fluorophore generates fluorescent energy in response to the pump energy, and the body is shaped to guide at least a fraction of the fluorescent energy to an output surface of the body; and

delivering the fraction of the fluorescent energy from the output surface of the body via a fiber to an area of tissue being treated.

63. The method of claim 62, wherein the pump energy is supplied by an illumination source and wherein the body functions to concentrate the fluorescent energy so that the spectral intensity of the fluorescent energy at the output surface of the body is greater than the spectral intensity of the pump energy.

64. A method of applying a treatment to an area of tissue, the method comprising:

applying a pump energy to a body which contains a fluorophore, and wherein the fluorophore generates fluorescent energy in response to the pump energy, and the body is shaped to guide at least a fraction of the fluorescent energy to an output surface of the body;

transmitting the fraction of the fluorescent energy from the output surface of the body through a filter; and

delivering the filtered transmitted fluorescent energy to an area of tissue being treated.

65. The method of claim 64, wherein the pump energy is supplied by an illumination source and wherein the body functions to concentrate the fluorescent energy so that the spectral intensity of the fluorescent energy at the output surface of the body is greater than the spectral intensity of the pump energy.

66. A method of applying a treatment to an area of tissue, the method comprising:

applying a pump energy to a body which contains a fluorophore, and wherein the fluorophore generates fluorescent energy in response to the pump energy, and the body is shaped to guide at least a fraction of the fluorescent energy to an output surface of the body;

transmitting the fraction of the fluorescent energy through the output surface to an area of tissue being treated; and

cooling the area of tissue which is treated with the fluorescent energy wherein the pump energy is supplied by an illumination source and wherein the body functions to concentrate the fluorescent energy so that the spectral intensity of the fluorescent energy at the output surface of the body is greater than the spectral intensity of the source.

67. A method as recited in claim 66, wherein said cooling step is performed before the fluorescent energy is applied to the tissue.

68. A method as recited in claim 66, wherein said cooling step is performed while the fluorescent energy is being applied to the tissue.

69. A method as recited in claim 66, wherein said cooling step is performed both prior to and while the fluorescent energy is being applied to the tissue.

70. The method of claim 66, further including the step of placing the output surface in contact with the area of tissue.

71. The method of claim 70, further including the step of applying one of a liquid and a gel on the tissue being treated prior to placing the output surface of the body in contact with the tissue.

72. A method of applying a treatment to an area of tissue, the method comprising:

applying a pump energy to a body which contains a fluorophore, and wherein the fluorophore generates fluorescence energy in response to the pump energy, and the body is shaped to guide at least a fraction of the fluorescent energy to an output surface of the body;

transmitting the fraction of the fluorescent energy through the output surface to an area of tissue being treated; and

driving an illumination source to provide the pump energy, and wherein the pump energy is sufficient to cause the fluorescent energy at the output surface of the body to correspond to an intensity of at least 10 W/cm².

73. The method of claim 72, wherein the body functions to concentrate the fluorescent energy so that the spectral intensity of the fluorescent energy at the output surface of the body is greater than the spectral intensity of the source.

74. The method of claim 73, further including the step of placing the output surface in contact with the area of tissue.

75. The method of claim 74, further including the step of applying one of a liquid and a gel on the tissue being treated prior to placing the output surface of the body in contact with the tissue.

76. A method of applying a treatment to an area of tissue, the method comprising:

generating pulsed pump energy from an illumination source, said pulses having a duration less than 50 milliseconds;

applying the pump energy to a body which contains a fluorophore, and wherein the fluorophore generates fluorescent energy in response to the pump energy, and the body is shaped to guide at least a fraction of the fluorescent energy to an output surface of the body; and

transmitting the fraction of the fluorescent energy through the output surface to an area of tissue being treated wherein the body functions to concentrate the fluorescent energy so that the spectral intensity of the fluorescent energy at the output surface of the body is greater than the spectral intensity of the source.

77. The method of claim 76, further including the step of placing the output surface in contact with the area of tissue.

78. The method of claim 77, further including the step of applying one of a liquid and a gel on the tissue being treated prior to placing the output surface of the body in contact with the tissue.