Metallic composite coating for delivery of therapeutic agents from the surface of implantable devices

• US 7,208,172 B2
• Filed: 11/03/2003
• Issued: 04/24/2007
• Est. Priority Date: 11/03/2003
• Status: Expired due to Fees

• Current Assignee: Medlogics Device Corporation
• Original Assignee: Medlogics Device Corporation
• Inventors: Birdsall, Matthew J., Klein, Richard L., Maier, Nathan
• Primary Examiner(s): Azpuru; Carlos A.
• Application Number:
  US10/701,262
• Publication Number:
  US 20050092615A1
• Time in Patent Office: 1,268 Days
• Field of Search: 424/423
• US Class Current: 424/423
• CPC Class Codes: A61L 2300/102 Metals or metal compounds, e.g. salts such as bicarbonates, carbonates, oxides, zeolites, silicates
• CPC Class Codes: A61L 2300/104 Silver, e.g. silver sulfadiazine
• CPC Class Codes: A61L 2300/41 Anti-inflammatory agents, e.g. NSAIDs
• CPC Class Codes: A61L 2300/414 Growth factors
• CPC Class Codes: A61L 2300/416 Anti-neoplastic or anti-proliferative or anti-restenosis or anti-angiogenic agents, e.g. paclitaxel, sirolimus
• CPC Class Codes: A61L 2300/42 Anti-thrombotic agents, anticoagulants, anti-platelet agents
• CPC Class Codes: A61L 2300/608 having two or more layers
• CPC Class Codes: A61L 31/088 Other specific inorganic materials not covered by A61L31/084 or A61L31/086
• CPC Class Codes: A61L 31/16 Biologically active materials, e.g. therapeutic substances A61L31/047 takes precedence

Abstract

A metallic composite coating, and methods for forming same, for an implantable medical device is disclosed. The composite coating comprises at least one metal or metallic tie layer formed on the surface of the device, followed by an electroless electrochemical cladding of one or more additional layers over the tie layer. One or more therapeutic or biologically active agents are co-deposited with at least one of the electroless electrochemical claddings.

Claims

1. A medical device comprising:

a substrate having an outer surface; and

a composite coating on said outer surface including a plurality of layers which are comprised of;

a first metal layer; and

a second metallic composite layer comprising a metal and at least one therapeutic material wherein said therapeutic material is selected from the group consisting of rapamycin (sirolimus), rapamycin (sirolimus) analogs, paclitaxel, paclitaxel derivatives, growth factors, heparin, aspirin, tetracycline, dexamethasone, des-aspartate angiotensin I, tachykinins, sialokinins, apocynin, siRNA, pleiotrophin, exochelins, and combinations thereof.

2. The medical device according to claim 1 wherein the first metal layer is electroplated on the outer surface of the substrate.

3. The medical device according to claim 1 wherein the metal comprising said first metal layer is selected from the group of metals consisting of nickel, cobalt, copper, gold, silver, platinum, chromium, palladium, and molybdenum.

4. The medical device according to claim 1 wherein the substrate is a metal or a metal alloy.

5. The medical device according to claim 4 wherein the substrate is a metal alloy selected from the group consisting of stainless steel, cobalt-chromium, nickel-titanium, platinum-iridium, and niobium-zirconium.

6. The medical device according to claim 1 wherein the substrate is a stent.

7. The medical device according to claim 1 wherein the at least one therapeutic material in said second metallic composite layer comprising a substance which is more radiopaque relative to the substrate.

8. The medical device according to claim 1 further comprising a top layer over the second metallic composite layer.

9. The medical device according to claim 8 wherein said top layer is a metallic layer.

10. The medical device according to claim 9 wherein said top layer is a polymeric material.