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Sensor surfaces for detecting analytes

  • US 7,208,322 B2
  • Filed: 04/02/2002
  • Issued: 04/24/2007
  • Est. Priority Date: 04/02/2001
  • Status: Expired due to Fees
First Claim
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1. A sensor surface for detecting the interaction of a biological binding pair, said sensor surface comprising:

  • a substrate coated with a free electron metal;

    a matrix layer disposed on said free electron metal, said matrix layer comprising an organic compound, wherein said organic compound has a boronic acid complexing moiety;

    a boronic acid moiety complexed to said boronic acid complexing moiety; and

    a first member of said binding pair conjugated to said boronic acid moiety, wherein said first member binds to a second member of said binding pair such that a detectable response is elicited.

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