CT colonography system

• US 7,209,536 B2
• Filed: 11/19/2004
• Issued: 04/24/2007
• Est. Priority Date: 11/19/2004
• Status: Active Grant

• Current Assignee: General Electric Company
• Original Assignee: General Electric Company
• Inventors: Walter, Deborah, Piacsek, Kelly L.
• Primary Examiner(s): Thomas; Courtney
• Assistant Examiner(s): TANINGCO, ALEXANDER H
• Application Number:
  US10/904,630
• Publication Number:
  US 20060109953A1
• Time in Patent Office: 886 Days
• Field of Search: 378/5, 378/49, 378/82, 378/83, 378/56, 378 6- 10, 378 15- 20, 378/48, 600/420, 600/431
• US Class Current: 378/5
• CPC Class Codes: A61B 6/032 Transmission computed tomography [CT]
• CPC Class Codes: A61B 6/4035 the source being combined with a filter or grating
• CPC Class Codes: A61B 6/4042 K-edge filters
• CPC Class Codes: A61B 6/405 Source units specially adapted to modify characteristics of the beam during the data acquisition process A61B6/4021, A61B6/4035 take precedence
• CPC Class Codes: A61B 6/4241 using energy resolving detectors, e.g. photon counting
• CPC Class Codes: A61B 6/482 involving multiple energy imaging

Abstract

A method and system of CT colonography is presented that includes the acquisition of energy sensitive or energy-discriminating CT data from a colorectal region of a subject. CT data is acquired and decomposed into basis material density maps and used to differentiate and enhance contrast between tissues in the colorectal region. The invention is particularly applicable with the detection of colon polyps without cathartic preparation or insufflation of the colorectal region. The invention is further directed to the automatic detection of colon polyps.

Claims

1. An imaging scanner comprising:

a radiation source;

a radiation detector; and

a computer programmed to decompose CT data acquired by the radiation detector into a first dataset and a second dataset to delineate composition of a colorectal region of a subject, the colorectal region having an intravenously administered contrast agent positioned in a polyp attached to a colon wall, wherein the first dataset is comprised of data at an energy level different than that of the second dataset.

2. The imaging scanner of claim 1 wherein the computer is further programmed to reconstruct an image of the colorectal region of the subject with contrast between stool and polyps.

3. The imaging scanner of claim 2 wherein the computer is further programmed to display the image with color-coded differentiation between the stool and the polyps.

4. The imaging scanner of claim 1 wherein the computer is further programmed to decompose the CT data such that the first dataset is comprised of data corresponding to water and the second dataset is comprised of data corresponding to contrast agent.

5. The imaging scanner of claim 1 wherein the computer is further programmed to automatically determine presence of colon polyps in the colorectal region of the subject from the decomposed CT data.

6. The imaging scanner of claim 5 wherein the computer is further programmed to compare a material basis density pair to a look-up table and, from the comparison, determine if that imaged corresponds to a colon polyp.

7. The imaging scanner of claim 6 wherein the computer is further programmed to image the colorectal region of the subject with colon polyp detection without cathartic preparation or insufflation of the colorectal region of the subject.

8. A method of CT imaging comprising the steps of:

acquiring energy sensitive CT data from an ROI of a subject;

decomposing the energy sensitive CT data into a first energy bin and a second energy bin, wherein the first energy bin is segmented to represent a density of a contrast agent intravenously administered and the second energy bin is segmented to represent a density of water; and

encoding pixels corresponding to data from the first energy bin dissimilarly than pixels corresponding to data from the second energy bin to enhance contrast in an image of the ROI.

9. The method of claim 8 wherein the ROI includes a colorectal region of the subject and further comprising the step of introducing a contrast agent into the ROI.

10. The method of claim 8 further comprising the step of imaging the ROI without cathartic preparation or insufflation of the ROI.

11. The method of claim 8 further comprising the step of decomposing the energy sensitive CT data into a first energy bin comprised of data corresponding to water and a second energy bin comprised of data corresponding to contrast agent.

12. The method of claim 11 further comprising the step of reconstructing an image of the ROI with color-coded differentiation between data of differentiated materials.

13. The method of claim 8 further comprising the step of reconstructing a single image comprised of data from a CT image and two-dimensional basis material data.

14. A computer readable storage medium having a computer program stored thereon and representing a set of instructions that when executed by a computer causes the computer to:

receive energy sensitive CT data acquired from a colorectal region of a subject;

decompose the energy sensitive CT data into at least two datasets;

assign an encoding value to each dataset; and

reconstruct an image of the colorectal region with contrast between stool and abnormal tissue of the colorectal region without insufflation of the colorectal region, the abnormal tissue having a first contrast agent therein, and the stool having a second contrast agent therein.

15. The computer readable storage medium of claim 14 wherein the computer is further caused to color-code the image to enhance contrast between materials of the colorectal region.

16. The computer readable storage medium of claim 14 wherein the computer is further caused to automatically determine colon polyps in the colorectal region.

17. The computer readable storage medium of claim 16 wherein the computer is further caused to compare material basis data from the energy sensitive CT data to a threshold and, based on the comparison, determine colon polyp presence in the colorectal region.

18. The computer readable storage medium of claim 14 wherein the computer is further programmed to decompose the energy sensitive CT data into datasets representing two basis materials.

19. The computer readable storage medium of claim 18 wherein the contrast agent dataset includes data acquired from a intravenous or orally administered contrast agent into the colorectal region of the subject.

20. A CT system comprising:

a radiation source;

a radiation detector; and

a computer programmed to;

receive data in a first energy spectrum acquired from a colorectal region of a subject, the colorectal region comprising stool, polyps, and a colon wall wherein iodine is an intravenously administered contrast agent in one of the polyps and the colon wall;

receive data in a second energy spectrum acquired from the colorectal region of the subject; and

reconstruct an image of the colorectal region of the subject with contrast between data in the first energy spectrum and data in the second energy spectrum.

21. A CT system comprising:

a radiation source;

a radiation detector; and

a computer programmed to;

receive data in a first energy spectrum acquired from a colorectal region of a subject;

receive data in a second energy spectrum acquired from the colorectal region of the subject; and

detect a labeled, intravenously administered contrast agent delivered to an abnormal tissue of the colorectal region from the received data.

22. A CT system comprising:

a radiation source;

a radiation detector; and

a computer programmed to;

receive data regarding a first energy spectrum acquired from a colorectal region of a subject;

receive data regarding a second energy spectrum acquired from the colorectal region of the subject; and

automatically characterize tissue as cancerous and non-cancerous based upon the received data.

23. A method of CT imaging comprising the steps of:

acquiring energy sensitive CT data from an ROI of a subject, wherein the ROI includes a colorectal region of the subject;

introducing a contrast agent into the ROI;

decomposing the energy sensitive CT data into a first energy bin and a second energy bin; and

encoding pixels corresponding to data from the first energy bin dissimilarly than pixels corresponding to data from the second energy bin to enhance contrast in an image of the ROI.

24. A method of CT imaging comprising the steps of:

acquiring energy sensitive CT data from an ROI of a subject;

imaging the ROI without cathartic preparation or insufflation of the ROI;

decomposing the energy sensitive CT data into a first energy bin and a second energy bin; and

encoding pixels corresponding to data from the first energy bin dissimilarly than pixels corresponding to data from the second energy bin to enhance contrast in an image of the ROI.