System and method providing directional ultrasound therapy to skeletal joints

• US 7,211,055 B2
• Filed: 01/15/2003
• Issued: 05/01/2007
• Est. Priority Date: 01/15/2002
• Status: Expired due to Term

• Current Assignee: Regents of the University of California (University of California)
• Original Assignee: Regents of the University of California (University of California)
• Inventors: Bradford, David S., Lotz, Jeffrey C., Nau, Will, Diederich, Chris J.
• Primary Examiner(s): Peffley; Michael
• Assistant Examiner(s): ROANE, AARON F
• Application Number:
  US10/347,164
• Publication Number:
  US 20030216721A1
• Time in Patent Office: 1,567 Days
• Field of Search: 601/2, 606/41, 606/49, 607/108, 607/109, 607115-117, 607/105
• US Class Current: 601/2
• CPC Class Codes: A61B 18/04 by heating by applying electromagnetic radiation A61B18/18; hyperthermia using electric or magnetic fields, radiation or ultrasound A61N
• CPC Class Codes: A61B 2017/00092 using thermocouples
• CPC Class Codes: A61B 2017/00101 using an array of thermosensors
• CPC Class Codes: A61B 2017/00261 Discectomy
• CPC Class Codes: A61B 2090/374 NMR or MRI
• CPC Class Codes: A61N 2007/0021 Neural system treatment
• CPC Class Codes: A61N 2007/003 Destruction of nerve tissue
• CPC Class Codes: A61N 2007/0056 Beam shaping elements
• CPC Class Codes: A61N 2007/0078 with multiple treatment transducers
• CPC Class Codes: A61N 7/02 Localised ultrasound hyperthermia hyperthermia in general A61F7/00
• CPC Class Codes: A61N 7/022 intracavitary

Abstract

An ultrasound therapy system and method is provided that provides directional, focused ultrasound to localized regions of tissue within body joints, such as spinal joints. An ultrasound emitter or transducer is delivered to a location within the body associated with the joint and heats the target region of tissue associated with the joint from the location. Such locations for ultrasound transducer placement may include for example in or around the intervertebral discs, or the bony structures such as vertebral bodies or posterior vertebral elements such as facet joints. Various modes of operation provide for selective, controlled heating at different temperature ranges to provide different intended results in the target tissue, which ranges are significantly effected by pre-stressed tissues such as in-vivo intervertebral discs. In particular, treatments above 70 degrees C., and in particular 75 degrees C., are used for structural remodeling, whereas lower temperatures achieves other responses without appreciable remodeling.

Claims

1. A method for invasively treating a medical condition associated with a spinal joint within a body of a patient, comprising:

positioning a directional ultrasound transducer at a location within the body of the patient and externally adjacent to a structure associated with the spinal joint; and

using the directional ultrasound transducer at the location externally adjacent to the structure, directionally delivering a therapeutic level of ultrasound energy in a first direction into a region of tissue associated with the structure of the joint from the location and without delivering a substantial level of ultrasound energy in a second direction opposite the first direction.

7. The method of claim 1, 2, 3, 4, 5, or 6, further comprising:

focusing the ultrasound energy from the directional ultrasound transducer toward the region of tissue in the first direction from the location.

8. The method of claim 1, 2, 4, or 5, wherein the region of tissue comprises at least a portion of an intervertebral disc.

9. The method of claim 8, wherein the region of tissue comprises at least a portion of an annulus fibrosus of the intervertebral disc.

10. The method of claim 1, 2, 3, 4, 5, or 6, wherein the location is adjacent to and outside of an annulus fibrosus of an intervertebral disc being heated.

11. The method of claim 1, 2, 4, or 5, wherein the location is adjacent to a vertebral body associated with the spinal joint, and the region of tissue comprises a portion of the vertebral body.

12. The method of claim 1, 2, 4, 5, or 6, wherein the region comprises a portion of at least one of an intervertebral disc and a bony structure associated with the spinal joint.

13. The method of claim 1, 2, 3, 4, 5, or 6, further comprising:

actively cooling a location associated with the ultrasound transducer and otherwise heated by the ultrasound transducer.

14. The method of claim 13, wherein the active cooling comprises actively cooling the ultrasound transducer.

15. The method of claim 1, 2, 3, 4, 5, or 6, wherein the structure comprises an intervertebral disc.

16. The method of claim 1, 2, 3, 4, 5, or 6, wherein the structure comprises a bony structure.

17. The method of claim 16, wherein the bony structure comprises a vertebral body.

2. A method for treating a medical condition associated with a spinal joint within a body of a patient, comprising:

positioning a directional ultrasound transducer at a location within the body of the patient and externally adjacent to a structure associated with the spinal joint; and

using the directional ultrasound transducer at the location, directionally delivering a sufficient level of ultrasound energy in a first direction into a region of tissue associated with the structure of the spinal joint that is sufficient to necrose nociceptive nerve fibers or inflammatory cells in such tissue region without substantially affecting collagenous structures associated with the structure, and without delivering a substantial level of ultrasound energy in a second direction opposite the first direction.

3. A method for treating a region of tissue associated with an intervertebral disc in a body of a patient, comprising:

positioning a directional ultrasound transducer to a location within the body externally adjacent to the intervertebral disc such that a therapeutic level of ultrasound energy may be directionally coupled from the transducer in a first direction into the region tissue from outside of the intervertebral disc, and such that ultrasound energy will not be delivered in a second direction opposite the first direction.

4. A method for treating a patient, comprising:

positioning a directional ultrasound transducer at a location within the patient'"'"'s body;

delivering directional ultrasound energy in a first direction from a directional ultrasound transducer at a location externally adjacent to a structure associated with a spinal joint and such that the directional ultrasound energy is directed from the location into a region of tissue associated with the structure and without delivering substantial energy in a second direction that is opposite the first direction; and

controlling the directional ultrasound energy delivery such that the tissue receiving the directional ultrasound energy does not experience a rise in temperature of to more than about 55 degrees C.

5. A method for treating a patient, comprising:

directionally delivering energy from a directional ultrasound transducer positioned at a location externally adjacent to a structure associated with a spinal joint and at a location within the patient'"'"'s body, such that the energy is directed in a first direction into a region of tissue associated with the structure and without delivering a substantial level of energy in a second direction opposite the first direction;

wherein such directional energy delivery is at a thermal dose within a range that is between about 10 and about 300 equivalent minutes at about 43 degrees C.; and

wherein such directional energy delivered in a manner that does not substantially remodel collagen in the structure.

6. A method for invasively treating a medical condition associated with an intervertebral disc within a body of a patient, comprising:

directionally delivering a therapeutic level of ultrasound energy in a first direction into a region of tissue associated with an intervertebral disc from a directional ultrasound transducer positioned at a location within the body of the patient and externally adjacent to the intervertebral disc and without delivering a substantial level of ultrasound energy from the directional ultrasound transducer in a second direction that is opposite the first direction.