Biocompatible bonding method and electronics package suitable for implantation

• US 7,211,103 B2
• Filed: 06/17/2002
• Issued: 05/01/2007
• Est. Priority Date: 04/11/2002
• Status: Active Grant

• Current Assignee: Cortigent Incorporated
• Original Assignee: Second Sight Medical Products, Inc.
• Inventors: Greenberg, Robert J., Mann, Alfred E., Talbot, Neil, Ok, Jerry
• Primary Examiner(s): Getzow; Scott M.
• Application Number:
  US10/174,349
• Publication Number:
  US 20030233133A1
• Time in Patent Office: 1,779 Days
• Field of Search: 607 1- 28
• US Class Current: 607/1
• CPC Class Codes: A61N 1/0543 Retinal electrodes
• CPC Class Codes: A61N 1/36046 of the eye
• CPC Class Codes: A61N 1/375 Constructional arrangements, e.g. casings
• CPC Class Codes: A61N 1/3758 Packaging of the components within the casing
• CPC Class Codes: H05K 1/0306 Inorganic insulating substrates, e.g. ceramic, glass
• CPC Class Codes: H05K 2201/09127 PCB or component having an integral separable or breakable part
• CPC Class Codes: H05K 2201/1028 Thin metal strips as connectors or conductors
• CPC Class Codes: H05K 2201/10287 Metal wires as connectors or conductors
• CPC Class Codes: H05K 2201/10295 Metallic connector elements partly mounted in a hole of the PCB
• CPC Class Codes: H05K 2201/10977 Encapsulated connections applying non-metallic protective coatings for encapsulating mounted components H05K3/284
• CPC Class Codes: H05K 2203/0733 Method for plating stud vias, i.e. massive vias formed by plating the bottom of a hole without plating on the walls
• CPC Class Codes: H05K 2203/1446 Treatment after insertion of lead into hole, e.g. bending, cutting, caulking or curing of adhesive but excluding soldering
• CPC Class Codes: H05K 3/321 by conductive adhesives
• CPC Class Codes: H05K 3/328 by welding
• CPC Class Codes: H05K 3/361 Assembling flexible printed circuits with other printed circuits
• CPC Class Codes: H05K 3/4015 using auxiliary conductive elements, e.g. pieces of metal foil, metallic spheres
• CPC Class Codes: H05K 3/423 characterised by electroplating method
• CPC Class Codes: H05K 3/4652 Adding a circuit layer by laminating a metal foil or a preformed metal foil pattern H05K3/4647 takes precedence
• CPC Class Codes: H05K 3/4691 Rigid-flexible multilayer circuits comprising rigid and flexible layers, e.g. having in the bending regions only flexible layers
• CPC Class Codes: Y10T 29/49155 Manufacturing circuit on or in base

Abstract

The invention is directed to a method of bonding a hermetically sealed electronics package to an electrode or a flexible circuit and the resulting electronics package, that is suitable for implantation in living tissue, such as for a retinal or cortical electrode array to enable restoration of sight to certain non-sighted individuals. The hermetically sealed electronics package is directly bonded to the flex circuit or electrode by one of several methods, including attachment by an electrically conductive adhesive, such as epoxy or polyimide, containing platinum metal flake in biocompatible glue; diffusion bonding of platinum bumps covered by an insulating layer; thermal welding of wire staples; or an integrated interconnect fabrication. The resulting electronic device is biocompatible and is suitable for long-term implantation in living tissue.

Claims

1. An implantable device comprising:

a substrate containing electrically conductive feedthroughs forming electrically conductive pads on a first side of said substrate;

a first flexible electrically insulating layer on said first side of said substrate;

said first flexible electrically insulating layer defining voids adjacent to said conductive pads;

a flexible electrically conducting layer on. said first flexible electrically insulating layer wherein at least a portion of said flexible electrically conducting layer physically contacts said conductive pads; and

a second flexible electrically insulating layer on said flexible electrically conductive layer.

2. The implantable device according to claim 1, wherein said substrate is a rigid substrate.

3. The implantable device according to claim 1, wherein a portion of said substrate is removed.

4. The implantable device according to claim 1, wherein at least one of said first electrically insulating layer or said second flexible electrically insulating layer defines additional voids remote to said substrate.

5. The implantable device according to claim 1, further comprising an electrical circuit on said substrate.

6. The implantable device according to claim 5, further comprising a hermetic package enclosing said electrical circuit.

7. The iinplantable device according to claim 1, wherein the substrate comprises an integrated circuit.

8. The implantable device according to claim 7, where said itnegrated circuit is within a hermetic package.

9. The implantable device according to claim 7, where said substrate a hybrid circuit.

10. The impiantable device according to claim 1, wherein any of said voids are formed by laser cutting.

11. The implantable device according to claim 1, wherein any of said voids are formed by plasma etching.

12. The implantable device according to claim 1, wherein any of said layers are formed by ion-beam assisted deposition.

13. The implantable device according to claim 1, wherein said implantable device is a neural interface.

14. A method of making an implantable device comprising:

providing a substrate containing electrically conductive feedthroughs forming electrically conductive pads on a first side of said substrate;

depositing a first flexible electrically insulating Layer on said first side of said substrate;

defining voids in said first flexible electrically insulating layer adjacent to said conductive pads;

depositing a flexible electrically conducting layer on said first flexible electrically insulating layer where at least a portion of said flexible electrically conducting layer and physically contacts said conductive pads; and

depositing a second flexible electrically insulating layer on said flexible electrically conductive layer.

15. The method according to claim 14, further comprising the step of releasing at least a portion of said first flexible insulating layer from said substrate.

16. The method according to claim 14, where in said biocompatible metal is comprised of platinum flake.

17. The method according to claim 14, wherein said substrate is a rigid substrate.

18. The method according to claim 14, further comprising the step of cutting away a portion of said substrate.

19. The method according to claim 14, further comprising the step of creating additional voids remote to said substrate in a layer selected from the group consisting of said first electrically insulating layer and said second flexible electrically insulating layer.

20. The method according to claim 14, further comprising the step of forming an electrical circuit on said substrate.

21. The method according to claim 14, further comprising the step of forming a hermetic package enclosing said electrical circuit.

22. The method according to claim 14, wherein the substrate comprises an integrated circuit.

23. The method according to claim 14, wherein any of said voids steps are accomplished by laser cutting.

24. The method according to claim 14, wherein said step of creating voids in said first flexible electrically insulating layer is accomplished by plasma etching.

25. The method according to claim 14, wherein any of said depositing steps are accomplished by ion-beam assisted deposition.

26. An implantable electronic device comprising:

a hermetic electronics control unit,

a first thin film flexible electrically insulating substrate;

an electrically conducting metal layer deposited on said first insulating layer;

a second thin film flexible electrically insulating substrate deposited on said electrically conducting metal layer;

at least one of said first flexible electrically insulating substrate or said second flexible electrically insulating substrate defining holes that expose said electrically conducting metal layer forming contacts and means for bonding said electronics'"'"'control unit to said implantable electronic device.

27. The implantable electronic device according to claim 26, wherein said hermetic electronics control unit is an integrated circuit.

28. The implantable electronic device according to claim 26, wherein said hermetic electronics control unit is a hybrid circuit.

29. The implantable electronic device according to claim 26, wherein said means for bonding said electronics control unit to said implantable electronic device is an electrically conductive adhesive.

30. The implantable electronic device according to claim 29, wherein said electrically conductive adhesive is comprised of platinum metal flake.

31. The implantable electronic device according to claim 29, wherein said electrically conductive adhesive is comprised of epoxy or polyimide containing electrically conductive particulate of a biocompatible metal.

32. The implantable electronic device according to claim 31, wherein said biocoinpatible metal is comprised of platinum, iridium, titanium, platinum alloys, iridium alloys, or titanium alloys.

33. The implantable electronic device according to claim 29, wherein said electrically conductive adhesive is comprised of silicone.

34. The implantable electronic device according to claim 26, wherein said means for bonding said electronics control unit to said implantable electronic device is an electrically conductive studbump.

35. The implantable electronic device according to claim 26, wherein said stud bump is comprised of platinum or a platinum alloy.

36. The implantable electronic device according to claim 26, wherein said means for bonding said electronics control unit to said implantable electronic device is a staple.

37. The implantable electronic device according to claim 36, wherein said staple is comprised of platinum or a platinum alloy.

38. The implantable electronic device according to claim 26, wherein said means for bonding said electronics control unit to said implantable electronic device is a tail-ball.

39. The implantable electronic device according to claim 26, wherein said tail-bail is comprised of platinum or a platinum alloy.

40. A method of bonding an iinplantable electronics control unit to a thin film flexible circuit for implantation as a neural interface, said method comprising the steps of:

applying electrically conductive adhesive to input/output contacts of a hybrid substrate,

applying electrically conductive adhesive to bond pads of a flexible electrically insulating substrate,

placing said input/output contacts in alignment with said bond pads, and

curing said conductive adhesive.

41. A method of bonding two implantable devices comprising the steps of:

studbumping bond pads of a first device with biocompatible materials;

studbumping bond pads of a second device with biocompatible materials;

placing said bond pods in alignment; and

bonding said studbumps together by a thermomechanical process.

42. The method according to claim 41, wherein said devices are hermetically sealed electronics packages further comprising at least one electrode.

43. The method according to claim 41, wherein said bond pads are further comprised of platinum.

44. The method according to claim 41, wherein said biocompatible materials are comprised of platinum.

45. A method of bonding two implantable devices comprising the steps of:

studbumping bond pads on a first device with gold studbumps;

studbumping bond pads on a second device with gold studbumps;

placing said bond pads in alignment;

bonding said studbumps together by a thermomechanical process; and

underfilling space between said first device and said second device with a water resistant insulating material.

46. The method according to claim 45, further comprising the step of plating a least one of said bond pads prior to studbumping.

47. A method of bonding two implantable devices, said method comprising the steps of:

locating a bond pad of a first substrate;

modifying said bond pad forming a through hole at the center of said bond pad;

aligning said through bole of flexible electrically insulating substrate with an input/output contact of a second substrate;

placing wire across said through bole in said bond pad of said first substrate;

bonding said wire to said input/output contact and to said bond pad; and

cutting said wire near said bond pad.

48. The method according to claim 47, wherein said at least one of said devices are hermetically sealed electronics packages further comprising at least one electrode.

49. The method according to claim 47, wherein said bond pads are further comprised of platinum.

50. The method according to claim 47, wherein said biocompatible materials are comprised of platinum.

51. A method of bonding two implantable devices, said method comprising the steps of:

forming a tail-ball with a tail on a wire;

bonding said tail-ball to an input/output contact of a first substrate;

modifying a flexible electrically insulating substrate by forming a through hole adjacent to a bond pad of said second substrate;

aligning said through hole of said second substrate with said tail;

placing said tail through said through hole;

bending said tail to contact said bond pad; and

bonding said tail to said bond pad.

52. The method according to claim 51, wherein said devices are hermetically sealed electronics packages further comprising at least one electrode.

53. The method according to claim 51, wherein said bond pads are further comprised of platinum.

54. The method according to claim 51, wherein said biocompatible materials are comprised of platinum.

55. The method according to claim 51, further comprising the step of welding a locking wire over said tail and said bond pad.