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Cascade polymer complexes, process for their production and pharmaceutical agents containing said complexes

  • US 7,211,241 B2
  • Filed: 10/17/2003
  • Issued: 05/01/2007
  • Est. Priority Date: 07/04/1995
  • Status: Expired due to Fees
First Claim
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1. A method for identification of underperfused regions in a human or animal patient which comprises administering an effective amount of a nitrogen-containing cascade polymer having complexing ligands which complex at least 16 ions of an element of atomic numbers 20–

  • 29, 39, 42, 44 or 57–

    83, and performing NMR diagnosis on the patient to identify the underperfused regions, wherein the nitrogen-containing cascade polymer having complexing ligands is of the following formula (I);


    A—

    {X—

    [Y—

    (Z—

    (W—

    Kw)z)y]x}a



    (I),in whichA stands for a nitrogen-containing cascade nucleus of base multiplicity a;

    X and Y, independently of one another, stand for a direct bond or a cascade reproduction unit of reproduction multiplicity x or y;

    Z and W, independently of one another, stand for a cascade reproduction unit of reproduction multiplicity z or w;

    a stands for numbers 2 to 12;

    x, y, z, and w, independently of one another, stand for numbers 1 to 4, provided that the product of the multiplicities,
    16









    w≦

    64holds true;

    K stands for the radical of a complexing agent of the formula (IA);

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