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Enhancement of transfection of DNA into the liver

  • US 7,211,248 B2
  • Filed: 07/10/2002
  • Issued: 05/01/2007
  • Est. Priority Date: 07/10/2001
  • Status: Expired due to Term
First Claim
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1. A method for in vivo transfection of DNA encoding apo A1 into liver cells of a mammal comprising the steps ofa) delivering a solution containing (i) an ultrasonic contrast agent comprising protein-stabilized gas microspheres, and (ii) plasmid DNA which encodes apo A1 to the vasculature of the liver under pressure;

  • andb) applying ultrasound to the liver during exposure of the liver cells to the solution to induce the transfection of the DNA in the liver cells to increase the level of apo A1 in the blood of the mammal.

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