Optical substance analyzer

• US 7,212,693 B2
• Filed: 12/22/2003
• Issued: 05/01/2007
• Est. Priority Date: 12/22/2003
• Status: Active Grant

• Current Assignee: WSOU Investments, LLC (WSOU Holdings, LLC)
• Original Assignee: Lucent Technologies, Inc. (Nokia Corporation)
• Inventors: Tran, Alex T., Chan, Ho Bun, Carr, Dustin W.
• Primary Examiner(s): Doan, Jennifer
• Application Number:
  US10/743,253
• Publication Number:
  US 20050135723A1
• Time in Patent Office: 1,226 Days
• Field of Search: 385/12, 385/37
• US Class Current: 385/12
• CPC Class Codes: G01N 2021/7709 Distributed reagent, e.g. over length of guide
• CPC Class Codes: G01N 2021/7779 interferometric
• CPC Class Codes: G01N 2021/7793 Sensor comprising plural indicators
• CPC Class Codes: G01N 21/45 using interferometric methods; using Schlieren methods
• CPC Class Codes: G01N 21/774 the reagent being on a grating or periodic structure
• CPC Class Codes: G01N 21/7746 the waveguide coupled to a cavity resonator
• CPC Class Codes: G01N 33/54366 Apparatus specially adapted for solid-phase testing
• CPC Class Codes: G01N 33/569 for microorganisms, e.g. protozoa, bacteria, viruses

Abstract

A portable waveguide sensor having one or more gratings. In one embodiment, the sensor has a waveguide, wherein a plurality of grooves imprinted onto the waveguide form a Bragg grating. The surface of the grooves has a functional layer adapted to bind a substance of interest, e.g., a biological pathogen. When the pathogen binds to the functional layer, the binding shifts the spectral reflection band corresponding to the Bragg grating such that a probe light previously reflected by the grating now passes through the grating, thereby indicating the presence of the pathogen. In another embodiment, the sensor has a Mach-Zehnder interferometer (MZI), one arm of which has a resonator formed by two Bragg gratings. The surface of the resonator between the gratings has a functional layer whereas the Bragg gratings themselves do not have such a layer.

Claims

1. A device, comprising an optical waveguide having a first grating, wherein:

at least a portion of the waveguide has a functional layer adapted to bind an analyte;

a plurality of grooves in the optical waveguide form the first grating;

at least some of the grooves are covered by the functional layer;

when the analyte binds to the functional layer, the binding changes optical characteristics of the waveguide;

the first grating has an optical reflection band characterized by a center wavelength; and

the binding shifts the center wavelength.

2. The device of claim 1, comprising one or more additional optical waveguides, each having a grating, wherein:

each grating has an optical reflection band characterized by a center wavelength; and

at least two gratings have different reflection bands.

3. The device of claim 2, further comprising an arrayed waveguide grating (AWG) having an input port and two or more output ports coupled to the two or more optical waveguides, wherein, for each optical waveguide, the AWG is adapted to route light having a corresponding center wavelength from the input port to the output port coupled to said optical waveguide.

4. The device of claim 3, wherein the AWG and the two or more optical waveguides are implemented in a single integrated device.

5. The device of claim 2, wherein at least two optical waveguides have different functional layers adapted to bind different analytes.

6. The device of claim 1, comprising a Mach-Zehnder interferometer (MZI) having two arms, wherein one arm includes the optical waveguide.

7. The device of claim 6, wherein:

the optical waveguide has a second grating; and

the first and second gratings form an optical resonator.

8. The device of claim 7, wherein:

a section of the optical waveguide between the first and second gratings has the functional layer; and

the binding changes a differential phase shift in the MZI.

9. The device of claim 1, wherein the first grating is a Bragg grating.

10. A method for detecting an analyte, comprising:

transmitting light through an optical waveguide having a first grating; and

measuring the transmitted light using a photo-detector, wherein;

at least a portion of the waveguide has a functional layer adapted to bind the analyte;

a plurality of grooves in the optical waveguide form the first grating; and

at least some of the grooves are covered by the functional layer;

when the analyte binds to the functional layer, the binding changes optical characteristics of the waveguide;

the first grating has an optical reflection band characterized by a center wavelength; and

the binding shifts the center wavelength.

11. The method of claim 10, wherein the first grating is a Bragg grating.

12. The method of claim 10, further comprising

transmitting light through one or more additional optical waveguides, each having a grating;

and

measuring the transmitted light using a plurality of photo-detectors, wherein;

each grating has an optical reflection band characterized by a center wavelength; and

at least two gratings have different reflection bands.

13. The method of claim 12, further comprising routing light via an arrayed waveguide grating (AWG) having an input port and two or more output ports coupled to the two or more optical waveguides, wherein, for each optical waveguide, the AWG is adapted to route light having a corresponding center wavelength from the input port to the output port coupled to said optical waveguide.

14. The method of claim 12, wherein at least two optical waveguides have different functional layers adapted to bind different analytes.

15. The method of claim 10, wherein the optical waveguide is a part of one arm of a Mach-Zehnder interferometer (MZI).

16. The method of claim 15, wherein:

the optical waveguide has a second grating; and

the first and second gratings form an optical resonator.

17. The method of claim 16, wherein:

a section of the optical waveguide between the first and second gratings is covered by the functional layer;

the binding changes a differential phase shift in the MZI; and

measuring the transmitted light comprises measuring the differential phase shift.

18. A device, comprising a Mach-Zehnder interferometer (MZI) having two arms, wherein:

one arm has an optical resonator; and

a section of the resonator has a functional layer adapted to bind an analyte, wherein the optical characteristics of the resonator change, when the analyte binds to the functional layer.

19. The device of claim 18, wherein:

two Bragg gratings form the optical resonator;

the section having the functional layer is located between the gratings; and

the binding changes a differential phase shift in the MZI.

20. The device of claim 18, wherein the optical resonator is formed by two gratings adapted to couple light in and out of the optical resonator and to generate multiple round trips of the light within the resonator.

21. A device, comprising an optical waveguide having a first grating, wherein:

at least a portion of the waveguide has a functional layer adapted to bind an analyte;

when the analyte binds to the functional layer, the binding changes optical characteristics of the waveguide;

the device further comprises one or more other optical waveguides, each having a grating, wherein;

each grating has an optical reflection band characterized by a center wavelength; and

at least two gratings have different reflection bands; and

the device further comprises an arrayed waveguide grating (AWG) having an input port and two or more output ports coupled to the two or more optical waveguides, wherein, for each optical waveguide, the AWG is adapted to route light having a corresponding center wavelength from the input port to the output port coupled to said optical waveguide.

22. The device of claim 21, wherein the AWG and the two or more optical waveguides are implemented in a single integrated device.

23. The device of claim 21, wherein at least two optical waveguides have different functional layers adapted to bind different analytes.

24. A method for detecting an analyte, comprising:

transmitting light through an optical waveguide having a first grating;

measuring the transmitted light using a photo-detector, wherein;

at least a portion of the waveguide has a functional layer adapted to bind the analyte; and

when the analyte binds to the functional layer, the binding changes optical characteristics of the waveguide;

transmitting light through one or more other optical waveguides, each having a grating;

measuring the transmitted light using a plurality of photo-detectors, wherein;

each grating has an optical reflection band characterized by a center wavelength; and

at least two gratings have different reflection bands; and

routing light via an arrayed waveauide grating (AWG) having an input port and two or more output ports coupled to the two or more optical waveguides, wherein, for each optical waveguide, the AWG is adapted to route light having a corresponding center wavelength from the input port to the output port coupled to said optical waveguide.

25. The method of claim 24, wherein at least two optical waveguides have different functional layers adapted to bind different analytes.

26. A device, comprising an optical waveguide having a first grating, wherein:

at least a portion of the waveguide has a functional layer adapted to bind an analyte;

when the analyte binds to the functional layer, the binding changes optical characteristics of the waveguide; and

the device comprises a Mach-Zehnder interferometer (MZI) having two arms, wherein one arm includes the optical waveguide, wherein;

the optical waveguide has a second grating; and

the first and second gratings form an optical resonator.

27. The device of claim 26, wherein the first and second gratings are adapted to couple light in and out of the optical resonator and to generate multiple round trips of the light within the resonator.

28. The device of claim 26, wherein:

a section of the optical waveguide between the first and second gratings has the functional layer; and

the binding changes a differential phase shift in the MZI.

29. A method for detecting an analyte, comprising:

transmitting light through an optical waveguide having a first grating; and

measuring the transmitted light using a photo-detector, wherein;

at least a portion of the waveguide has a functional layer adapted to bind the analyte;

the optical waveguide is a part of one arm of a Mach-Zehnder interferometer (MZI);

the optical waveguide has a second grating;

the first and second gratings form an optical resonator; and

when the analyte binds to the functional layer, the binding changes optical characteristics of the waveguide.

30. The method of claim 29, wherein the first and second gratings are adapted to couple light in and out of the optical resonator and to generate multiple round trips of the light within the resonator.

31. The method of claim 29, wherein:

a section of the optical waveguide between the first and second gratings is covered by the functional layer;

the binding changes a differential phase shift in the MZI; and

measuring the transmitted light comprises measuring the differential phase shift.

32. A device, comprising an optical waveguide having a first grating, wherein:

at least a portion of the waveguide has a functional layer adapted to bind an analyte;

when the analyte binds to the functional layer, the binding changes optical characteristics of the waveguide; and

the device further comprises one or more other optical waveguides, each having a grating, wherein;

each grating has an optical reflection band characterized by a center wavelength;

at least two gratings have different reflection bands; and

at least two optical waveguides have different functional layers adapted to bind different analytes.

33. A method for detecting an analyte, comprising:

transmitting light through an optical waveguide having a first grating;

measuring the transmitted light using a photo-detector, wherein;

at least a portion of the waveguide has a functional layer adapted to bind the analyte; and

when the analyte binds to the functional layer, the binding changes optical characteristics of the waveguide;

transmitting light through one or more other optical waveguides, each having a grating; and

measuring the transmitted light using a plurality of photo-detectors, wherein;

each grating has an optical reflection band characterized by a center wavelength;

at least two gratings have different reflection bands; and

at least two optical waveguides have different functional layers adapted to bind different analytes.

34. A device, comprising:

an optical waveguide having a first grating; and

a Mach-Zehnder interferometer (MZI) having two arms, wherein;

at least a portion of the waveguide has a functional layer adapted to bind an analyte;

a plurality of grooves in the optical waveguide form the first grating;

at least some of the grooves are covered by the functional layer;

when the analyte binds to the functional layer, the binding changes optical characteristics of the waveguide; and

one arm includes the optical waveguide.

35. The device of claim 34, wherein:

the optical waveguide has a second grating; and

the first and second gratings form an optical resonator.

36. The device of claim 35, wherein:

a section of the optical waveguide between the first and second gratings has the functional layer; and

the binding changes a differential phase shift in the MZI.

37. A method for detecting an analyte, comprising:

transmitting light through an optical waveguide having a first grating; and

measuring the transmitted light using a photo-detector, wherein;

at least a portion of the waveguide has a functional layer adapted to bind the analyte;

a plurality of grooves in the optical waveguide form the first grating; and

at least some of the grooves are covered by the functional layer;

when the analyte binds to the functional layer, the binding changes optical characteristics of the waveguides; and

the optical waveguide is a part of one arm of a Mach-Zehnder interferometer (MZI).

38. The method of claim 37, wherein:

the optical waveguide has a second grating; and

the first and second gratings form an optical resonator.

39. The method of claim 38, wherein:

a section of the optical waveguide between the first and second gratings is covered by the functional layer;

the binding changes a differential phase shift in the MZI; and

,

measuring the transmitted light comprises measuring the differential phase shift.