Cardiac stimulation device including sleep apnea prevention and treatment

• US 7,212,862 B2
• Filed: 09/18/2002
• Issued: 05/01/2007
• Est. Priority Date: 02/14/2002
• Status: Expired due to Term

• Current Assignee: Pacesetter Incorporated (Abbott Laboratories)
• Original Assignee: Pacesetter Incorporated (Abbott Laboratories)
• Inventors: Koh, Steve, Bornzin, Gene A., Park, Euljoon
• Primary Examiner(s): EVANISKO, GEORGE ROBERT
• Application Number:
  US10/247,137
• Publication Number:
  US 20030153956A1
• Time in Patent Office: 1,686 Days
• Field of Search: 607/9, 607/42, 607 17- 28
• US Class Current: 607/24
• CPC Class Codes: A61N 1/3601 of respiratory organs
• CPC Class Codes: A61N 1/36542 controlled by body motion, e.g. acceleration
• CPC Class Codes: A61N 1/36557 controlled by chemical substances in blood
• CPC Class Codes: A61N 1/36585 controlled by two or more physical parameters

Abstract

An implantable cardiac stimulation device comprises a physiologic sensor and one or more pulse generators. The physiologic sensor is capable of sensing a physiologic parameter. The pulse generators can generate cardiac pacing pulses with a timing based on the physiologic parameter. The timed cardiac pacing pulses can prevent a sleep apnea condition. In one example, a cardiac stimulation device has a physiologic sensor and can be configured to pace a patient'"'"'s heart according to a rest mode of operation. The cardiac stimulation device uses measurements from the physiologic sensor to prevent and treat sleep apnea using a revised rest mode of operation. The revised rest mode operates under a presumption that sleep apnea is primary to a reduced heart rate, rather than secondary, so that pacing at a rate higher than the natural cardiac rate during sleep will prevent sleep apnea.

Claims

1. An implantable cardiac stimulation device for stimulating a heart of a patient, the device comprising:

at least one physiologic sensor that is capable of sensing at least one of a characteristic of cardiac conductivity, cardiac contractility or stroke volume and generating corresponding sensor output signals;

one or more pulse generators that are capable of generating cardiac pacing pulses; and

circuitry coupled to the at least one sensor and that is operative to detect a rest condition of the patient based on the sensor output signals and to control the one or more pulse generators to pace the heart at a rest rate, wherein the rest rate is initially set to a first value, wherein the circuitry is further operative to adjust the rest rate to a sleep apnea prevention value based on the signals, wherein the sleep apnea prevention value is higher than the first value.

2. An implantable cardiac stimulation device according to claim 1 further comprising:

a controller coupled to the one or more pulse generators and to the one or more physiologic sensors, the controller comprising an executable control logic that distinguishes between a sleeping condition and a waking condition of a patient and wherein the circuitry adjusts the rest rate to a sleep apnea prevention value in response to the detection a sleeping condition.

3. An implantable cardiac stimulation device according to claim 1 further comprising:

a physiologic sensor that measures physical motion for derivation of an activity parameter and an activity variance parameter, and activates sleep apnea preventive pacing when the activity and activity variance signals indicate a sleeping condition.

4. An implantable cardiac stimulation device according to claim 1 wherein the at least one physiologic sensor comprises a physiologic sensor that measures cardiac conductivity, and wherein the circuitry adjusts the rest rate to the sleep apnea prevention value when cardiac conductivity is depressed during sleep.

5. An implantable cardiac stimulation device according to claim 1 wherein the circuitry adjusts the rest rate to the sleep apnea prevention value when cardiac contractility is reduced during sleep.

6. An implantable cardiac stimulation device according to claim 1 wherein the circuitry adjusts the rest rate to the sleep apnea prevention value when stroke volume increases when a patient is in a supine position.

7. An implantable cardiac stimulation device according to claim 1 further comprising:

a physiologic sensor that measures blood oxygen concentration, and wherein the circuitry adjusts the rest rate to the sleep apnea prevention value when blood oxygen concentration is depressed during sleep.

8. An implantable cardiac stimulation device according to claim 1 further comprising:

a physiologic sensor that measures blood carbon dioxide concentration, and wherein the circuitry adjusts the rest rate to the sleep apnea prevention value when blood carbon dioxide concentration is elevated during sleep.

9. The implantable cardiac stimulation device of claim 1 wherein the circuitry is further operative to determine if the patient experiences an episode of sleep apnea based on the sensor output signals and wherein the circuitry is further operative to adjust the rest rate to a sleep apnea prevention value responsive to the detection of at least one sleep apnea episode.

10. An implantable cardiac stimulation device comprising:

means for setting a rest rate to a first value for a patient;

means for measuring at least one of a characteristic cardiac contractility, cardiac conductivity or stroke volume and for generating corresponding signals; and

means for adjusting the rest rate to a sleep apnea prevention value as a function of the corresponding signals from the measuring means, wherein the sleep apnea prevention value is higher than the first value.

11. An implantable cardiac stimulation device according to claim 10 further comprising:

means for measuring physical motion for derivation of an activity parameter and an activity variance parameter and for distinguishing between a sleeping condition and a waking condition of a patient as a function of the measured activity parameter and activity variance parameter.

12. An implantable cardiac stimulation device according to claim 10 wherein the means for measuring comprises at least one of:

a physiologic sensor that measures cardiac conductivity;

a physiologic sensor that measures cardiac contractility; and

a physiologic sensor that measures stroke volume.

13. A method of operating an implantable cardiac stimulation device, the method comprising:

setting a rest rate to a first value for a patient;

measuring at least one of a characteristic of cardiac contractility, cardiac conductivity or stroke volume and for generating corresponding sensor output signals; and

adjusting the rest rate to a sleep apnea prevention value as a function of the sensor output signals, where the sleep apnea prevention value is higher than the first value.

14. The method of claim 13, further comprising:

distinguishing between a sleeping condition and a waking condition of a patient;

timing generation of cardiac pacing pulses; and

controlling the timed cardiac pacing pulses at a sleep apnea prevention rate.

15. The method of claim 13, wherein adjusting comprises adjusting the rest rate when the cardiac conductivity is depressed during sleep.