Vascular testing system

• US 7,214,192 B2
• Filed: 09/07/2004
• Issued: 05/08/2007
• Est. Priority Date: 09/07/2004
• Status: Active Grant

• Current Assignee: Collaborative Care Diagnostics LLC
• Original Assignee: Biomedix, Inc.
• Inventors: Romans, John Alexander, Glava, Victor Florin, Blanch, Gary Warner, Karels, Andrew Paul, Poliac, Marius, Ince, Daniel James, Steaderman, Charles Fredrec, Rogers, William Lee, Siers, Michael Jerome, Grave, Ricky Lee
• Primary Examiner(s): Nasser; Robert L.
• Assistant Examiner(s): Natnithithadha; Navin
• Application Number:
  US10/935,702
• Publication Number:
  US 20060052714A1
• Time in Patent Office: 973 Days
• Field of Search: 600/481, 600/483, 600/484, 600/485, 600/488, 600490-504
• US Class Current: 600/490
• CPC Class Codes: A61B 5/02141 Details of apparatus construction, e.g. pump units or housings therefor, cuff pressurising systems, arrangements of fluid conduits or circuits A61B5/02233, A61B5/0235 take precedence
• CPC Class Codes: A61B 5/022 by applying pressure to close blood vessels, e.g. against the skin; Ophthalmodynamometers
• CPC Class Codes: A61B 5/02225 using the oscillometric method

Abstract

A method of vascular testing includes inflating a cuff at a vascular location, controllably deflating the cuff, producing a pressure waveform while deflating the cuff, and producing an output representing a pressure at which blood flow returns, while deflating the cuff, based upon analysis of the pressure waveform. Further, a testing system for measuring vascular pressures according to the present invention includes a pressure applicator, a pressure sensor, and a diagnostic test unit. The pressure applicator is positionable along exterior portions of a human body for dynamically applying pressure to a desired vascular location. The pressure sensor is capable of detecting oscillations in a pressure at the pressure applicator. The testing system is capable of determining a peak pressure oscillation amplitude, and is also capable of determining, as a function of the peak pressure oscillation amplitude, a pressure of a return of flow at the desired vascular location as pressure applied to the desired vascular location by the pressure applicator is lessened.

Claims

1. A method of vascular testing, the method comprising:

inflating a cuff at a vascular location;

controllably deflating the cuff;

producing a pressure waveform while deflating the cuff; and

producing an output representing a pressure at a return of blood flow, while deflating the cuff, based upon analysis of the pressure waveform, wherein the output represents a pressure that corresponds to an oscillation amplitude of about seventy-five percent (75%) of a peak oscillation amplitude derived from a portion of a pressure oscillation waveform in which pressure values are generally greater than a pressure value corresponding to the peak oscillation amplitude.

2. The method of claim 1, wherein the pressure waveform is an oscillometric pressure waveform.

3. The method of claim 1 and further comprising the step of:

adjusting the pressure waveform to compensate for non-physiological effects of controllably deflating the cuff.

4. A testing system for measuring vascular pressures, the testing system comprising:

a pressure applicator positionable along exterior portions of a human body, for dynamically applying pressure to a desired vascular location;

a pressure sensor capable of detecting oscillations in a pressure at the pressure applicator; and

means for determining, as a function of a peak pressure oscillation amplitude, a pressure at a return of blood flow at the desired vascular location as pressure applied to the desired vascular location by the oscillometric pressure applicator is lessened, wherein the pressure at the return of blood flow at the desired vascular location corresponds to an oscillation amplitude of about seventy-five percent (75%) of the peak pressure oscillation amplitude at a first portion of a waveform representing detected pressure oscillation amplitude and wherein the first portion of the waveform has pressure values that are generally greater than a pressure value corresponding to the peak pressure oscillation amplitude.

5. The testing system of claim 4 and further comprising:

a first system interface capable of communicating with the means for determining the pressure at the return of blood flow via the Internet.

6. The testing system of claim 5 and further comprising:

a second system interface, wherein the first and second interfaces have different authorities to edit information stored in a common database.

7. The testing system of claim 4, wherein the pressure sensor does not contact a patient'"'"'s body.

8. The testing system of claim 4, wherein the means for determining the pressure at the return of blood flow is capable of sequentially gathering blood pressure data from multiple vascular locations and associating each gathered blood pressure value with a vascular location where gathered.

9. The system of claim 4, wherein the means for determining, as a function of a peak pressure oscillation amplitude, a pressure at a return of blood flow is capable of compensating for artifacts produced in sensed pressure values as pressure applied to the desired vascular location by the oscillometric pressure applicator is lessened.

10. A method of vascular testing, the method comprising:

inflating a cuff to occlude blood flow;

deflating the cuff over a time period;

sensing cuff pressure to produce an pressure signal representing pressure as a function of time, during the time period;

deriving from the pressure signal a relationship of oscillation amplitude as a function of cuff pressure; and

determining a pressure at a return of blood flow based upon the relationship of oscillation amplitude as a function of cuff pressure, wherein the pressure at the return of blood flow is determined at a pressure corresponding to an oscillation amplitude of seventy-five percent (75%) of the peak pressure oscillation amplitude at a high pressure portion of a waveform representing oscillation amplitude, and wherein the high pressure portion of the waveform is defined at pressure that are greater than a pressure corresponding to the peak pressure oscillation amplitude.

11. The method of claim 10, wherein the pressure signal is an oscillometric pressure signal.

12. A method for deriving vascular pressures, the method comprising:

providing an applied pressure higher than a patient'"'"'s systolic blood pressure to a vascular location;

decreasing the applied pressure;

detecting oscillations in a pressure measurement taken at the vascular location, wherein the pressure measurement includes vascular pressures and the applied pressure;

determining a peak oscillation amplitude of oscillations in the pressure measurement; and

deriving a measured pressure at a return of blood flow at the vascular location as a function of the peak oscillation amplitude of the oscillations in the pressure measurement, wherein the measured pressure at the return of blood flow is a pressure corresponding to an oscillation amplitude of about seventy-five percent (75%) of the peak value of the amplitude of the oscillations in the pressure measurement and has a pressure value greater than a pressure value corresponding to the peak value of the amplitude of die oscillations in the pressure measurement.

13. The method of claim 12 and further comprising the step of:

adjusting the pressure measurement to compensate for bleed rate effects from the step of decreasing the applied pressure.

14. A method of vascular testing, the method comprising:

inflating a cuff to a pressure that occludes blood flow;

decreasing cuff pressure;

sensing cuff pressure to produce a signal representing cult pressure as a function of time as the cuff pressure is decreased;

deriving, from the signal, amplitudes of oscillations as a function of cuff pressure;

determining a peak oscillation implitude of the derived oscillations;

determining a cuff pressure associated with a derived oscillation amplitude that is about seventy-five percent (75%) of the peak oscillation amplitude at a pressure higher than a pressure corresponding to the peak oscillation amplitude; and

producing an output representing a pressure at a return of bloodflow as a function of the cuff pressure associated with the derived oscillation amplitude.

15. The method of claim 14 and further comprising the step of:

adjusting the signal to compensate for non-physiological effects of the step of decreasing cuff pressure.

16. A testing system comprising:

a cuff;

a pressure sensor for sensing cuff pressure;

means for deriving an oscillometric signal from the sensed cuff pressure; and

means for deriving from the oscillometric signal a pressure at a return of blood flow, wherein the pressure at the return of blood flow corresponds to an oscillation amplitude of about seventy-five percent (75%) of a peak pressure oscillation amplitude of the oscillometric signal at a pressure that is greater than a pressure corresponding to the peak pressure oscillation amplitude.

17. The testing system of claim 16 and further comprising:

a first system interface capable of communicating with the means for deriving the pressure at the return of blood flow via the Internet.

18. The testing system of claim 17 and further comprising:

a second system interface, wherein the first and second interfaces have different authorities to edit information stored in a common database.

19. The testing system of claim 16, wherein the pressure sensor does not contact a patient'"'"'s body.

20. The testing system of claim 16, wherein the means for deriving the pressure at the return of blood flow is capable of sequentially gathering blood pressure data from multiple vascular locations and associating each gathered blood pressure value with a vascular location where gathered.

21. The system of claim 16, wherein the means for deriving from the oscillometric signal a pressure at a return of blood flow is capable of adjusting the oscillometric signal to compensate for non-physiological artifacts in the sensed cuff pressure.