Method of delivering a TNF antagonist to the brain of a human by perispinal administration without direct intrathecal injection
First Claim
1. A method for delivering a TNF antagonist to the brain of a human for treating Alzheimer'"'"'s related dementia, comprising administering the TNF antagonist etanercept parenterally into the perispinal space of said human without direct intrathecal injection, and thereafter positioning said human in a Trendelenburg position, for delivery of said TNF antagonist etanercept to the brain via the human'"'"'s vertebral venous system (VVS).
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Abstract
The present invention provides specific methods of using and administering etanercept to improve cognitive function in a human, for both the treatment and prevention of cognitive impairment, or, alternatively, to enhance cognitive function including Alzheimer'"'"'s Disease, Idiopathic Dementia, and Traumatic Brain Injury. The methods of the present invention include the perispinal administration of etanercept. For the purposes of this patent “perispinal” is to be considered as referring to “perispinal extrathecal;” therefore direct intrathecal administration is excluded. Perispinal administration leads to enhanced delivery of etanercept to the brain in a therapeutically effective amount, via the vertebral venous system and/or the cerebrospinal fluid. Delivery of etanercept to the brain utilizing the methods of the present invention includes the use of the vertebral venous system to deliver etanercept to the brain via retrograde venous flow. Physical maneuvers are used to enhance delivery of etanercept to the brain via this route.
89 Citations
31 Claims
- 1. A method for delivering a TNF antagonist to the brain of a human for treating Alzheimer'"'"'s related dementia, comprising administering the TNF antagonist etanercept parenterally into the perispinal space of said human without direct intrathecal injection, and thereafter positioning said human in a Trendelenburg position, for delivery of said TNF antagonist etanercept to the brain via the human'"'"'s vertebral venous system (VVS).
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6. A method for delivering etanercept to a human with Alzheimer'"'"'s related dementia, comprising:
- perispinally administering an amount of a TNF antagonist etanercept to the human without direct intrathecal injection, and wherein said perispinal administration results in retrograde delivery of the TNF antagonist etanercept to the brain via the human'"'"'s vertebral venous system in an amount of TNF antagonist etanercept to the brain effective to treat Alzheimer'"'"'s related dementia.
- View Dependent Claims (7, 8, 9, 10, 11)
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12. A method of delivering the TNF antagonist etanercept to the brain of a human, comprising administering said etanercept into the perispinal space of the human without direct intrathecal injection, and thereafter positioning said human in a Trendelenburg position to enable said etanercept to reach the brain via the human'"'"'s vertebral venous system (VVS).
- 13. A method of delivering the TNF antagonist etanercept to the brain of a human, comprising administering said etanercept into the perispinal space of the human without direct intrathecal injection, and then positioning the plane of said human'"'"'s head below horizontal.
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16. A method of delivering etanercept to the brain of a human, comprising administering said etanercept into the perispinal space of said human without direct intrathecal injection;
- and positioning of said human with the head downward below horizontal to facilitate retrograde flow of said etanercept to the brain.
- View Dependent Claims (17)
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18. A method for delivering the TNF antagonist etanercept to the cerebrospinal fluid of a human, comprising administering said etanercept parenterally into the perispinal space of said human without direct inthrathecal injection, and thereafter positioning said human in a Trendelenburg position for delivery of said etanercept to the cerebrospinal fluid.
- 19. A method for delivering a TNF antagonist to the brain of a human for treating mild cognitive impairment, Alzheimer'"'"'s related dementia, or vascular dementia, comprising administering the TNF antagonist etanercept parenterally into the perispinal space of said human without direct intrathecal injection, and thereafter positioning said human in a Trendelenburg position, for delivery of said etanercept to the brain via the human'"'"'s vertebral venous system (VVS).
- 21. A method for delivering a TNF antagonist etanercept to the brain of a human for treating Alzheimer'"'"'s related dementia, comprising administering the TNF antagonist etanercept parenterally into the perispinal space of said human without direct intrathecal injection, and thereafter positioning said human in a Trendelenburg position, for delivery of said TNF antagonist etanercept to the brain.
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23. A method for delivering a TNF antagonist etanercept to the brain of a human for treating mild cognitive impairment, Alzheimer'"'"'s related dementia, or vascular dementia, comprising administering the TNF antagonist etanercept parenterally into the perispinal space of said human without direct intrathecal injection, and thereafter positioning said human in a Trendelenburg position, for delivery of said etanercept to the brain.
- 24. A method for delivering a TNF antagonist etanercept to the brain of a human for treating a TNF mediated dementia, comprising administering the TNF antagonist etanercept parenterally into the perispinal space of said human without direct intrathecal injection, and thereafter positioning said human in a Trendelenburg position, for delivery of said TNF antagonist etanercept to the brain via the human'"'"'s vertebral venous system (VVS).
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26. A method for delivering etanercept to a human with Alzheimer'"'"'s related dementia, comprising administering said etanercept parenterally into the perispinal space of said human without direct intrathecal injection, and thereafter positioning said human in a Trendelenburg position.
- 27. A method for delivering etanercept to a human, comprising administering said etanercept parenterally into the perispinal space of said human without direct intrathecal injection, and thereafter positioning said human in a Trendelenburg position.
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29. A method for delivering etanercept to a human with Alzheimer'"'"'s related dementia, comprising administering said etanercept parenterally into the perispinal space of said human without direct intrathecal injection;
- and then positioning the plane of said human'"'"'s head below horizontal after administration of said etanercept.
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30. A method for delivering etanercept to a human with Alzheimer'"'"'s disease, comprising administering said etanercept parenterally into the perispinal space of said human without direct intrathecal injection, and thereafter positioning said human in a Trendelenburg position.
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31. A method for delivering a TNF antagonist to the brain of a human for treating Alzheimer'"'"'s related dementia, comprising administering the TNF antagonist etanercept parenterally into the perispinal space of said human without direct intrathecal injection, and thereafter positioning the plane of the human'"'"'s head below horizontal, for delivery of said TNF antagonist etanercept to the brain.
Specification