Bi-ventricular heart stimulating device, system and method

• US 7,215,996 B2
• Filed: 10/04/2002
• Issued: 05/08/2007
• Est. Priority Date: 12/19/2001
• Status: Active Grant

• Current Assignee: St. Jude Medical AB (Abbott Laboratories Incorporated)
• Original Assignee: St. Jude Medical AB (Abbott Laboratories Incorporated)
• Inventors: Noren, Kjell, Bjorling, Anders, Ljungstrom, Karin, Kalling, Sven, Mandal, Lars
• Primary Examiner(s): Pezzuto; Robert E.
• Assistant Examiner(s): JOHNSON, SHEVON ELIZABETH
• Application Number:
  US10/499,253
• Publication Number:
  US 20050125042A1
• Time in Patent Office: 1,677 Days
• Field of Search: 607/9, 607 17- 18, 607/25
• US Class Current: 607/17
• CPC Class Codes: A61N 1/3627 for treating a mechanical deficiency of the heart, e.g. congestive heart failure or cardiomyopathy
• CPC Class Codes: A61N 1/36521 the parameter being derived from measurement of an electrical impedance
• CPC Class Codes: A61N 1/3682 with a variable atrioventricular delay
• CPC Class Codes: A61N 1/3684 for stimulating the heart at multiple sites of the ventricle or the atrium
• CPC Class Codes: A61N 1/36843 Bi-ventricular stimulation

Abstract

In an implantable heart stimulating device, system and method, electrical stimulation pulses are delivered to first and second ventricles of a heart with a variable time interval therebetween, and signals are sensed at two different positions in the heart, from which an impedance value is derived. A minimum value and a maximum value of the impedance value are determined during a heart cycle, and a relationship between the minimum and maximum values also is determined. The time interval is varied and the relationship is monitored over a number of heart cycles. The time interval is set so that the relationship satisfies a predetermined requirement.

Claims

1. An implantable heart stimulating device comprising:

a housing adapted for implantation in a subject;

a pulse generator contained in said housing for interacting with a first ventricle and a second ventricle of a heart of the subject to stimulate said first ventricle and said second ventricle;

sensing circuitry contained in said housing adapted to obtain sensed signals from two different positions relative to the heart; and

a control circuit contained in said housing and connected to said pulse generator and to said sensing circuitry, said control circuit controlling said pulse generator to emit respective stimulating pulses to the first and second ventricles within a same heart cycle with a time interval between the respective pulses that is variable by said control circuit, said control circuit receiving said sensed signals from said sensing circuitry and deriving an impedance value therefrom indicative of an impedance between said two different positions, said control circuit determining a minimum value magnitude and a maximum value magnitude of said impedance value during said heart cycle and determining a relationship between said minimum value magnitude and said maximum value magnitude, said control circuit varying said time interval and monitoring said relationship over a plurality of heart cycles, and said control circuit setting said time interval to cause said relationship to satisfy a predetermined requirement.

2. An implantable heart stimulating device as claimed in claim 1, wherein said control circuit forms a ratio of said minimum value magnitude and said maximum value magnitude as said relationship.

3. An implantable heart stimulating device as claimed in claim 2 wherein said predetermined requirement is that said ratio is minimized.

4. An implantable heart stimulating device as claimed in claim 1 wherein said control circuit forms a difference between said minimum value magnitude and said maximum value magnitude in determining said relationship.

5. An implantable heart stimulating device as claimed in claim 4 wherein said control circuit forms a ratio between said minimum value magnitude and said difference as said relationship.

6. An implantable heart stimulating device as claimed in claim 5 wherein said predetermined requirement is that said ratio is minimized.

7. An implantable heart stimulating device as claimed in claim 6 wherein said control circuit changes said time interval in a first direction selected from the group consisting of increasing said time interval and decreasing said time interval, and monitors a change in said ratio when said time interval is changed in said first direction and, if said ratio decreases, said control circuit further changing said time interval in said first direction until said predetermined requirement is satisfied.

8. An implantable heart stimulating device as claimed in claim 7 wherein said control circuit, if said ratio increases, changes said time interval in a direction opposite to said first direction, and further changes said time interval in said opposite direction until said predetermined requirement is satisfied.

9. An implantable heart stimulating device as claimed in claim 1 further comprising an activity sensor adapted to interact with the subject to obtain an activity signal indicative of a level of physical activity of the subject, and wherein said control circuit varies said time interval and monitors said relationship over a plurality of heart cycles and sets said time interval to cause said relationship to satisfy said predetermined requirement when said activity signal indicates said subject is at a low level of physical activity.

10. An implantable heart stimulating device as claimed in claim 1 wherein said pulse generator is also adapted to interact with an atrium of the heart to deliver stimulation pulses to the atrium, and wherein said control circuit controls delivery of respective stimulating pulses delivered to the atrium and to said ventricles with a variable atrial-ventricular delay, and wherein said control circuit, while maintaining said time interval at the set value, varies said atrial-ventricular delay and monitors said relationship over a plurality of heart cycles, and sets said atrial-ventricular delay to cause said relationship to satisfy said predetermined requirement.

11. An implantable heart stimulating system comprising:

a housing adapted for implantation in a subject;

a pulse generator contained in said housing for interacting with a first ventricle and a second ventricle of a heart of the subject to stimulate said first ventricle and said second ventricle;

sensing circuitry contained in said housing adapted to obtain sensed signals from two different positions relative to the heart; and

a control circuit contained in said housing and connected to said pulse generator and to said sensing circuitry, said control circuit controlling said pulse generator to emit respective stimulating pulses to the first and second ventricles within a same heart cycle with a time interval between the respective pulses that is variable by said control circuit, said control circuit receiving said sensed signals from said sensing circuitry and deriving an impedance value therefrom indicative of an impedance between said two different positions, said control circuit determining a minimum value magnitude and a maximum value magnitude of said impedance value during said heart cycle and determining a relationship between said minimum value magnitude and said maximum value magnitude, said control circuit varying said time interval and monitoring said relationship over a plurality of heart cycles, and said control circuit setting said time interval to cause said relationship to satisfy a predetermined requirement.

12. A heart stimulating system as claimed in claim 11 wherein said first lead carries said first sensing electrode and wherein said second lead carries said second sensing electrode.

13. A method for stimulating a heart comprising the steps of:

with a pulse generator contained in a housing implanted in a subject, stimulating a first ventricle and a second ventricle of a heart of the subject;

with sensing circuitry contained in said housing, obtaining sensed signals from two different positions relative to the heart; and

with a control circuit contained in said housing and connected to said pulse generator and to said sensing circuitry, controlling said pulse generator to emit respective stimulating pulses to the first and second ventricles within a same heart cycle with a time interval between the respective pulses that is variable by said control circuit, said control circuit receiving said sensed signals from said sensing circuitry and deriving an impedance value therefrom indicative of an impedance between said two different positions, determining a minimum value magnitude and a maximum value magnitude of said impedance value during said heart cycle and determining a relationship between said minimum value magnitude and said maximum value magnitude, and varying said time interval and monitoring said relationship over a plurality of heart cycles, and setting said time interval to cause said relationship to satisfy a predetermined requirement.

14. A method as claimed in claim 13 wherein the step of sensing said impedance between said two positions comprises sensing said impedance across at least a portion of one of said first ventricle and said second ventricle.

15. A method as claimed in claim 13 wherein the step of sensing said impedance between said two positions comprises sensing said impedance across a left ventricle of the heart.

16. A method as claimed in claim 13 wherein the step of sensing said impedance between said two positions comprises sensing said impedance across at least a part of a left atrium of the heart.