Synchronous pacemaker with AV interval optimization

• US 7,215,998 B2
• Filed: 01/05/2004
• Issued: 05/08/2007
• Est. Priority Date: 01/06/2003
• Status: Active Grant

• Current Assignee: Medtronic Incorporated (Medtronic Plc)
• Original Assignee: Medtronic Incorporated (Medtronic Plc)
• Inventors: Van Oort, Geeske, Wesselink, Willem
• Primary Examiner(s): Pezzuto; Robert E.
• Assistant Examiner(s): Heller; Tammie K.
• Application Number:
  US10/751,365
• Publication Number:
  US 20050043764A1
• Time in Patent Office: 1,219 Days
• Field of Search: 607/17, 607/25
• US Class Current: 607/25
• CPC Class Codes: A61N 1/3627 for treating a mechanical deficiency of the heart, e.g. congestive heart failure or cardiomyopathy
• CPC Class Codes: A61N 1/368 comprising more than one electrode co-operating with different heart regions A61N1/3622, A61N1/3627 take precedence
• CPC Class Codes: A61N 1/3682 with a variable atrioventricular delay
• CPC Class Codes: A61N 1/3684 for stimulating the heart at multiple sites of the ventricle or the atrium
• CPC Class Codes: A61N 1/36842 Multi-site stimulation in the same chamber

Abstract

A system and method for use in an implanted cardiac pacing device, whereby an optimal AV delay is determined at or near lower rate (pacing) limit (LRL) by determining measuring the variance, or instability, of the QT interval for a set of intervals. In one embodiment, asynchronous “LRL pacing” with a first programmed AV delay determines a measure of QT variance. The difference between the maximum QT and the minimum QT is expressed as QT difference (QTD). For each programmed AV delay the QT variance is again measured and the optimal AV delay produces minimum QTD. In another embodiment, AV delay is modulated around base values for a time. The difference between QT for the modulated AV and for the base AV (dQT) is measured at each base value, and the optimal AV delay corresponds to the smallest dQT.

Claims

1. An implantable cardiac pacing system capable of delivering atrial pace signals at a determined pacing rate and synchronously generating ventricular pace signals at a determined AV delay following delivery of atrial pacing signals and including an AV delay optimizing subsystem, said AV delay optimizing subsystem comprising:

test means for initiating a test to determine an optimal AV delay corresponding to a pacing rate at about a lower rate limit (LRL);

rate means for setting a cardiac pacing rate at or near the LRL;

AV delay means for varying a AV delay interval value to each one of a plurality of respective AV values and for maintaining the AV delay interval value at each said respective AV value for a time t;

QT means operative during the time t of each maintained AV delay value for measuring variation of QT over said time t and for determining a QT differential (QTD) over said time t; and

optimizing means for determining the optimal AV delay, wherein said optimal AV delay corresponds to a minimal QTD, and for programming said optimal AV delay as an operating AV delay.

2. A system according to claim 1, wherein said QT means comprises means for determining QTmax and QTmin during each said time t and means for determining the difference between QTmax and Qtmin to provide said QTD.

3. A system according to claim 1, comprising timing means for setting said time t to a predetermined value less than about 10 seconds.

4. A system according to claim 1, comprising timing means for setting said time to a predetermined number of discrete cardiac cycles.

5. A system according to claim 1, wherein said AV delay means comprises increment means for setting said AV delay values to a predetermined low value (AVmin) plus an integer (n) multiplied by a difference in time (Δ

T), and program means for programming operating values of AVmin, n and Δ

T.

6. A system according to claim 1, wherein said AV means comprises program means for automatically cycling through each of said plurality of respective AV values.

7. A system according to claim 1, comprising evaluation means for evaluating the minimal value of QTD and for changing the AV delay to the value corresponding said minimal value if said minimal value differs significantly from QTD of the AV value prior to initiating said test.

8. A system according to claim 1, wherein said test means comprises storage means for a storing test criteria and monitoring means for determining that said test criteria are met before initiating a said test.

9. A system according to claim 8, wherein said storage means stores criteria for a pacing mode and a QT stability value.

10. A system according to claim 1, comprising AV(r) means for generating an AV(r) curve based on said optimized AV delay.

11. An implantable pacing system for pacing a patient'"'"'s heart, having means for generating and delivering atrial pace signals at a determined pacing rate and means for generating ventricular pulses at a determined AV delay following an atrial pace event, and including an AV optimizing subsystem, said AV optimizing subsystem comprising:

test means for initiating a test to determine an optimal AV delay corresponding to a pacing rate near a lower rate limit (LRL);

rate means for setting pacing rate near the LRL;

AV delay means for providing a set of respective base values of the AV delay;

setting means for setting a base value of each of the set of respective base values of the AV delay to each respective one of said set of base values and maintaining said base value for a predetermined duration, the test comprising a duration for each of the set of base values;

modulation means for modulating discrete delay intervals to a plurality of test AV delay values, wherein said plurality of test AV delay values are near each of the set of base values during each said duration;

QT variation means operative during each said duration for determining a change in QT (dQT) during the performance of the modulating function by the modulation means for each of the set of base values;

minimum means for determining the minimum dQT from a set of dQT values derived from the set of base values; and

optimizing means for setting an optimal AV to the base AV value corresponding to said minimum dQT.

12. A system according to claim 11, wherein said modulation means comprises a programmable apparatus.

13. A system according to claim 12, wherein said modulation means comprises means for incrementally increasing and decreasing a test AV delay with respect to each of the set of the base values during each duration.

14. A system according to claim 12, wherein said modulation means comprises means for increasing AV delay in n predetermined discrete steps and for decreasing AV delay in n predetermined discrete steps, whereby the AV delay is increased and decreased with respect to the base AV delay during each said duration.

15. A system according to claim 14, wherein said modulation means comprises a programmable storage structure for holding the value of n and the value of said discrete steps, and n=1.

16. A system according to claim 15, where n equals at least 2.

17. A system according to claim 11, wherein said AV means comprises a set of m programmable base values.

18. A system according to claim 17, wherein said optimizing means comprises means for determining when said minimum dQT is significantly different from a prior dQT determined prior to said test, and for not altering a prior operating AV delay when the optimized AV delay it is not significantly different from the prior operating AV delay.

19. A system according to claim 18, comprising means for automatically repeating said test within a predetermined time following a determination that said minimum dQT is not significantly different.

20. A system according to claim 11, further comprising program means for programming said test to be completed in less than about ten minutes.

21. A system according to claim 11, comprising program means for programming each duration to be completed in less than about 10 cardiac cycles.

22. A system according to claim 11, comprising AV(r) means for generating an AV(r) curve that includes said optimal AV delay.