Autologous coatings for implants

• US 7,217,425 B2
• Filed: 01/27/2005
• Issued: 05/15/2007
• Est. Priority Date: 07/23/2004
• Status: Active Grant

• Current Assignee: Depuy Spine Incorporated (Johnson & Johnson)
• Original Assignee: Depuy Spine Incorporated (Johnson & Johnson)
• Inventors: DiMauro, Thomas M., Serhan, Hassan, Kapur, Terri
• Primary Examiner(s): Wax; Robert A.
• Application Number:
  US11/044,388
• Publication Number:
  US 20060019875A1
• Time in Patent Office: 838 Days
• Field of Search: 424/422, 530/395, 435/334
• US Class Current: 424/423
• CPC Class Codes: A61K 38/1709 from mammals
• CPC Class Codes: A61K 38/2066 IL-10
• CPC Class Codes: A61K 38/57 from animals; from humans A61K38/553, A61K38/556 take precedence
• CPC Class Codes: A61L 2300/252 Polypeptides, proteins, e.g. glycoproteins, lipoproteins, cytokines
• CPC Class Codes: A61L 2300/404 Biocides, antimicrobial agents, antiseptic agents
• CPC Class Codes: A61L 2300/41 Anti-inflammatory agents, e.g. NSAIDs
• CPC Class Codes: A61L 2300/426 Immunomodulating agents, i.e. cytokines, interleukins, interferons
• CPC Class Codes: A61L 2300/434 of enzymes
• CPC Class Codes: A61L 2300/606 Coatings
• CPC Class Codes: A61L 2430/38 for reconstruction of the spine, vertebrae or intervertebral discs
• CPC Class Codes: A61L 27/227 Other specific proteins or polypeptides not covered by A61L27/222, A61L27/225 or A61L27/24
• CPC Class Codes: A61L 27/28 Materials for coating prostheses
• CPC Class Codes: A61L 27/54 Biologically active materials, e.g. therapeutic substances A61L27/227 takes precedence
• CPC Class Codes: A61L 29/048 Other specific proteins or polypeptides not covered by A61L29/045 - A61L29/047
• CPC Class Codes: A61L 29/08 Materials for coatings
• CPC Class Codes: A61L 29/16 Biologically active materials, e.g. therapeutic substances A61L29/048 takes precedence

Abstract

A hydrocephalus shunt having an anti-inflammatory coating applied to at least the outside surface of the ventricular catheter. Such coatings are also applicable to other medical devices or implants.

Claims

1. A hydrocephalus shunt having a ventricular catheter wherein adiponectin is present as a coating upon an outer surface of the catheter.

2. The shunt of claim 1 wherein the adiponectin coating is autologous.

3. A hydrocephalus shunt having a ventricular catheter having an outer surface having an anti-microbial coating thereon comprising transferrin.

4. The shunt of claim 3 wherein the transferrin coating is autologous.

5. A kit for treating a hydrocephalus shunt, comprising:

a) a hydrocephalus shunt, and

b) a formulation comprising an effective amount of an anti-inflammatory coating effective for coating the shunt, wherein the coating is adiponectin.

6. The kit of claim 5 wherein the adiponectin coating is autologous.

7. An orthopedic implant having an outer surface having a protein-based, anti-inflammatory coating thereon comprising adiponectin.

8. The implant of claim 7 wherein the anti-inflammatory coating is adiponectin.

9. The implant of claim 8 wherein the adiponectin coating is autologous.

10. The implant of claim 7 wherein the implant is a spinal implant.

11. The implant of claim 10 wherein the spinal implant is selected from the group consisting of a motion implant, a fusion implant and a fixation implant.

12. The implant of claim 11 wherein the spinal implant is a motion implant selected from the group consisting of a lumbar motion disc, a cervical motion disc and a posterior dynamic stabilization device.

13. The implant of claim 11 wherein the spinal implant is a fusion implant selected from the group consisting of a cage and a mesh.

14. The implant of claim 11 wherein the spinal implant is a fixation implant selected from the group consisting of a hook, a rod, a screw, and a scoliosis correction system.

15. The implant of claim 7 wherein the orthopedic implant is a hip implant selected from the group consisting of a modular head, a modular femoral component, and an acetabular cup.

16. The implant of claim 7 wherein the orthopedic implant is a knee implant selected from the group consisting of a tibial component and a femoral component.

17. A method of coating an implant comprising the steps of:

a. providing an unassembled implant,

b. assembling the implant in the patient'"'"'s body, and

c. spraying a coating upon a surface of the assembled implant.

18. A method of treating an implant, comprising the steps of:

a. providing an implant, and

b. spraying a coating upon the implant, wherein the coating contains an effective amount of a compound selected from the group consisting of, transferrin and adiponectin.

19. The method of claim 18 wherein the coating is sprayed upon the implant before implantation.

20. The method of claim 18 wherein the coating is sprayed upon the implant after implantation.