Drug delivery apparatus utilizing cantilever

• US 7,217,428 B2
• Filed: 05/28/2004
• Issued: 05/15/2007
• Est. Priority Date: 05/28/2004
• Status: Expired due to Fees

• Current Assignee: Technology Innovations, LLC
• Original Assignee: Technology Innovations, LLC
• Inventors: Woolf, Nancy J., Tuszynski, Jack
• Primary Examiner(s): Kennedy; Sharon E.
• Application Number:
  US10/857,279
• Publication Number:
  US 20050265991A1
• Time in Patent Office: 1,082 Days
• Field of Search: 424/130.1, 424/408, 424/422, 424/423, 424/427, 424/451, 424/464, 424/468, 514/449, 604/31, 604/502, 604/503, 604/504, 604/66, 604/67, 604/890.1, 604/891.1, 438/49, 438/52, 438/53
• US Class Current: 424/464
• CPC Class Codes: A61K 31/337 having four-membered rings, e.g. taxol

Abstract

Disclosed is a device which employs a chemically sensitive cantilever hingably attached to a capsule. The cantilever functions as a switch which regulates the flow of particles into and/or out of the capsule.

Claims

1. A micro-device comprising a capsule comprised of a cavity, a channel connecting said cavity to an outer surface of said capsule, and a chemically sensitive cantilever, wherein said cantilever is hingably attached to said capsule, and said cantilever substantially blocks said channel, and disposed within said cavity is a taxane.

2. A micro-device as recited in claim 1 wherein said cantilever is coated with receptor particles operatively configured to bind to sensed particles, wherein the receptor particles are antibodies specific for hyperphosphorylated tau protein.

3. A micro-device as recited in claim 2 wherein said sensed particles are comprised of tau protein.

4. A micro-device as recited in claim 1 wherein said cantilever is coated with receptor particles operatively configured to bind to sensed particles and wherein the receptor particles are motor proteins.

5. A micro-device as recited in claim 4 wherein said motor proteins are comprised of kinesin.

6. A micro-device as recited in claim 5 wherein said sensed particles are microtubules.

7. A micro-device comprising a capsule comprised of a cavity, a channel connecting said cavity to an outer surface of said capsule, and a chemically sensitive cantilever, wherein said cantilever is hingably attached to said capsule, and said cantilever substantially blocks said channel, and disposed within said cavity is a taxane.

8. A process for releasing a compound comprising the steps of

a. firstly, contacting a capsule to a first particle, wherein said capsule comprises a cavity, a compound disposed within said cavity, a channel connecting said cavity to an outer environment, a chemically sensitive cantilever substantially blocking said channel, wherein said chemically sensitive cantilever is comprised of a layer of receptor molecules which bind to said first particle,

b. secondly, allowing said first particle to bind to said receptor molecules, thereby causing said chemically sensitive cantilever to bend, thereby substantially unblocking said channel, and

c. thirdly, releasing said compound from said cavity to said outer environment through said channel

wherein said layer of antibodies are operatively configured to bind to hyperphosphorylated tau protein.

9. The process as recited in claim 8, wherein said compound is a taxane.

10. A micro-device comprising a capsule comprised of a cavity, a channel connecting said cavity to an outer surface of said capsule, a chemically sensitive cantilever, and a biologically active compound disposed within said cavity, wherein

a. said cantilever is hingably attached to said capsule,

b. said cantilever blocks said channel, and

c. said cantilever is coated with receptor particles which are operatively configured to bind to sensed particles, thereby causing said cantilever to bend and release said biologically active compound from said cavity wherein said biologically active compound is a taxane.

11. A micro-device as recited in claim 10 wherein said receptor particles are antibodies capable of specifically binding hyperphosphorylated tau protein.

12. A micro-device as recited in claim 10 wherein said sensed particles are tau protein.

13. A micro-device as recited in claim 10 wherein said receptor particles are comprised of motor proteins.

14. A micro-device as recited in claim 13 wherein said motor proteins are comprised of kinesin.

15. A micro-device as recited in claim 14 wherein said sensed particles are microtubules.