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Organotypic intestinal culture and methods of use thereof

  • US 7,217,570 B2
  • Filed: 08/22/2002
  • Issued: 05/15/2007
  • Est. Priority Date: 08/23/2001
  • Status: Expired due to Fees
First Claim
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1. An organotypic culture comprising an artificial stroma comprising a mixture of collagen and human fibroblasts isolated from a human colon or intestine, said stroma overlayed with epithelial cells isolated from fetal human colon, wherein said culture contains a growth factor that binds the insulin growth factor-1 (IGF-1) receptor selected from insulin and IGF-1, a growth factor that binds the epidermal growth factor (EGF) receptor selected from EGF and tumor growth factor-alpha (TGF-alpha), and the growth factor leukemia inhibitory factor (LIF), which binds the LIF receptor.

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