Rapid pharmaceutical identification and verification system
First Claim
1. A method for identifying and verifying a phannaceutical in a prescription vial, comprising:
- storing a plurality of stored spectral signatures corresponding to known pharmaceuticals in a database;
inserting the prescription vial containing the phannaceutical whose identity is to be verified into a sample handling system;
measuring a spectral signature of the pharmaceutical whose identity is to be verified using a multimodal multiplex sampling (MMS) spectrometer;
comparing the measured spectral signature to at least one of the stored spectral signatures;
determining if the measured spectral signature matches one of the stored spectral signatures;
if the measured spectral signature does not match one of the stored spectral signature, reporting that the identity of the pharmaceutical could not be determined; and
if the measured spectral signature matches one of the stored spectral signatures, reporting the identity of the pharmaceutical.
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Abstract
A prescription verification system includes a database that contains a plurality of spectral signatures corresponding to identified pharmaceuticals. A multimodal multiplex sampling (MMS) spectrometer obtains a spectra of a pharmaceutical to be identified and verified. The pharmaceutical can be inside or out of a vial. The prescription verification system includes algorithms for matching spectra of pharmaceuticals to be verified obtaining using the MMS spectrometer to spectral signatures contained in the database corresponding to identified pharmaceuticals. The prescription verification system further includes algorithms for identifying such pharmaceuticals to be verified.
89 Citations
29 Claims
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1. A method for identifying and verifying a phannaceutical in a prescription vial, comprising:
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storing a plurality of stored spectral signatures corresponding to known pharmaceuticals in a database; inserting the prescription vial containing the phannaceutical whose identity is to be verified into a sample handling system; measuring a spectral signature of the pharmaceutical whose identity is to be verified using a multimodal multiplex sampling (MMS) spectrometer; comparing the measured spectral signature to at least one of the stored spectral signatures; determining if the measured spectral signature matches one of the stored spectral signatures; if the measured spectral signature does not match one of the stored spectral signature, reporting that the identity of the pharmaceutical could not be determined; and if the measured spectral signature matches one of the stored spectral signatures, reporting the identity of the pharmaceutical. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10)
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11. A prescription verification system comprising:
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a database containing a plurality of spectral signatures corresponding to identified pharmaceuticals; a multimodal multiplex sampling (MMS) spectrometer; algorithms for matching spectra of pharmaceuticals to be verified obtaining using the MMS spectrometer to spectral signatures contained in the database corresponding to identified pharmaceuticals; and algorithms for identifying such pharmaceuticals to be verified. - View Dependent Claims (12, 13, 14, 15, 16, 17, 18)
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19. A method for identifying pharmaceuticals in a closed vial comprising:
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maintaining a database of known spectral signatures corresponding to known pharmaceuticals; placing the closed vial containing the pharmaceuticals in a spectrometer system; directing a beam of electromagnetic radiation at the pharmaceuticals in the closed vial though the side, the bottom or the top of the closed vial; measuring a spectral signature from the electromagnetic radiation reflected, transmitted or scattered by the pharmaceuticals in the closed vial; matching the measured spectral signature to one of the known spectral signatures; and reporting the identity of the pharmaceutical in the closed vial, wherein the spectral signature is measured using multimodal multiplex sampling spectroscopy.
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20. A method for identifying pharmaceuticals in a closed vial comprising:
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maintaining a database of known spectral signatures corresponding to known pharmaceuticals; placing the closed vial containing the pharmaceuticals in a spectrometer system; directing a beam of electromagnetic radiation at the pharmaceuticals in the closed vial though the side, the bottom or the ton of the closed vial; measuring a spectral signature from the electromagnetic radiation reflected, transmitted or scattered by the pharmaceuticals in the closed vial; matching the measured spectral signature to one of the known spectral signatures; and reporting the identity of the pharmaceutical in the closed vial, wherein the spectral signature is obtained using multimodal multiplex sampling Raman spectroscopy. - View Dependent Claims (21, 22)
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23. A method for identifying pharmaceuticals in a closed vial comprising;
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maintaining a database of known spectral signatures corresponding to known pharmaceuticals; placing the closed vial containing the pharmaceuticals in a spectrometer system; directing a beam of electromagnetic radiation at the pharmaceuticals in the closed vial though the side, the bottom or the top of the closed vial; measuring a spectral signature from the electromagnetic radiation reflected, transmitted or scattered by the pharmaceuticals in the closed vial; matching the measured spectral signature to one of the known spectral signatures; and reporting the identity of the pharmaceutical in the closed vial, wherein the database also contains the weight of the known pharmaceuticals, further comprising calculating the total weight of the prescription vial and the pharmaceuticals, to verify that the vial contains the correct number of pharmaceuticals.
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24. A method for identifying pharmaceuticals in a closed vial comprising:
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maintaining a database of known spectral signatures corresponding to known pharmaceuticals; placing the closed vial containing the pharmaceuticals in a spectrometer system; directing a beam of electromagnetic radiation at the pharmaceuticals in the closed vial though the side, the bottom or the to of the closed vial; measuring a spectral signature from the electromagnetic radiation reflected, transmitted or scattered by the pharmaceuticals in the closed vial; matching the measured spectral signature to one of the known spectral signatures; and reporting the identity of the pharmaceutical in the closed vial, wherein the prescription vial is rotated to ensure that the beam of electromagnetic radiation illuminates a random selection of the pharmaceuticals in the closed vial.
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25. A method for identifying an unknown pharmaceutical in a prescription vial comprising:
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creating, naming, and storing a plurality of known pharmaceutical spectral signatures using one or more multimodal multiplex sampling (MMS) spectrometers; measuring the spectral signature of an unknown pharmaceutical using a multimodal multiplex sampling (MMS) spectrometer; comparing the measured spectral signature of the unknown pharmaceutical to at least one of the known spectral signatures; determining if the measured spectral signature of the unknown pharmaceutical matches one of the known spectral signatures; if the measured spectral signature of the unknown pharmaceutical does not match one of the known spectral signatures, reporting that the identity of the unknown pharmaceutical could not be determined; and if the measured spectral signature of the unknown pharmaceutical matches one of the known spectral signatures, reporting the identity of the unknown pharmaceutical. - View Dependent Claims (26, 27, 28, 29)
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Specification