Shunt device and method for treating glaucoma

• US 7,220,238 B2
• Filed: 07/27/2004
• Issued: 05/22/2007
• Est. Priority Date: 04/26/1999
• Status: Expired due to Term

• Current Assignee: Glaukos Corporation
• Original Assignee: GMP Vision Solutions, Inc.
• Inventors: Brown, Reay H., Lynch, Mary G., Ball, Stuart
• Primary Examiner(s): Bianco; Patricia
• Application Number:
  US10/899,687
• Publication Number:
  US 20050038334A1
• Time in Patent Office: 1,029 Days
• Field of Search: 64 8- 10, 642/64, 645/23, 642/84, 642/89, 645/21, 606107-108, 623/4.1, 623/1.11, 623/1.1, 623/1.35
• US Class Current: 604/8
• CPC Class Codes: A61F 2250/0067 Means for introducing or releasing pharmaceutical products into the body
• CPC Class Codes: A61F 9/0017 implantable in, or in contact with, the eye, e.g. ocular inserts
• CPC Class Codes: A61F 9/00781 Apparatus for modifying intraocular pressure, e.g. for glaucoma treatment drainage implants in general A61M27/002
• CPC Class Codes: A61M 2210/0612 Eyes
• CPC Class Codes: A61M 25/0068 Static characteristics of the catheter tip, e.g. shape, atraumatic tip, curved tip or tip structure
• CPC Class Codes: A61M 25/007 Side holes, e.g. their profiles or arrangements; Provisions to keep side holes unblocked

Abstract

The present invention provides a shunt for the flow of aqueous humor from the anterior chamber of the eye to Schlemm'"'"'s canal. The device comprises at least one lumen and optionally has at least one anchor extending from the proximal portion within the anterior chamber to assist in placement and anchoring of the device in the correct anatomic position.

Claims

1. A method of controlling the flow of aqueous humor in a living eye having an anterior chamber, a Schlemm'"'"'s canal, and an episcleral venous system, the method comprising:

introducing into the living eye an indwelling tubular body which leads from the anterior chamber into Schlemm'"'"'s canal to provide an aqueous humor directing channel out of the anterior chamber; and

draining aqueous humor through the tubular body to reduce intraocular pressure in the living eye.

2. The method of claim 1, wherein the flow rate of the aqueous humor is below about 2.5 microliters per minute.

3. The method of claim 1, wherein the flow rate of the aqueous humor is sufficient to maintain eye pressure above 6.0 mmHg.

4. The method of claim 1, wherein aqueous humor is produced by the eye at a rate that is about the same as the flow rate of aqueous humor through the tubular body.

5. The method of claim 1, wherein the flow rate maintains eye pressure between approximately 15 mmHg and 21 mmHg.

6. The method of claim 1, wherein aqueous humor is drained at a sufficient flow rate to reduce build-up of aqueous humor in the anterior chamber without hypotony.

7. The method of claim 6, wherein the flow rate is below about 2.5 microliters per minute.

8. The method of claim 1, wherein the tubular body comprises an arcuate outer surface.

9. The method of claim 1, wherein the tubular body comprises a cylindrical portion.

10. The method of claim 1, wherein the tubular body comprises a metal.

11. The method of claim 1, wherein the tubular body is dimensioned to allow non-linear fluid communication.

12. A method of controlling the flow of aqueous humor in a living eye having an anterior chamber, a Schlemm'"'"'s canal, and an episcleral venous system, the method comprising:

introducing a tubular body between Schlemm'"'"'s canal and the anterior chamber, wherein the tubular body provides a first aqueous humor directing channel from the anterior chamber toward Schlemm'"'"'s canal; and

draining aqueous humor through the tubular body to reduce build-up of aqueous humor in the living eye.

13. The method of claim 12, wherein the tubular body provides a second aqueous humor directing channel from Schlemm'"'"'s canal toward the episcleral venous system.

14. A method of controlling the flow of aqueous humor in a living eye having an anterior chamber, a Schlemm'"'"'s canal, and an episcleral venous system, the method comprising:

placing a substantially hollow device in the living eye leading from Schlemm'"'"'s canal to the anterior chamber of the eye, wherein device provides an elongated aqueous humor directing channel within Schlemm'"'"'s canal to guide the flow of aqueous humor from the anterior chamber toward the episcleral venous system, wherein the outer diameter of the portion of the device placed within Schlemm'"'"'s canal is between about 0.1 mm and 0.5 mm; and

draining aqueous humor along the clongated aqueous humor directing channel to maintain pressure above approximately 6.0 mmHg in the living eye.

15. The method of claim 14, wherein the flow rate maintains eye pressure between approximately 15 mmHg and 21 mmHg.

16. A method of controlling the flow of aqueous humor in a living eye having an anterior chamber, a Schlemm'"'"'s canal, and an episcleral venous system, the method comprising:

introducing a tubular body into Schlemm'"'"'s canal and the anterior chamber to provide a non-linear aqueous humor directing channel from the anterior chamber toward the episcleral venous system; and

draining aqueous humor through the tubular body at a sufficient flow rate to permit intraocular pressure to be reduced in the living eye.

17. The method of claim 16, wherein aqueous humor is drained at a sufficient flow rate to permit the reduction of intraocular pressure to no more than 21 mmHg.

18. The method of claim 16, wherein aqueous humor is drained at a sufficient flow rate to permit the reduction of intraocular pressure to establish a normal intraocular pressure for the eye.

19. The method of claim 16, wherein aqueous humor is drained at a sufficient flow rate to permit the regulation of intraocular pressure to no more than 21 mmHg.

20. The method of claim 16, wherein aqueous humor is drained at a sufficient flow rate to permit the regulation of intraocular pressure to establish a normal intraocular pressure for the eye.

21. A method of controlling the flow of aqueous humor in a living eye having an anterior chamber, a Schlemm'"'"'s canal, and an episcleral venous system, the method comprising:

providing a tubular body in Schlemm'"'"'s canal comprising an elongated aqueous humor directing channel, wherein the outer diameter of the tubular body in Schlemm'"'"'s canal is between about 0.1 mm and 0.5 mm, and the aqueous humor directing channel guides the flow of aqueous humor from the anterior chamber toward the episcleral venous system; and

draining aqueous humor along the elongated aqueous humor directing channel at a sufficient flow rate to maintain pressure above approximately 6.0 mmHg in the living eye.

22. The method of claim 21, wherein the tubular body comprises a metal.

23. The method of claim 21, wherein the tubular body is non-linear.