Array assay devices and methods of using the same
First Claim
1. An array assay device comprising:
- (a) a housing comprising;
(i) a base comprising an interior surface and an exterior surface and is dimensioned to hold a substrate carrying at least one array;
(ii) a cover comprising an interior surface and an exterior surface; and
(iii) a snap-fit attachment for holding said cover and said base together to enclose a space between said interior surface of said cover and said interior surface of said base, wherein the cover is shaped and dimensioned to cover a substrate and an array assay area element held by the base when the base and the cover are snap-fit together; and
(b) an array assay area element comprising a sealing element and at least one access port, where said array assay area element is dimensioned to cover a substrate comprising a plurality of arrays such that when the base and the cover are snap-fit together, the assay area element is positioned over the substrate and plurality of arrays to provide a substantially vapor and fluid tight assay area around each array of said plurality; and
(c) an array substrate comprising a plurality of arrays of addressable probe molecules,wherein said snap-fit is configured to apply a force to said array substrate and array assay element to hold said substrate and array assay area element together to provide a vapor and fluid tight assay area around each array of said plurality.
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Accused Products
Abstract
Array assay devices and methods for using the same in array based assays are provided. The subject devices are characterized by having a base dimensioned to hold a substrate having at least one array, a cover dimensioned to cover the substrate and a snap-fit for holding the cover and the base together to enclose a space between the base and the cover. The subject invention also includes methods for performing an array assay. In the subject methods, a subject device is provided and a substrate having at least one array is positioned on the base. The snap-fit is engaged to hold the cover and the base together to enclose a space between the base and the cover. Next, a sample is contacted with the at least one array and an array assay is performed. The subject invention also includes kits which include the subject devices.
68 Citations
20 Claims
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1. An array assay device comprising:
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(a) a housing comprising; (i) a base comprising an interior surface and an exterior surface and is dimensioned to hold a substrate carrying at least one array; (ii) a cover comprising an interior surface and an exterior surface; and (iii) a snap-fit attachment for holding said cover and said base together to enclose a space between said interior surface of said cover and said interior surface of said base, wherein the cover is shaped and dimensioned to cover a substrate and an array assay area element held by the base when the base and the cover are snap-fit together; and (b) an array assay area element comprising a sealing element and at least one access port, where said array assay area element is dimensioned to cover a substrate comprising a plurality of arrays such that when the base and the cover are snap-fit together, the assay area element is positioned over the substrate and plurality of arrays to provide a substantially vapor and fluid tight assay area around each array of said plurality; and (c) an array substrate comprising a plurality of arrays of addressable probe molecules, wherein said snap-fit is configured to apply a force to said array substrate and array assay element to hold said substrate and array assay area element together to provide a vapor and fluid tight assay area around each array of said plurality. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18)
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19. An array assay device comprising:
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(a) an array substrate comprising at least one array of addressable probe molecules; (b) an array assay area element having at least one access port and a sealing element around the array assay area, wherein said array assay area element is dimensioned to provide a substantially vapor and fluid tight assay area around each of a plurality of arrays of said substrate when positioned over said substrate; and (c) a housing comprising; (i) a base comprising an interior surface and an exterior surface; (ii) a cover comprising an interior surface and an exterior surface; and (iii) a snap-fit attachment for holding said cover and said base together to enclose a space between said interior surface of said cover and said interior surface of said base that is dimensioned to hold the substrate and array assay area element by a force that is sufficient to provide a vapor and fluid tight assay area around said at least one array; wherein said array assay substrate and array assay area element are not attached to said cover or base. - View Dependent Claims (20)
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Specification