Dermacentor variabilis GABA-gated chloride channels

• US 7,220,832 B2
• Filed: 03/28/2001
• Issued: 05/22/2007
• Est. Priority Date: 03/31/2000
• Status: Active Grant

• Current Assignee: Merial Limited (C.H. Boehringer Sohn AG & Co. KG)
• Original Assignee: Merck & Co., Inc.
• Inventors: Cully, Doris F., Ludmerer, Steve W., Zheng, Yingcong
• Primary Examiner(s): Pak; Michael
• Application Number:
  US10/239,956
• Publication Number:
  US 20030208041A1
• Time in Patent Office: 2,246 Days
• Field of Search: None
• US Class Current: 530/350
• CPC Class Codes: A61K 38/00 Medicinal preparations containing peptides peptides containing beta-lactam rings A61K31/00; cyclic dipeptides not having in their molecule any other peptide link than those which form their ring, e.g. piperazine-2,5-diones, A61K31/00; ergot alkaloids of the cyclic peptide type A61K31/48; containing macromolecular compounds having statistically distributed amino acid units A61K31/74; medicinal preparations containing antigens or antibodies A61K39/00; medicinal preparations characterised by the non-active ingredients, e.g. peptides as drug carriers, A61K47/00
• CPC Class Codes: A61P 33/14 Ectoparasiticides, e.g. scabicides
• CPC Class Codes: C07K 14/43527 from ticks
• CPC Class Codes: C07K 7/06 having 5 to 11 amino acids
• CPC Class Codes: C07K 7/08 having 12 to 20 amino acids gastrins C07K14/595; somatostatins C07K14/655; melanotropins C07K14/68

Abstract

The present invention features Dermacentor variabilis GABA-gated chloride channel polypeptides and nucleic acids, and uses of such polypeptides and nucleic acids. D. variabilis is a widely distributed tick associated with different diseases. A preferred use of the present invention is to obtain compounds for preventing or treating a tick infestation.

Claims

1. A purified polypeptide, wherein said polypeptide comprises an amino acid sequence selected from the group consisting of SEQ. ID. NO. 1, SEQ. ID. NO. 2, and SEQ. ID. NO. 3.

2. The polypeptide of claim 1, wherein said polypeptide consists of an amino acid sequence selected from the group consisting of SEQ. ID. NO. 1, SEQ. ID. NO. 2, and SEQ. ID. NO. 3.