Diagnosis of the presence of cochlear hydrops using observed auditory brainstem responses
First Claim
1. A procedure for diagnosing cochlear hydrops comprising:
- recording a patient'"'"'s auditory brainstem response to an unmasked broadband click stimulus;
recording a plurality of masked auditory brainstem responses, wherein each of the masked auditory brainstem responses is responsive to a broadband click stimulus that is masked by high-pass noise with a high-pass cut-off at a respective one of a plurality of cut-off frequencies;
calculating a latency difference between a wave V peak of the unmasked response and a wave V peak of a masked response having a low cut-off frequency;
diagnosing the likely presence of cochlear hydrops if the latency difference is less than a threshold value based on results in an appropriate control population.
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Abstract
A procedure for diagnosing cochlear hydrops is based, in part, on an analysis of the patient'"'"'s auditory brainstem response (ABR) to stimuli. The patient'"'"'s ABR to a broadband click stimulus is recorded. A plurality of masked ABR'"'"'s are also recorded, wherein the stimulus is masked by high-pass noise with a plurality of high-pass cut-off frequencies. The latency difference between the wave V component in the unmasked click alone response and the undermasked wave V component of a low cut-off frequency high-pass response is then calculated. If an undermasked component is not present, the normal wave V component is used. The measured latency difference is combined with another measure, such as the wave V amplitude ratio. A distribution of the combined measure is then plotted for the population and a threshold established for diagnosing cochlear hydrops. Alternatively, the joint distribution of the individual measures may be used in situations where the individual measures are known to be independent.
44 Citations
14 Claims
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1. A procedure for diagnosing cochlear hydrops comprising:
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recording a patient'"'"'s auditory brainstem response to an unmasked broadband click stimulus; recording a plurality of masked auditory brainstem responses, wherein each of the masked auditory brainstem responses is responsive to a broadband click stimulus that is masked by high-pass noise with a high-pass cut-off at a respective one of a plurality of cut-off frequencies; calculating a latency difference between a wave V peak of the unmasked response and a wave V peak of a masked response having a low cut-off frequency; diagnosing the likely presence of cochlear hydrops if the latency difference is less than a threshold value based on results in an appropriate control population. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14)
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Specification