Device and method for detecting the coagulation functions of global, especially primary hemostasis
First Claim
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1. A device for examining properties of global, including primary, hemostasis functions in whole blood or platelet-rich plasma, comprising:
- a storage chamber for the blood or plasma to be examined;
a reaction device having at least one reaction opening via which blood or plasma to be examined is transported;
a conveyor device for transport of the blood or plasma through the reaction device; and
a collection chamber for collecting the blood or plasma transported through the reaction device, wherein the at least one reaction opening is formed in a partition made of a nonporous material which is provided with a bioactive coating on at least one of two partition surfaces thereof and/or on the respective boundary surface of the reaction opening.
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Abstract
A method and a device are provided for examining the properties of the global, in particular the primary, hemostasis functions in whole blood or platelet-rich plasma. A volumetric blood flow is preferably adjusted, depending on the measured pressure of the volumetric flow, so that the shear rate or the shear force, whose action in the reaction opening causes blood components, in particular thrombocytes, to deposit, follows a predetermined characteristic curve and in particular is held constant.
43 Citations
8 Claims
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1. A device for examining properties of global, including primary, hemostasis functions in whole blood or platelet-rich plasma, comprising:
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a storage chamber for the blood or plasma to be examined; a reaction device having at least one reaction opening via which blood or plasma to be examined is transported; a conveyor device for transport of the blood or plasma through the reaction device; and a collection chamber for collecting the blood or plasma transported through the reaction device, wherein the at least one reaction opening is formed in a partition made of a nonporous material which is provided with a bioactive coating on at least one of two partition surfaces thereof and/or on the respective boundary surface of the reaction opening. - View Dependent Claims (2, 3, 4)
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5. A method for detecting global hemostasis function, including primary hemostasis, comprising;
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conveying blood to be examined from a storage chamber under predetermined flow conditions through at least one reaction opening of a reaction device, when blood components are deposited on the reaction surfaces under the action of shear forces in the at least one reaction opening; measuring a variable pressure; wherein, before the variable pressure measurement is begun, blood viscosity is determined; adjusting the volumetric flow of the blood conveyed through the reaction device depending on the respective measured pressure such that the shear rate or the shear force which acts in at least one reaction opening follows a predetermined characteristic curve for the shear rate or shear force; wherein said characteristic curve is selected depending on the diagnosis to be made. - View Dependent Claims (6, 7, 8)
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Specification