Production process for polymeric micelle charged therein with drug and polymeric micelle composition

• US 7,223,419 B2
• Filed: 09/22/2003
• Issued: 05/29/2007
• Est. Priority Date: 02/09/2000
• Status: Expired due to Term

• Current Assignee: NanoCarrier Co., Ltd.
• Original Assignee: NanoCarrier Co., Ltd.
• Inventors: Yokoyama, Masayuki, Ogawa, Yasuaki, Honzawa, Eiichi
• Primary Examiner(s): Hartley; Michael G.
• Assistant Examiner(s): ROGERS, JAMES WILLIAM
• Application Number:
  US10/666,384
• Publication Number:
  US 20040056372A1
• Time in Patent Office: 1,345 Days
• Field of Search: None
• US Class Current: 424/489
• CPC Class Codes: A61K 9/1075 Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers A61K9/0026 takes precedence
• CPC Class Codes: A61P 29/00 Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
• CPC Class Codes: A61P 31/04 Antibacterial agents
• CPC Class Codes: A61P 31/10 Antimycotics
• CPC Class Codes: A61P 35/00 Antineoplastic agents

Abstract

Provided are a production process for a polymeric micelle which is stable and has a high drug content and a composition containing such polymeric micelle. Disclosed are a production process for a polymeric micelle, comprising the steps of dissolving a drug and a specific copolymer in a water non-miscible organic solvent to prepare a solution, mixing the resulting solution with water to form an O/W type emulsion and then slowly volatilizing the organic solvent from the solution, and a polymeric micelle composition charged therein with a water-scarcely soluble drug, which can be obtained by the above production process.

Claims

1. A process for the production of a polymeric micelle charged therein with a water-scarcely soluble drug, comprising the steps of:

(A) dissolving a water-scarcely soluble drug and a block copolymer having a hydrophilic segment and a hydrophobic segment in a water non-miscible organic solvent to prepare an organic solution,

wherein the block copolymer is represented by the following Formula (I) or (II)