Diffraction-based diagnostic devices
First Claim
Patent Images
1. A diffraction-based biosensor, comprising:
- a substrate member;
a receptive material layer generally uniformly covering a side of said substrate member, said receptive material being specific for an analyte of interest; and
a pattern of active and inactive areas of said receptive material defined on said layer, said active and inactive areas formed by a masking process wherein a mask is placed over said substrate member such that areas exposed by said mask define said pattern of inactive areas of said receptive material and areas protected by said mask define said pattern of active areas of said receptive material, wherein the size and periodicity of said actives areas are selected to produce a visibly detectable diffraction pattern upon exposure to a medium containing the analyte and irradiation with light, the periodicity being at least greater than 10 μ
m to produce the visible diffraction.
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Accused Products
Abstract
A biosensor includes a substrate with a layer of receptive material disposed thereon. The receptive material is specific for an analyte of interest. A pattern of active and deactivated areas of the receptive material are defined in the receptive material layer by a masking process.
197 Citations
25 Claims
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1. A diffraction-based biosensor, comprising:
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a substrate member; a receptive material layer generally uniformly covering a side of said substrate member, said receptive material being specific for an analyte of interest; and a pattern of active and inactive areas of said receptive material defined on said layer, said active and inactive areas formed by a masking process wherein a mask is placed over said substrate member such that areas exposed by said mask define said pattern of inactive areas of said receptive material and areas protected by said mask define said pattern of active areas of said receptive material, wherein the size and periodicity of said actives areas are selected to produce a visibly detectable diffraction pattern upon exposure to a medium containing the analyte and irradiation with light, the periodicity being at least greater than 10 μ
m to produce the visible diffraction. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12)
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13. A method of making a diffraction-based biosensor, comprising the steps of:
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forming a receptive material layer generally uniformly over a surface of a substrate member, said receptive material being specific for an analyte of interest; placing a mask over the substrate member, the mask having a configuration so as to cover at least one underlying area of the substrate member while exposing at least one adjacent area; irradiating the substrate member and mask combination with light to deactivate the receptive material in areas exposed by the mask, thereby forming a pattern of active and inactive areas of the receptive material, the inactive areas corresponding to the areas exposed by the mask and the active areas corresponding to the areas underlying the mask; and removing the mask from the substrate member; wherein the size and periodicity of said actives areas are selected to produce a visibly detectable diffraction pattern upon exposure to a medium containing the analyte and irradiation, the periodicity being at least greater than 10 μ
m to produce the visible diffraction. - View Dependent Claims (14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25)
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Specification