Nucleic acid-binding polymers
First Claim
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1. A water soluble nucleic acid binding polymer comprising a backbone polymer and a nucleic acid binding agent, wherein the backbone polymer is not a polynucleotide, and wherein said nucleic acid binding agent is an intercalating agent or a minor groove binder.
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Abstract
The present invention relates to a nucleic acid binding polymer which has affinity for nucleic acid molecules such as DNA, RNA, or hybrids thereof. The polymer is comprised of a nucleic acid binding backbone linked to a nucleic acid binding agent, preferably by a linking moiety. The polymer can be used to isolate and purify nucleic acid molecules from a variety of sample types including but not limited to clinical and environmental.
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Citations
20 Claims
- 1. A water soluble nucleic acid binding polymer comprising a backbone polymer and a nucleic acid binding agent, wherein the backbone polymer is not a polynucleotide, and wherein said nucleic acid binding agent is an intercalating agent or a minor groove binder.
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6. A water soluble nucleic acid binding polymer comprising a backbone polymer and a nucleic acid binding agent, wherein said backbone polymer is linear polyacrylamide, and wherein said nucleic acid binding agent is an intercalating agent or a minor groove binder.
- 14. A water soluble nucleic acid binding polymer comprising a backbone polymer and a nucleic acid binding agent, wherein said backbone polymer comprises monomers which include acrylic acid, acrylamide, an acrylate, a glycol, an amino acid, or a substituted styrene, and wherein said nucleic acid binding agent is an intercalating agent or a minor groove binder.
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17. A nucleic acid binding polymer comprising:
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a backbone polymer comprising polyacrylamide; and a nucleic acid binding agent linked to the backbone polymer, wherein the nucleic acid binding agent binds a double-stranded segment of a nucleic acid preferentially to a single-stranded segment of a nucleic acid, and wherein said nucleic acid binding agent is an intercalating agent or a minor groove binder. - View Dependent Claims (18, 19, 20)
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Specification