System and method for confocal imaging within dermal tissue
First Claim
1. A system for dermatological examination of the skin tissue of a patient comprising:
- a plate;
means for maintaining an area of the skin tissue under stress by application of force against said plate, in which said maintaining means comprises a member extending from said plate; and
an imaging head, coupled to said maintaining means, capable of producing one or more images representing optically formed sections of said stressed skin tissue from light returned through said plate from focused light under the surface of said skin tissue to provide therewith an integrated assembly in which said stress applied to said tissue stabilizes said skin tissue with respect to said imaging head, wherein said imaging head comprises at least an objective lens for focusing the light under the surface of said skin tissue and collecting the returned light through said plate, and at least one actuator capable of moving said objective lens to change location of said focusing in said tissue.
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Accused Products
Abstract
An improved system for confocal imaging within dermal tissue of a patient is provided which minimizes instability in confocal images by reducing the relative motion of the tissue with respect to the confocal imaging optics of the system. The system includes a mechanism for maintaining an area of skin tissue under stress by application of force at the edges of the area, and an imaging head coupled to this mechanism for imaging the stressed skin. The mechanism includes a mechanical structure, such as a platen, brace, or attachment, which both supports the imaging head of the system and applies stress to a limited surface area of the tissue to minimize skin motion during confocal imaging.
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Citations
35 Claims
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1. A system for dermatological examination of the skin tissue of a patient comprising:
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a plate; means for maintaining an area of the skin tissue under stress by application of force against said plate, in which said maintaining means comprises a member extending from said plate; and an imaging head, coupled to said maintaining means, capable of producing one or more images representing optically formed sections of said stressed skin tissue from light returned through said plate from focused light under the surface of said skin tissue to provide therewith an integrated assembly in which said stress applied to said tissue stabilizes said skin tissue with respect to said imaging head, wherein said imaging head comprises at least an objective lens for focusing the light under the surface of said skin tissue and collecting the returned light through said plate, and at least one actuator capable of moving said objective lens to change location of said focusing in said tissue. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12)
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13. A system for dermatological examination of the skin tissue of a patient comprising:
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means for maintaining an area of the skin tissue under stress by application of force, and an imaging head, coupled to said maintaining means, capable of imaging a section of said stressed skin tissue to provide therewith an integrated assembly, wherein said maintaining means further comprises; a platen which is positionable with respect to said patient, said platen having an orifice, and said imaging head being coupled to said platen and positioned for imaging through said orifice; first means for moving said platen from an up position in which said platen is spaced from said patient to a down position onto the surface of said skin tissue of the patient, whereby in said down position the force of said platen provides said stressed skin tissue within said orifice; and second means coupled to said platen for moving said platen with respect to said patient and temporarily fixing the position of said platen so that said skin tissue to be imaged is located within said orifice when said first means moves said platen to said down position, wherein said second means further comprises; a table having a surface supporting said patient and two opposing sides spaced apart from each other on opposite sides of said patient; two first rails, each of said first rails being parallel to each other and located upon a different one of said opposing sides; two second rails orthogonal to said first rails which are parallel to each other and movable together along said first rails; a carriage supporting said platen which is movable along said second rails; means for locking said second rails at a position with respect to said first rails; and means for locking said carriage at a position with respect to said second rails. - View Dependent Claims (14)
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15. A system for dermatological examination of the skin tissue of a patient comprising:
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means for maintaining an area of the skin tissue under stress by application of force, and an imaging head, coupled to said maintaining means, capable of imaging a section of said stressed skin tissue to provide therewith an integrated assembly, wherein said maintaining means further comprises; a platen which is positionable with respect to said patient, said platen having an orifice, and said imaging bead being coupled to said platen and positioned for imaging through said orifice; first means for moving said platen from an up position in which said platen is spaced from said patient to a down position onto the surface of said skin tissue of the patient, whereby in said down position the force of said platen provides said stressed skin tissue within said orifice; and means coupled to said imaging head and said platen for translating said imaging head with respect to said orifice of said platen, wherein said platen further comprises a recording media, and said translating mean further comprises a translation stage and a marker coupled to said translation stage which is positioned over said media to record the motion of said translating stage as it moves said imaging head over said stressed tissue within said orifice.
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16. An apparatus for stabilizing the skin tissue of a patient to an imaging head comprising:
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a platen having an orifice; first means for moving said platen from an up position in which said platen is spaced from said patient to a down position onto the surface of said skin tissue of the patient; and second means for moving said platen over the patient and temporarily fixing the position of the platen with respect to said patient wherein the skin tissue to be imaged via said orifice by said imaging head is stabilized when said platen is in a down position, wherein said second means further comprises; a table having a surface supporting said patient and two opposing sides spaced apart from each other on opposite sides of said patient; two first rails, each of said first rails being parallel to each other and located upon a different one of said opposing sides; two second rails orthogonal to said first rails which are parallel to each other and movable together along said first rails; a carriage supporting said platen which is movable along said second rails; means for locking said second rails at a position with respect to said first rails; and means for locking said carriage at a position with respect to said second rails. - View Dependent Claims (17, 18)
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19. A system for examining tissue comprising:
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a plate; means for maintaining an area of the tissue under stress by application of force of said plate upon said tissue, in which said maintaining means comprises a member extending from said plate; and an imaging head, coupled to said maintaining means, capable of imaging said stressed tissue through said plate from light returned from a scanned focal spot through said tissue to provide an image of a section, wherein said imaging head comprises at least an objective lens for focusing the light under the surface of said skin tissue and collecting the returned light through said plate, and at least one actuator capable of moving said objective lens to change location of said focusing in said tissue. - View Dependent Claims (20, 21, 22)
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23. A method for examination of tissue comprising the steps of:
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providing a platen having an opening with a plate; maintaining an area of the tissue under stress by application of said platen upon said tissue; and optically forming one or more images of a section of said stressed tissue via an objective lens through said opening of said platen from light returned from focused light under the surface of said skin tissue in which said stress applied to said tissue promotes stabilization of said tissue with respect to images produced by said imaging step; and positioning said objective lens within a housing having said objective lens to adjust at least the depth of said images of said sections in said skin tissue. - View Dependent Claims (24)
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25. An apparatus for dermatological examination of the tissue of a patient comprising:
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a plate; means for maintaining an area of the skin tissue under stress by application of force against said plate, in which said maintaining means comprises a member extending from said plate; and means for imaging said tissue through said plate, said imaging means being coupled to said maintaining means and capable of producing images representing optically formed sections through different planes of said stressed tissue in which said stress applied to said tissue stabilizes said tissue with respect to said imaging head, in which said imaging means comprises optics and said maintaining means limits view of said tissue by said optics, wherein said optics are movable to focus and collect light from different locations of said tissue in said limited view provided by said maintaining means. - View Dependent Claims (26, 27, 28)
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29. A system for examination of tissue of a patient comprising:
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a member having a surface, said member being positionable for compressing and maintaining an area of the tissue under stress by application of force against said surface, in which said member has an opening; a material window; and an imaging head, coupled to said member, capable of producing one or more images representing optically formed sections at desired orientations and depths within said stressed tissue from light returned through said opening and said material window from focused light under the surface of said tissue, in which said stress applied to said tissue stabilizes said tissue, wherein said imaging head comprises optics for focusing the light under the surface of said skin tissue through said opening and said window, and collecting the returned light through opening and said window, and said optics are movable to select at least the depth of said images of said sections in said skin tissue. - View Dependent Claims (30)
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31. A system for examination of tissue of a patient comprising:
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a member positionable against tissue for compressing and maintaining an area of the tissue under stress by application of a non-suctioning force, in which said member has an opening; a material window; and an imaging head, coupled to said member, capable of producing one or more images of optically formed sections within said stressed tissue via said opening and said material window, in which said stress applied to said tissue stabilizes said tissue. - View Dependent Claims (32)
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- 33. An apparatus for stabilizing the skin tissue of a patient to an imaging head comprising a carriage having a platen with an orifice positionable over the skin tissue of a patient, said carriage being positionable along a first path with respect to said skin tissue, and positionable along a second path with respect to said skin tissue, in which said first and second paths are orthogonal to each other, and when said carriage is positioned along said first and second paths said platen is positionable onto the patient to locate the orifice with respect to the skin tissue to be imaged.
Specification