Implantable medical device with nerve signal sensing

• US 7,225,016 B1
• Filed: 06/16/2004
• Issued: 05/29/2007
• Est. Priority Date: 06/16/2004
• Status: Expired due to Fees

• Current Assignee: Pacesetter Incorporated (Abbott Laboratories)
• Original Assignee: Pacesetter Incorporated (Abbott Laboratories)
• Inventors: Koh, Steve
• Primary Examiner(s): Pezzuto; Robert
• Assistant Examiner(s): Johnson; Shevon
• Application Number:
  US10/870,367
• Time in Patent Office: 1,077 Days
• Field of Search: 607 2- 6, 607/42, 607/48, 607/118, 607/62, 600/544, 600/546, 600/554, 600/557
• US Class Current: 607/2
• CPC Class Codes: A61B 5/24 Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
• CPC Class Codes: A61B 5/361 Detecting fibrillation
• CPC Class Codes: A61B 5/363 Detecting tachycardia or bradycardia
• CPC Class Codes: A61B 5/388 Nerve conduction study, e.g. detecting action potential of peripheral nerves
• CPC Class Codes: A61B 5/4041 Evaluating nerves condition
• CPC Class Codes: A61N 1/0551 Spinal or peripheral nerve electrodes
• CPC Class Codes: A61N 1/0556 Cuff electrodes
• CPC Class Codes: A61N 1/3601 of respiratory organs
• CPC Class Codes: A61N 1/3605 Implantable neurostimulators for stimulating central or peripheral nerve system
• CPC Class Codes: A61N 1/36114 Cardiac control, e.g. by vagal stimulation stimulating the heart A61N1/362
• CPC Class Codes: A61N 1/365 controlled by a physiological parameter, e.g. heart potential evoked response A61N1/371
• CPC Class Codes: A61N 1/39622 Pacing therapy

Abstract

An implantable medical device which has a sensor that provides a waveform to an energy accumulator, such as a capacitor. The waveform is representative of electrical activity from a nerve. The implantable medical device further includes a threshold detector which provides a discrete output signal when the energy in the signal energy accumulator exceeds a threshold. The signal energy accumulator can be periodically discharged and then recharged during the time period that electrical activity is being sensed from the nerve thereby generating a number of discrete output signals each time the recharged energy accumulator exceeds the threshold. The frequency and number of pulsed outputs is indicative of the sensed electrical activity.

Claims

1. An implantable medical device adapted to be implanted within a patient, the device comprising:

a nerve sensing system that senses the duration and magnitude of an electrical signal from a nerve of the patient and accumulates energy therefrom, wherein the nerve sensing system is programmed to;

i) compare the accumulated energy to a threshold;

ii) when the accumulated energy exceeds the threshold, provide an output signal;

iii) when the accumulated energy exceeds the threshold, partially dissipate the accumulated energy; and

iv) repeat steps i)–

iii) as the electrical signal is sensed from the nerve.

2. The device of claim 1, wherein the nerve sensing system includes a nerve sensing component that couples to the nerve such that electrical activity from the nerve is provided to the nerve sensing system.

3. The device of claim 2, wherein the nerve sensing component comprises an electrode assembly that is adapted to be positioned about the nerve so as to be electrically coupled therewith.

4. The device of claim 3, wherein the electrode assembly is in electrical contact with the surface of the nerve.

5. The device of claim 1, wherein the nerve sensing system accumulates nerve signal energy in a capacitor.

6. The device of claim 1, wherein the nerve sensing system further comprises a threshold detector and a one-shot device in communication with the threshold detector such that the one-shot device provides a pulsed output signal when the accumulated energy exceeds the threshold.

7. The device of claim 6, wherein the threshold detector comprises a comparator.

8. The device of claim 6, wherein the threshold is adjustable to provide adjustable nerve sensing resolution by varying the characteristics of the pulsed output.

9. The device of claim 6, further comprising a gated dissipation component wherein the gated dissipation component partially dissipates the accumulated energy when the one-shot device provides the output signal such that the nerve signal energy is successively accumulated and discharged while the nerve sensing system is sensing the nerve signal to thereby provide a plurality of output signals indicative of the magnitude and duration of the nerve signal.

10. The device of claim 9, wherein the gated dissipation component comprises a transistor coupled to a capacitor so as to provide a gated path to ground and wherein the gate of the transistor receives a signal to enable the transistor when the one-shot device provides an output signal.

11. The device of claim 1, further comprising a controller receiving the output signals so as to perform at least one of storage and analysis of the output signals.

12. The device of claim 11, further comprising:

a stimulation pulse generator; and

at least one lead with at least one stimulation electrode operably connected to the stimulation pulse generator wherein the controller evaluates the output signals and, upon determination that the output signals indicate delivery of therapy, induces the stimulation pulse generator and at least one lead with at least one stimulation electrode to deliver an appropriate stimulation to the patient.

13. The device of claim 12, wherein the nerve sensing system is arranged to sense phrenic nerve activity and wherein the controller evaluates the output signals for indications of central sleep apnea and, upon determination that an episode of central sleep apnea has occurred, induces the stimulation pulse generator and at least one lead with at least one electrode to provide appropriate stimulation to the patient'"'"'s diaphragm.

14. The device of claim 13, wherein the appropriate stimulation is provided to the patient'"'"'s diaphragm via application of stimulation to a phrenic nerve.

15. An implantable stimulation device adapted to be implanted within a patient so as to provide therapeutic stimulation to a patient, the device comprising:

means for delivering therapeutic electrical stimulation to the patient;

means for sensing and storing energy from activity of a selected nerve of the patient'"'"'s body;

means for consecutively partially dissipating the energy stored by the means for sensing and storing wherein the means for dissipating provides an output signal indicative of the nerve activity; and

means for controlling delivery of therapeutic electrical stimulation to the patient, wherein the means for control uses the output signal to adjust the delivery of the therapeutic electrical stimulation to the patient.

16. The device of claim 15, wherein the means for sensing and storing includes an electrode assembly that is coupled to the nerve and a signal energy accumulator that receives energy from the electrode assembly so as to accumulate energy at a rate corresponding to the magnitude and duration of the electrical signal from the nerve.

17. The device of claim 15, wherein the means for dissipating provides the output signal as a series of pulses wherein the interval between output pulses corresponds to the magnitude of the nerve activity.

18. The device of claim 15, wherein the means for control monitors for indications of central sleep apnea (CSA) and, upon indication of an episode of CSA, induces the means for delivering stimulation to deliver an appropriate stimulation.

19. The device of claim 18, wherein the means for delivering stimulation comprises an electrode coupled to a phrenic nerve and wherein the appropriate stimulation comprises electrical stimulations applied to the phrenic nerve.

20. The device of claim 15, wherein the means for delivering stimulation and the means for sensing and storing commonly comprise an electrode assembly configured to both sense from and stimulate the nerve.