Sensors having protective eluting coating and method therefor

• US 7,225,024 B2
• Filed: 09/30/2003
• Issued: 05/29/2007
• Est. Priority Date: 09/30/2003
• Status: Expired due to Fees

• Current Assignee: Cardiac Pacemakers Incorporated (Boston Scientific Corporation)
• Original Assignee: Cardiac Pacemakers Incorporated (Boston Scientific Corporation)
• Inventors: Zhu, Qingsheng, Heil, Ronald W. Jr., Jain, Mudit
• Primary Examiner(s): WINAKUR, ERIC FRANK
• Application Number:
  US10/677,144
• Publication Number:
  US 20050070768A1
• Time in Patent Office: 1,337 Days
• Field of Search: 600/309, 600/310, 600/316, 600/345, 600/347, 600/365, 600/322, 600/323, 600/324, 600/339, 600/341, 600/342, 607/50, 607/17, 607/18, 607/22, 623/1.42, 623/1.43
• US Class Current: 607/22
• CPC Class Codes: A61B 5/14532 for measuring glucose, e.g. by tissue impedance measurement
• CPC Class Codes: A61B 5/14546 for measuring analytes not otherwise provided for, e.g. ions, cytochromes
• CPC Class Codes: A61N 1/0568 with drug delivery

Abstract

A cardiac management implantable device that has an intravascular device body, and one or more chemical sensors coupled with the intravascular device body. A drug eluting substance is disposed at a location including at least one of on, directly adjacent, or near the one or more chemical sensors, where the drug eluting substance prevents fibrotic growth on the one or more chemical sensors.

Claims

1. An apparatus comprising:

an implantable device including at least one of a lead or a cardiac rhythm management device, the implantable device having a device body including at least one cavity therein;

one or more chemical sensors coupled with the device body adjacent or near the at least one cavity; and

a drug eluting substance disposed within the at least one cavity, the drug eluting substance preventing fibrotic growth on the one or more chemical sensors.

2. The apparatus as recited in claim 1, wherein the drug eluting substance includes a drug mixed with a polymeric binding.

3. The apparatus as recited in claim 1, wherein the at least one cavity partially or completely surrounds an outer perimeter of the one or more chemical sensors, and the drug eluting substance is disposed around the outer perimeter of the one or more chemical sensors.

4. The apparatus as recited in claim 1, wherein the drug eluting substance includes a drug eluting matrix that elutes one or more drugs over time.

5. The apparatus as recited in claim 1, wherein the drug eluting substance is a drug esterified drug.

6. The apparatus as recited in claim 1, wherein the drug eluting substance includes a drug mixed with polymeric binders.

7. The apparatus as recited in claim 1, wherein the implantable device includes the lead, the lead adapted to assist in conducting one or more electrical signals between the cardiac rhythm management device and a heart.

8. The apparatus as recited in claim 1, wherein the implantable device includes the cardiac rhythm management device, the cardiac rhythm management device electrically couplable via the lead to a heart for sensing or stimulation thereof.

9. The apparatus as recited in claim 1, wherein the cavity includes a ring shape, the ring shape completing encircling a perimeter of the device body.

10. The apparatus as recited in claim 1, wherein the one or more chemical sensors are disposed within a recess of the device body, and the at least one cavity is tunneled into a wall of the recess.

11. The apparatus as recited in claim 10, wherein the at least one cavity is tunneled into the wall of the recess at a location above a portion of the one or more chemical sensors.

12. The apparatus as recited in claim 10, wherein the at least one cavity includes a plurality of cavities disposed in an annular ring that forms the wall of the recess.

13. The apparatus as recited in claim 1, wherein the drug eluting substance comprises a preformed shape that fits within the at least one cavity.

14. The apparatus as recited in claim 1, wherein the drug eluting substance is malleable within the at least one cavity.

15. An apparatus comprising:

an implantable device including a lead adapted to assist in conducting one or more electrical signals to and from a heart, the lead having an intravascular device body including a cavity therein;

one or more blood monitoring sensors coupled with the intravascular device body;

a drug eluting substance disposed within the cavity, the drug eluting substance including a pre-compressed drug substance shaped to fit within the cavity to prevent fibrotic growth on the one or more blood monitoring sensors; and

wherein the intravascular body extends from a proximal portion to a distal portion.

16. The apparatus as recited in claim 15, wherein the one or more blood monitoring sensors comprise a glucose sensor.

17. The apparatus as recited in claim 15, wherein the one or more blood monitoring sensors monitor one or more of bicarbonate, blood urea nitrogen (BUN), brain naturetic peptide (BNP), calcium, chloride, osmolarity, potassium, renin, or sodium.

18. The apparatus as recited in claim 15, wherein the pre-compressed drug substance includes a drug compressed with a starch.

19. The apparatus as recited in claim 15, wherein the one or more blood monitoring sensors are coupled to the distal portion of the intravascular device body.

20. The apparatus as recited in claim 19, wherein the one or more blood monitoring sensors are adapted to be transvenously guided into a right atrium of a heart, through a coronary sinus and into a great cardiac vein.

21. The apparatus as recited in claim 19, wherein the one or more blood monitoring sensors are adapted to be inserted into at least one of a right atrium or a right ventricle of a heart.

22. The apparatus as recited in claim 19, wherein the one or more blood monitoring sensors are adapted to be transarterially inserted into at least one of a left atrium or a left ventricle of a heart.

23. The apparatus as recited in claim 15, wherein the cavity includes a ring shape, the ring shape completely encircling a perimeter of the intravascular device body.

24. An apparatus comprising:

an implantable device including at least one of a lead adapted to assist in conducting electrical signals to and from a heart or a cardiac rhythm management device electrically couplable to the heart for sensing or stimulation thereof, the implantable device having a device body including a cavity therein;

means for sensing a chemical substance coupled with the device body; and

means for chemically preventing fibrotic growth on the means for sensing a chemical substance, the means for chemically preventing fibrotic growth including a pre-compressed drug substance shaped to fit within the cavity.

25. The apparatus as recited in claim 24, wherein the pre-compressed drug substance includes a drug compressed with a starch.

26. The apparatus as recited in claim 24, wherein the means for sensing a chemical substance is a glucose sensor.

27. The apparatus as recited in claim 24, wherein the device body includes a recess therein, and the means for sensing a chemical substance is disposed, at least in part, within the recess.

28. The apparatus as recited in claim 24, wherein the cavity encircles at least a portion of a perimeter of the device body.

29. A method comprising:

providing an implantable device having a device body including a cavity therein, including providing at least one of a lead adapted to assist in conducting electrical signals to and from a heart or a cardiac rhythm management device electrically couplable to the heart for sensing or stimulation thereof;

coupling a chemical sensor with the device body near or directly adjacent to the cavity;

disposing a drug eluting substance on a portion of the device body, including filling the cavity of the device body with the drug elating substance; and

preventing fibrotic growth with the drug elating substance.

30. The method as recited in claim 29, further comprising binding the drug eluting substance with a polymer.

31. The method as recited in claim 29, wherein filling the cavity with the drug eluting substance includes compressing a platelet inhibitor drug and forming a capsule, and disposing the capsule within the cavity of the device body.

32. The method as recited in claim 29, wherein filling the cavity with the drug elating substance includes compressing a drug with a starch and pressure molding the drug into a predetermined shape, and disposing the molded drug into the cavity of the device body.

33. The method as recited in claim 29, further comprising forming an esterified drug elating substance prior to disposing the drug elating substance on the portion of the device body.

34. The method as recited in claim 29, further comprising mixing a drug with liquid silicone to form the drug eluting substance.

35. The method as recited in claim 34, further comprising curing the drug and liquid silicone after the drug and liquid silicone are disposed in the cavity of the device body.

36. The method as recited in claim 29, further comprising mixing a drug with a hydrogel to form the drug elating substance.