Method and apparatus for analyte sensing
First Claim
1. A glucose sensor for implantation within subcutaneous tissue of an animal body, the glucose sensor comprising:
- a first chamber containing (i) first magnetic particles and (ii) a first hydrocolloid solution having a viscosity which is dependent on and/or a function of the concentration of glucose in the first chamber, wherein the first magnetic particles are dispersed in the first hydrocolloid solution and wherein, when the first chamber is implanted in subcutaneous tissue of the animal body, glucose in the animal body may enter and exit the first chamber; and
a reference chamber containing (i) second magnetic particles and (ii) a reference solution wherein the second magnetic particles are dispersed in the reference solution, and wherein, when the reference chamber is implanted in subcutaneous tissue of the animal body, glucose in the animal body does not enter the reference chamber.
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Abstract
In one aspect, the present invention is directed to a glucose sensing device for implantation within subcutaneous tissue of an animal body. In one embodiment, the glucose sensing device includes a first chamber containing first magnetic particles and a hydrocolloid solution (for example, ConA-dextran hydrocolloid) wherein the first magnetic particles are dispersed in the hydrocolloid solution. In operation, glucose within the animal may enter and exit the first chamber and the hydrocolloid solution changes in response to the presence or concentration of glucose within the first chamber. The sensing device also includes a reference chamber containing second magnetic particles and a reference solution wherein the second magnetic particles are dispersed in the reference solution. The reference solution (for example, oil or alcohol compounds) includes a known or fixed viscosity. The reference solution may also be a hydrocolloid solution (for example, ConA-dextran hydrocolloid). The first and/or second magnetic particles may include amine-terminated particles, at least one rare earth element (for example, neodymium or samarium), and/or a ferromagnetic material.
196 Citations
66 Claims
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1. A glucose sensor for implantation within subcutaneous tissue of an animal body, the glucose sensor comprising:
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a first chamber containing (i) first magnetic particles and (ii) a first hydrocolloid solution having a viscosity which is dependent on and/or a function of the concentration of glucose in the first chamber, wherein the first magnetic particles are dispersed in the first hydrocolloid solution and wherein, when the first chamber is implanted in subcutaneous tissue of the animal body, glucose in the animal body may enter and exit the first chamber; and a reference chamber containing (i) second magnetic particles and (ii) a reference solution wherein the second magnetic particles are dispersed in the reference solution, and wherein, when the reference chamber is implanted in subcutaneous tissue of the animal body, glucose in the animal body does not enter the reference chamber. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 60, 61, 62, 63, 64, 65, 66)
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16. A glucose sensing system comprising:
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a glucose sensor which is implanted in subcutaneous tissue of an animal body, the glucose sensor including; a first chamber containing (i) first magnetic particles and (ii) a hydrocolloid solution having a viscosity which is dependent on and/or a function of the concentration of glucose in the first chamber, wherein the first magnetic particles are dispersed in the hydrocolloid solution and wherein, when the first chamber is implanted in subcutaneous tissue of an animal body, glucose in the animal body may enter and exit the first chamber; and a reference chamber containing (i) second magnetic particles and (ii) a reference solution wherein the second magnetic particles are dispersed in the reference solution; and instrumentation to determine data which is representative of a change in viscosity of the hydrocolloid solution in the first chamber. - View Dependent Claims (17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29)
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30. A glucose sensor for measuring the concentration of glucose in a fluid medium, the glucose sensing comprising:
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a first chamber containing (i) first magnetic particles and (ii) a hydrocolloid solution having a viscosity which is dependent on and/or a function of the concentration of glucose in the first chamber, wherein the first magnetic particles are dispersed in the hydrocolloid solution and wherein, when the first chamber is in fluidic contact with the fluid medium, glucose from the fluid medium may enter and exit the first chamber; and a reference chamber containing (i) second magnetic particles and (ii) a reference solution wherein the second magnetic particles are dispersed in the reference solution, and wherein, when the reference chamber is in fluidic contact with the fluid medium, glucose from the fluid medium does not enter the reference chamber. - View Dependent Claims (31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48)
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49. A glucose sensor for measuring the concentration of glucose in a fluid, the glucose sensing comprising:
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a first chamber; a first plurality of magnetic particles disposed in the first chamber; a first solution disposed in the first chamber, wherein the first solution includes a viscosity which is dependent on and/or a function of the concentration of glucose in the first chamber; and wherein the first plurality of magnetic particles are dispersed in the first solution and wherein, when the first chamber is in fluidic contact with the fluid, glucose in the fluid may enter and exit the first chamber. - View Dependent Claims (50, 51, 52, 53, 54, 55, 56, 57, 58, 59)
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Specification