Systems and procedures for treating cardiac arrest

• US 7,226,427 B2
• Filed: 06/06/2003
• Issued: 06/05/2007
• Est. Priority Date: 05/12/2003
• Status: Active Grant

• Current Assignee: Physio-Control Incorporated (Stryker Corporation)
• Original Assignee: Jolife AB (Stryker Corporation)
• Inventors: Steen, Stig
• Primary Examiner(s): DEMILLE, DANTON D
• Application Number:
  US10/456,088
• Publication Number:
  US 20040230140A1
• Time in Patent Office: 1,460 Days
• Field of Search: 601/41, 601/44, 128/204.18
• US Class Current: 601/44
• CPC Class Codes: A61H 2201/0157 portable
• CPC Class Codes: A61H 2201/107 Respiratory gas
• CPC Class Codes: A61H 2201/1246 by piston-cylinder systems
• CPC Class Codes: A61H 2201/5007 computer controlled
• CPC Class Codes: A61H 2230/105 used as a control parameter for the apparatus
• CPC Class Codes: A61H 31/006 Power driven
• CPC Class Codes: A61H 31/008 Supine patient supports or bases, e.g. improving air-way access to the lungs
• CPC Class Codes: A61M 16/0048 Mouth-to-mouth respiration teaching or training models G09B23/288
• CPC Class Codes: A61M 16/024 including calculation means, e.g. using a processor
• CPC Class Codes: A61M 16/04 Tracheal tubes catheters in general A61M25/00
• CPC Class Codes: A61M 16/06 Respiratory or anaesthetic masks
• CPC Class Codes: A61M 16/202 electrically actuated
• CPC Class Codes: A61M 16/204 used for inhalation control
• CPC Class Codes: A61M 16/205 used for exhalation control
• CPC Class Codes: A61M 2016/0027 pressure meter
• CPC Class Codes: A61M 2205/3331 Pressure; Flow
• CPC Class Codes: A61N 1/39044 in combination with cardiopulmonary resuscitation [CPR] therapy
• CPC Class Codes: Y10S 601/10 Artificial respiration combined with non-artificial respiration therapy

Abstract

Improved procedures for cardiopulmonary resuscitation of a victim of cardiac arrest are provided. In the resuscitation, the victim'"'"'s chest is mechanically compressed and decompressed to stimulate the heart. The victim is induced to inspire and expire against insufflating breathing gas during the chest compression/decompressions. The breathing gases are adduced under pressure to promote the development of a positive coronary perfusion pressure.

Electro-stimulation of the heart can be carried after positive coronary perfusion pressures have been achieved. The electro-stimulation can be defibrillation or heart pacing or both. The chest compression/decompression cycles and the electro-stimulation measures are synchronized to promote sufficiently body circulation of oxygenated blood in a subject suffering from cardiac arrest. Medical equipment systems are provided for implementing the CPR procedures.

Claims

1. A method for cardiopulmonary resuscitation of a person, comprising:

providing a breathing gas under positive pressure to the airways of the person;

mechanically stimulating the person'"'"'s heart using a pneumatic drive unit to reciprocate a rod for compressing and decompressing the person'"'"'s chest while inducing the person to inspire and expire against the positive pressure of the breathing gas for at least a period of time until a positive coronary perfusion pressure develops; and

electrically stimulating the heart once the positive coronary perfusion pressure exceeds a threshold pressure, wherein the pneumatic drive unit is driven by a gas that is recycled for use as the breathing gas.

2. The method of claim 1 wherein the threshold value of the coronary perfusion pressure is selected in the range of about 10 mm Hg to about 25 mm Hg.

3. The method of claim 1, wherein the breathing gas is cooled to a temperature of about at least 5°

C. below the ambient temperature.

4. The method of claim 1, wherein the positive pressure of breathing gas maintained in the person'"'"'s lungs is in the range from about from 1 mm Hg to 30 mm Hg.

5. The method of claim 1 further comprising administering medications using the breathing gas as a carrier.

6. The method of claim 1 wherein mechanically stimulating the person'"'"'s heart comprises using the drive unit to compress the person'"'"'s chest to a compression depth, further comprising adjusting the drive unit to control the compression depth in response to changes in the chest resistance during the course of cardiopulmonary resuscitation of the person.

7. The method of claim 1 wherein mechanically stimulating the person'"'"'s heart comprises externally compressing and decompressing the person'"'"'s chest.

8. The method of claim 7, wherein externally compressing and decompressing the person'"'"'s chest comprises compressing the person'"'"'s chest at a rate between about 60 cycles/mm to about 200 cycles/mm.

9. The method of claim 7, wherein externally compressing and decompressing the person'"'"'s chest further comprises:

in cycles, compressing the chest to a fully compressed state in a compression phase of a cycle; and

decompressing the person'"'"'s chest to a fully decompressed state in a decompression phase of the cycle, and wherein the transition times in cycling between the two states are no more than a fraction of a cycle period.

10. The method of claim 7, wherein the positive pressure of breathing gas is maintained in the person'"'"'s lungs while the person'"'"'s chest is decompressed.

11. The method of claim 9 wherein the fully compressed state corresponds to a static portion of the compression phase, and wherein electrically stimulating the heart according to claim 1 further comprises initiating defibrillation within the last third of the static portion of the compression phase.

12. The method of claim 9 wherein electrically stimulating the heart according to claim 1 comprises initiating pacing the heart in a time interval in between the start of the compression phase and the start of the decompression phase.

13. The method of claim 12, wherein a transition from a decompressed state to the fully compressed state corresponds to a dynamic portion of the compression phase, and wherein the time interval is within 0.10 to 0.15 seconds before the end of the dynamic compression phase.

14. The method of claim 1 wherein the period of time for which the person'"'"'s heart is mechanically stimulated is adjusted in proportion to the duration of asystolia undergone by the person'"'"'s heart.

15. The method of claim 1 further comprising:

assessing the state of the person'"'"'s heart; and

accordingly selecting a method for electrically stimulating the heart.

16. The method of claim 1 wherein the person'"'"'s heart is concurrently both mechanically stimulated and electrically stimulated.

17. The method of claim 1 wherein the person'"'"'s heart is alternately mechanically stimulated and electrically stimulated.

18. The method of claim 1 wherein electrically stimulating the person'"'"'s heart comprises defibrillation.

19. The method of claim 1 wherein electrically stimulating the person'"'"'s heart comprises applying heart pacing pulses.

20. The method of claim 19 wherein a pacing pulse rate is proportional to a cycle rate of concurrently administered chest compression/decompression cycles.

21. The method of claim 20, wherein the pacing pulse rate is substantially flat when the cycle rate is below about 80 cycles/mm and then increases substantially linearly with the cycle rate when the cycle rate exceeds about 80 cycles/min.

22. The method of claim 1, wherein electrically stimulating the heart further comprises initiating electric stimulation after a quantity of blood is accumulated in the left ventricle of the person.

23. The method of claim 1, wherein electrically stimulating the heart further comprises initiating electric stimulation after a time average-mean volume of blood pooled in the right atrium of the person has been substantially reduced by the mechanical stimulation of the heart.

24. The method of claim 1 wherein electrically stimulating the person'"'"'s heart comprises using a stimulation method selected based on an evaluation of the person'"'"'s heart condition during the course of the cardiopulmonary resuscitation.

25. The method of claim 24 wherein the evaluation comprises ECG analysis.

26. A system for administering steps in a course of cardiopulmonary resuscitation to a person, comprising:

a chest compression device for administering mechanical stimulation to the person'"'"'s heart using a pneumatic drive unit to reciprocate a rod for compressing and decompressing the person'"'"'s chest;

a module for administering electric stimulation to the heart;

a control unit for coordinating the administration of mechanical and electric stimulation to the heart over the course of the cardiopulmonary resuscitation; and

means for supplying pressurized breathing gas to the person'"'"'s lungs during the course of the cardiopulmonary resuscitation, wherein the pneumatic drive unit operates on a gas, and wherein the means for supplying the pressurized breathing gas recycles the gas that is used to operate the pneumatic drive unit.

27. The system of claim 26 wherein the control unit further comprises an analysis unit for assessing the state of the person'"'"'s heart during the course of the cardiopulmonary resuscitation.

28. The system of claim 27 wherein the analysis unit is an electrocardiogram recorder/analyzer.

29. The system of claim 27 wherein the control unit comprises a program for automatically modifying steps in the course of the cardiopulmonary resuscitation in response to assessments made by the analysis unit.

30. The system of claim 26 wherein the means for supplying pressurized breathing gas to the person'"'"'s lungs comprises means for disposing medication in the breathing gas for administration to the person.

31. A method for administering a course of cardiopulmonary resuscitation to a person using the system of claim 26, comprising;

assessing an improvement in heart function by the administration of mechanical stimulation to the heart; and

administering electric stimulation to the person'"'"'s heart after the improvement in heart function crosses a threshold.

32. The method of claim 31 wherein assessing the improvement in heart function comprises evaluating at least one parameter from the group of parameters that includes:

a percent reduction in the volume of blood pooled in the right atrium of the person;

a quantity of blood accumulated in the left ventricle of the person; and

a coronary perfusion pressure.

33. The method of claim 31 further comprising applying breathing gas under pressure to the airways of the person during mechanical stimulation of the heart for raising the coronary perfusion pressure.

34. A non-invasive method of re-establishing adequate circulation in a person under cardiac arrest comprising:

providing a breathing gas under positive pressure to the airways of said person;

mechanically stimulating the heart of said person using a pneumatic drive unit to reciprocate a rod for repeatedly compressing and decompressing the person'"'"'s chest at a rate from 60 cycles per minute to 200 cycles per minute, while making the person inspire and expire against the positive pressure of the breathing gas for a period of time sufficient to establish a positive coronary perfusion pressure;

consecutively to the start of the provision of said breathing gas and said compression and decompression, providing electro-stimulation, with the proviso that the electro-stimulation is provided only consecutively to the establishment of a positive coronary blood pressure, while continuing with mechanical stimulation and provision of said positive pressure gas; and

optionally repeating the steps of exclusive mechanical stimulation and mechanical stimulation concomitant with electro-stimulation, wherein the pneumatic drive unit is driven by the breathing gas, and wherein the breathing gas inspired by the person during said mechanical stimulation is substantially breathing gas consumed in driving said pneumatic drive unit.

35. The method of claim 34, wherein the compression and decompression is administered so that the time from going from a fully compressed state to a fully decompressed state and vice-versa extends over a period corresponding to from about a sixth of a compression/decompression cycle to about a tenth of a compression/decompression cycle.

36. The method of claim 34, wherein a positive pressure of breathing gas is maintained in the lung of the person during decompression.

37. The method of claim 36, wherein the arithmetic mean of said positive pressure of breathing gas in the lung over the decompression phase (DC) of a breathing cycle is from 1 mm Hg to 30 mm Hg.

38. The method of claim 34, wherein the provision of electro-stimulation is started once a positive coronary perfusion pressure of 10 mm Hg has been obtained.

39. The method of claim 34, wherein the provision of electro-stimulation is started once a positive perfusion pressure of 15 mm Hg or more has been obtained.

40. The method of claim 34, wherein defibrillating electro-stimulation (DF) is provided during the last third of the static portion of the compression phase (STCP) of a compression/decompression cycle.

41. The method of claim 34, wherein pacing electro-stimulation (PC) is provided within the time period from the start of the compression phase (CP) until the start of the decompression phase (DCP) of a compression/decompression cycle.

42. The method of claim 34, wherein pacing electro-stimulation (PC) is provided within a time period of 0.10 to 0.15 seconds from the end of the dynamic compression phase (DNCP) of a compression/decompression cycle.

43. The method of claim 34, wherein the rate of mechanical stimulation is from 80 cycles per minute to 200 cycles per minute.

44. The method of claim 34, comprising an intermittent estimation of the compression resistance of the breast of the person.

45. The method of claim 44, wherein the result of said estimation is used for control of the compression force applied to the breast of the person.

46. The method of claim 34, wherein the period of time required for establishing a positive coronary perfusion pressure is from 30 seconds and more in the case of a preceding short period of asystolia lasting from 10 seconds to 50 seconds, and up to five minutes and more in the case of a preceding longer period of asystolia lasting at least two.

47. The method of claim 34, wherein mechanical stimulation is continued after the provision of electro-stimulation and re-establishment of circulation.

48. The method of claim 34, wherein electro-stimulation is by defibrillation.

49. The method of claim 34, wherein electro-stimulation is by pacing.

50. The method of claim 49 wherein the pacing rate is about 80 beats per minute at a compression/decompression rate of up to 80 cycles per minute, and is made to follow the compression rate if the latter surpasses the basic rate.

51. The method of claim 34, wherein the breathing gas, if provided by intubation, has a temperature of 5°

C. or more below the ambient temperature.

52. The method of claim 51, wherein said breathing gas temperature is 10°

C. or more below the ambient temperature.

53. The method of claim 34, wherein a cooling aqueous spray is administered to the person by means of the breathing gas which acts as a carrier.

54. The method of claim 34, wherein a medicament is administered to the person by means of at least one of the following:

(1) the breathing gas and (2) an aqueous spray for which the breathing gas acts as a carrier, for at least one of the following;

(1a) alleviating the effects of cardiac arrest and (2a) assisting in the re-establishment of circulation.

55. The method of claim 34, wherein administration of electro-stimulation is started once a minimum of 20 ml or more of blood has accumulated in the left ventricle of the person in case of an adult person.

56. The method of claim 34, wherein administration of electro-stimulation is started once the time average-mean volume of blood in the right atrium at asystole or ventricular fibrillation has been reduced by 50% or more by mechanical compression/decompression.

57. An apparatus for resuscitating a person under cardiac arrest comprising:

a reciprocating means for mechanical stimulation of the heart;

a means for the electric stimulation of the heart;

a means for controlling the provision of mechanical and electric stimulation over time to allow electric stimulation to be provided once at least one of the following conditions has been obtained (1) the time average-mean volume of blood in the right atrium of the person at asystole has been reduced by at least 50%, (2) ventricular fibrillation has been reduced by at least 50%, (3) 20 ml or more of blood has accumulated in the left ventricle of the person, and (4) a positive coronary perfusion pressure threshold;

a means for adducing breathing gas under pressure to the airways of the person;

a source of compressed breathing gas for providing breathing gas to the person being resuscitated coupled with the gas adducing means; and

a means for controlling the pressure of the breathing gas provided to the person, wherein the source of compressed breathing gas is designed to provide gas for driving the reciprocating means, and wherein the gas for driving the reciprocating means is the breathing gas provided to the person.

58. The apparatus of claim 57, wherein the means for controlling the provision of mechanical and electric stimulation comprises the means for controlling the pressure of the breathing gas provided to the person.

59. The apparatus of claim 57, further comprising an administration means for administering to the person under resuscitation a medicament for achieving at least one of (1) alleviating the effects of cardiac arrest and (2) assisting the re-establishment of circulation, the administration means being coupled to the gas adducing means and being capable of producing an aqueous spray containing the medicament.

60. The apparatus of claim 57, wherein the positive coronary perfusion pressure threshold is about 10 mm HG.

61. The apparatus of claim 57, wherein the positive coronary perfusion pressure threshold is about 15 mm HG.

62. The apparatus of claim 57, wherein the positive coronary perfusion pressure threshold is about 25 mm HG or more.

63. An apparatus for re-establishing circulation in a person under cardiac arrest comprising:

a source of compressed breathing gas;

means for providing said breathing gas under positive pressure to the airways of the person;

pneumatic reciprocating means for mechanically stimulating the heart of the person by repeatedly compressing and decompressing the chest at a rate from 60 cycles per minute to 200 cycles per minute;

electrical means for providing electrostimulation to the heart of the person, wherein the compressed breathing gas is used for driving said reciprocating pneumatic means and wherein the breathing gas vented from the reciprocating pneumatic means is used for providing breathing gas under positive pressure to the airways of the person.

64. The apparatus of claim 63, wherein the means for providing breathing gas to the person comprises one of (1) a facial breathing mask and (2) a device for intubation of the person'"'"'s airways.

65. The apparatus of claim 63, wherein the pneumatic reciprocating means comprises a pad disposable so as to abut the breast of the person, and wherein said electrical means for providing electro-stimulation comprises two electrodes, a front electrode to be applied on the breast of the person, the front electrode being positionable adjacent to said pad of the reciprocating means, and a rear electrode disposed so as to be abutable to the back of the person.

66. The apparatus of claim 65, wherein the electrical means for providing electro-stimulation includes a means for analyzing ECG signals picked up by said electrodes and conducted to the ECG analyzing means.

67. The apparatus of claim 63, wherein the pacing frequency of said electrical means is controlled to follow the frequency of mechanical compression/decompression.

68. The apparatus of claim 63, wherein the breathing gas provided to the airways of the person has been used for driving the pneumatic reciprocating means.

69. An apparatus for resuscitating a person under cardiac arrest comprising:

a pneumatic drive unit that reciprocates a rod for compressing and decompressing the person'"'"'s chest, wherein the pneumatic drive unit is driven by compressed breathing gas; and

a detachable means for administering a portion of the breathing gas consumed for driving the drive unit to the airways of the person at a positive pressure over a time period of 1 minute or more.

70. The apparatus of claim 69, wherein said breathing gas is at least 50% oxygen by volume.

71. The apparatus of claim 69, wherein said detachable means is one of (1) a facial mask, (2) an endotracheal tube, and (3) a tube for exotracheal intubation.

72. A system for administering steps in a course of cardiopulmonary resuscitation to a person, comprising:

a chest compression device for administering mechanical stimulation to the person'"'"'s heart;

a module for administering electric stimulation to the heart;

a control unit for co-ordinating the administration of mechanical and electric stimulation to the heart over the course of the cardiopulmonary resuscitation;

an analysis unit for assessing the state of the person'"'"'s heart during the course of the cardiopulmonary resuscitation, wherein the control unit comprises a program for automatically modifying steps in the course of the cardiopulmonary resuscitation in response to assessments made by the analysis unit; and

means for supplying pressurized breathing gas to the person'"'"'s lungs during the course of cardiopulmonary resuscitation, wherein the chest compression device is a pneumatic device operating on a gas, and wherein the means for supplying pressurized breathing gas recycles the gas used to operate the pneumatic device.

73. The system of claim 72, wherein the analysis unit is an electrocardiogram recorder/analyzer.

74. The system of claim 72, wherein the means for supplying pressurized breathing gas to the person'"'"'s lungs comprises means for disposing medication in the breathing gas for administration to the person.