Closed loop system and method for controlling muscle activity via an intrathecal catheter

• US 7,226,430 B2
• Filed: 12/26/2003
• Issued: 06/05/2007
• Est. Priority Date: 12/26/2003
• Status: Active Grant

• Current Assignee: Codman & Shurtleff Incorporated (Johnson & Johnson)
• Original Assignee: Codman & Shurtleff Incorporated (Johnson & Johnson)
• Inventors: Ludin, Lev
• Primary Examiner(s): MENDEZ, MANUEL A
• Application Number:
  US10/745,715
• Publication Number:
  US 20050148927A1
• Time in Patent Office: 1,257 Days
• Field of Search: 604/67, 604/66, 604/65, 128/DIG.12, 128/13, 600300-301, 607 29- 32, 607/60
• US Class Current: 604/67
• CPC Class Codes: A61M 2202/0464 Cerebrospinal fluid
• CPC Class Codes: A61M 2205/33 Controlling, regulating or measuring
• CPC Class Codes: A61M 2205/3523 using telemetric means
• CPC Class Codes: A61M 2205/3561 local, e.g. within room or hospital
• CPC Class Codes: A61M 5/14276 specially adapted for implantation
• CPC Class Codes: A61M 5/1723 using feedback of body parameters, e.g. blood-sugar, pressure measurement of body parameters A61B5/00

Abstract

A closed loop feedback drug delivery system for controlling muscle activity, e.g., spasticity. The system includes a sensor, e.g., an EMG sensor, for monitoring muscle activity and generating a detected muscle activity signal. A controller automatically adjusts at least one of timing and dosage of a drug administered to control muscle activity based on the detected muscle activity signal and produces a control signal. Administering of the drug, e.g., an antispasmodic drug, for controlling muscle activity based on the control signal is performed by an infusion pump. The drug after being emitted from the pump is then delivered to the spinal cord of the patient using an intrathecal catheter.

Claims

1. A closed loop feedback drug delivery system for controlling muscle activity comprising:

a sensor for monitoring abnormal muscle activity and generating a detected muscle activity signal;

a controller for automatically adjusting at least one of timing and dosage of a drug administered to control muscle activity based on the detected muscle activity signal and producing a control signal;

a pump for administering the drug for controlling muscle activity based on the control signal; and

an intrathecal catheter delivering the drug dispensed from said pump to the spinal column.

2. The system in accordance with claim 1, wherein the muscle activity is involuntary.

3. The system in accordance with claim 2, wherein the muscle activity is spasticity.

4. The system in accordance with claim 1, wherein the sensor is an EMG sensor in the form of one of a single surface electrode, a surface electrode array, a needle electrode, or a needle electrode array.

5. The system in accordance with claim 1, wherein said controller is wired to said pump.

6. The system in accordance with claim 1, wherein said controller communicates with said pump via wireless communication.

7. The system in accordance with claim 6, wherein the wireless communication is via a telemetric link.

8. A method for controlling muscle activity using a closed loop feedback drug delivery system, comprising the steps of:

monitoring abnormal muscle activity and generating a detected muscle activity signal;

automatically adjusting at least one of timing and dosage of a drug administered to control muscle activity based on the detected muscle activity signal and producing a control signal;

administering a drug for controlling muscle activity based on the control signal; and

delivering the drug to be administered via an intrathecal catheter to the spinal column.

9. The method in accordance with claim 8, wherein said monitoring step comprises positioning externally a sensor proximate a muscle to be monitored.

10. The method in accordance with claim 9, wherein the sensor is disposed to monitor muscle activity in at least one of a hand, arm, foot, leg, facial muscle, or back muscle.

11. The method in accordance with claim 8, wherein said muscle activity is spasticity.

12. The method in accordance with claim 8, wherein said muscle activity is monitored using an EMG sensor in the form of one of a single surface electrode, a surface electrode array, a needle electrode, or a needle electrode array.

13. The method in accordance with claim 8, wherein said adjusting step comprises receiving the detected muscle activity signal via wireless communications.

14. The method in accordance with claim 13, wherein the wireless communication is via a telemetric link.

15. A method for controlling muscle activity using a closed loop feedback drug delivery system, comprising the steps of:

monitoring naturally occurring muscle activity and generating a detected muscle activity signal;

automatically adjusting at least one of timing and dosage of a drug administered to control muscle activity based on the detected muscle activity signal and producing a control signal;

administering a drug for controlling muscle activity based on the control signal; and

delivering the drug to be administered via an intrathecal catheter to the spinal column.

16. A closed loop feedback drug delivery system for controlling muscle activity comprising:

a sensor for monitoring naturally occurring muscle activity and generating a detected muscle activity signal;

a controller for automatically adjusting at least one of timing and dosage of a drug administered to control muscle activity based on the detected muscle activity signal and producing a control signal;

a pump for administering the drug for controlling muscle activity based on the control signal; and

an intrathecal catheter delivering the drug dispensed from said pump to the spinal column.