Expandable foam-like biomaterials and methods
First Claim
1. A kit for forming a solid cellular foam proteinaceous biopolymeric material comprising separate reactable aliquot portions consisting of a first aqueous solution containing a proteinaceous material, and a second aqueous solution which is reactable with, the proteinaceous component of the first aqueous solution to form a solid proteinaceous biopolymeric material in response to mixing of said first and second aqueous solutions, wherein the first aqueous solution includes a blowing agent, and wherein said second aqueous solution includes an acidic titrant reactable on contact with the blowing agent sufficient to evolve a gas to impart a cellular foam structure to the proteinaceous biopolymeric material concurrently while said proteinaceous material of said first aqueous solution reacts with said second aqueous solution to form said solid proteinaceous biopolymeric material.
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Accused Products
Abstract
Liquid, injectable, aqueous solutions are transformed in situ to an expandable foam-like, space filling, and adherent biomaterial. Preferably, the foam-like biomaterial is the reaction product of a two-part liquid system to achieve the in situ formation thereof. The liquid system is generally comprised of a protein solution and a cross linker solution which may either be premixed and then applied to a site in need of the biomaterial, or simultaneously mixed and delivered through an in-line mixing/dispensing tip directly to the site. In especially preferred embodiments, an expandable foam-like biomaterial includes the reaction product of human or animal-derived protein material and a di- or polyaldehyde in the presence of a bicarbonate and an acidic titrant amounts sufficient to impart a cellular foam structure to the material.
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Citations
20 Claims
- 1. A kit for forming a solid cellular foam proteinaceous biopolymeric material comprising separate reactable aliquot portions consisting of a first aqueous solution containing a proteinaceous material, and a second aqueous solution which is reactable with, the proteinaceous component of the first aqueous solution to form a solid proteinaceous biopolymeric material in response to mixing of said first and second aqueous solutions, wherein the first aqueous solution includes a blowing agent, and wherein said second aqueous solution includes an acidic titrant reactable on contact with the blowing agent sufficient to evolve a gas to impart a cellular foam structure to the proteinaceous biopolymeric material concurrently while said proteinaceous material of said first aqueous solution reacts with said second aqueous solution to form said solid proteinaceous biopolymeric material.
- 12. A kit for forming a solid cellular foam proteinaceous biopolymeric material comprising separate reactable aliquot portions consisting of a first aqueous solution containing bovine or human serum albumin, and a second aqueous solution containing a di- or polyaldehyde which is reactable with the bovine or human serum albumin of the first aqueous solution to form a solid proteinaceous biopolymeric material in response to mixing of said first and second aqueous solutions, wherein one of the first and second aqueous solutions includes a blowing agent, and wherein the other of said first and second aqueous solutions includes an acidic titrant reactable on contact with the blowing agent sufficient to evolve a gas to impart a cellular foam structure to the proteinaceous biopolymeric material concurrently while said bovine or human serum albumin of said first aqueous solution reacts with said di- or polyaldehyde of said second aqueous solution to form said solid proteinaceous biopolymeric material.
Specification