Method and apparatus for detecting vagus nerve stimulation

• US 7,228,167 B2
• Filed: 04/09/2004
• Issued: 06/05/2007
• Est. Priority Date: 04/10/2003
• Status: Expired due to Fees

• Current Assignee: Mayo Foundation For Medical Education And Research (Mayo Clinic)
• Original Assignee: Mayo Foundation For Medical Education And Research (Mayo Clinic)
• Inventors: Somers, Virend K., Kara, Tomas
• Primary Examiner(s): Evanisko; George R.
• Assistant Examiner(s): KAHELIN, MICHAEL WILLIAM
• Application Number:
  US10/821,778
• Publication Number:
  US 20040260356A1
• Time in Patent Office: 1,152 Days
• Field of Search: 607/1, 607/2, 607/6, 607/62, 600/508, 600/510, 600/554
• US Class Current: 600/509
• CPC Class Codes: A61B 5/0205 Simultaneously evaluating both cardiovascular conditions and different types of body conditions, e.g. heart and respiratory condition
• CPC Class Codes: A61B 5/021 Measuring pressure in heart or blood vessels A61B5/0205 takes precedence
• CPC Class Codes: A61B 5/0816 Measuring devices for examining respiratory frequency measuring frequency of electric signals G01R23/00
• CPC Class Codes: A61B 5/318 Heart-related electrical modalities, e.g. electrocardiography [ECG]
• CPC Class Codes: A61B 5/369 Electroencephalography [EEG] devices for psychotechnics A61B5/16
• CPC Class Codes: A61B 5/4094 Diagnosing or monitoring seizure diseases, e.g. epilepsy
• CPC Class Codes: A61N 1/0526 Head electrodes A61N1/0551 takes precedence

Abstract

A method and apparatus for monitoring the application of a vagus nerve stimulation signal includes a detection circuit having an amplifier, a filter, and a signal prolongation circuit. The signal prolongation circuit rectifies a detected vagus nerve signal and provides the signal to a Schmitt trigger extending the length of the signal. Because of the prolongation of the signal, the signal can be sampled at a relatively low rate, and real time data illustrating the response of various physiological signals to the application of the vagus nerve signal can be monitored, thereby providing clinical data for monitoring and adjusting the applied stimulation.

Claims

1. A method for non-invasive detection of a vagus nerve stimulation signal, the method comprising the following steps:

applying external electrodes to a patient in proximity to an implanted vagus nerve stimulator;

detecting a vagus nerve stimulation signal applied by the stimulator to the patient with said electrodes;

amplifying the detected vagus nerve stimulation signal;

filtering the detected vagus nerve stimulation signal in a bandwidth selected to eliminate extraneous noise; and

prolonging the detected signal to allow sampling of the vagus nerve stimulation signal and to trigger sampling of at least one other physiological signal to allow for monitoring the effect of the vagus nerve stimulation on the at least one other physiological signal.

2. The method as defined in claim 1, further comprising the step of comparing the detected vagus nerve stimulation signal to a threshold level prior to prolonging the vagus nerve stimulation signal.

3. The method as defined in claim 1, further comprising the step of electrically isolating the amplified input signal.

4. The method as defined in claim 1, further comprising the step of rectifying the filtered signal.

5. The method as defined in claim 1, further comprising the step of producing an alarm signal providing at least one of a visual or an audio signal to a user indicating that the vagus nerve stimulation signal has been detected.

6. The method as recited in claim 1, further comprising the step of retaining the filtered signal at a predetermined output signal level for a period of time selected to provide a prolonged vagus nerve stimulation signal allowing sampling of a lower rate than the filtered signal.

7. The method as defined in claim 1, further comprising the step of electrically isolating the detected vagus nerve stimulation signal from the filtered vagus nerve stimulation signal and the prolonged vagus nerve stimulation signal.

8. The method as defined in claim 2, further comprising the step of rectifying the filtered vagus nerve stimulation signal prior to the step of comparing the filtered vagus nerve stimulation signal to the threshold value.

9. The method of claim 1, further comprising the step of detecting an analog signal representative of at least one electrocardiogram (EGG), an electroencephalogram (EEG), a blood pressure measurement, and a breathing measurement.

10. The method as defined in claim 9, further comprising the step of electrically connecting each of the vagus nerve stimulation signal and the physiological signal to a controller, the controller being programmed to monitor the physiological signal as a function of the vagus nerve signal.

11. The method as defined in claim 10, further comprising the step of storing at least one of the filtered and the prolonged vagus nerve stimulation signal and the physiological signal as a function of time.

12. The method as defined in claim 10, further comprising the step of displaying the physiological signal and the at least one of the filtered and the prolonged vagus nerve stimulation signal.

13. The method as defined in claim 12, further comprising the step of providing at least one of a visual and an audio output when the prolonged vagus nerve stimulation signal is detected.