Ethylenedicysteine (EC)-drug conjugates, compositions and methods for tissue specific disease imaging
First Claim
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1. A method of delivering a radionuclide into target cells of a human subject, comprising:
- a) obtaining a composition comprising a radionuclide-labeled bis-aminoethanethiol (BAT) dicarboxylic acid-targeting ligand conjugate; and
b) administering the conjugate to the subject, wherein the conjugate is take up into the target cells.
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Abstract
The invention provides, in a general sense, a new labeling strategy employing 99mTc chelated with ethylenedicysteine (EC). EC is conjugated with a variety of ligands and chelated to 99mTc for use as an imaging agent for tissue-specific diseases. The drug conjugates of the invention may also be used as a prognostic tool or as a tool to deliver therapeutics to specific sites within a mammalian body. Kits for use in tissue-specific disease imaging are also provided.
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Citations
30 Claims
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1. A method of delivering a radionuclide into target cells of a human subject, comprising:
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a) obtaining a composition comprising a radionuclide-labeled bis-aminoethanethiol (BAT) dicarboxylic acid-targeting ligand conjugate; and b) administering the conjugate to the subject, wherein the conjugate is take up into the target cells. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30)
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Specification