Resynchronization method and apparatus based on intrinsic atrial rate

• US 7,231,248 B2
• Filed: 07/21/2003
• Issued: 06/12/2007
• Est. Priority Date: 03/16/2001
• Status: Expired due to Term

• Current Assignee: Cardiac Pacemakers Incorporated (Boston Scientific Corporation)
• Original Assignee: Cardiac Pacemakers Incorporated (Boston Scientific Corporation)
• Inventors: Kadhiresan, Veerichetty, Ding, Jiang, Kramer, Andrew P., Vanderlinde, Scott, Baumann, Lawrence
• Primary Examiner(s): Schaetzle; Kennedy
• Application Number:
  US10/624,458
• Publication Number:
  US 20050038477A1
• Time in Patent Office: 1,422 Days
• Field of Search: 607/9, 607/14, 607/15, 607/22, 607/24, 607/25, 607/27, 600/516, 600/519, 600/526
• US Class Current: 607/9
• CPC Class Codes: A61N 1/3627 for treating a mechanical deficiency of the heart, e.g. congestive heart failure or cardiomyopathy
• CPC Class Codes: A61N 1/3682 with a variable atrioventricular delay

Abstract

A method and system for setting the operating parameters of a cardiac rhythm management device in which a plurality of parameter optimization algorithms are available. A measured feature of an electrophysiological signal such as QRS width has been shown to be useful in selecting among certain parameter optimization algorithms. In one embodiment, one or more resynchronization pacing parameters are set based on one or both of the feature extracted from an electrogram signal and the value of a resynchronization pacing parameter which tends to minimize the intrinsic atrial rate.

Claims

1. A method for delivering cardiac resynchronization therapy, comprising:

varying the values of one or more resynchronization pacing parameters while measuring an intrinsic atrial rate;

extracting a feature from an electrogram signal; and

,

setting one or more resynchronization pacing parameters based on one or both of the feature extracted from an electrogram signal and the value of a resynchronization pacing parameter which tends to reduce the intrinsic atrial rate.

2. The method of claim 1 wherein the one or more resynchronization pacing parameters include an AV delay interval.

3. The method of claim 1 wherein the one or more resynchronization pacing parameters include an LV offset for biventricular pacing.

4. The method of claim 1 wherein the one or more resynchronization pacing parameters include a resynchronization pacing mode.

5. The method of claim 1 wherein the one or more resynchronization pacing parameters include which of the ventricles should be paced.

6. The method of claim 1 wherein the feature extracted from an electrogram signal relates to the time required for the ventricles to depolarize during an intrinsic beat.

7. The method of claim 6 wherein the feature extracted from an electrogram signal which relates to the time required for the ventricles to depolarize during an intrinsic beat is a QRS width.

8. The method of claim 6 wherein the feature extracted from an electrogram signal which relates to the time required for the ventricles to depolarize during an intrinsic beat is whether the width of the QRS complex exceeds 160 milliseconds.

9. The method of claim 6 wherein the feature extracted from an electrogram signal which relates to the time required for the ventricles to depolarize during an intrinsic beat is a time difference between right and left ventricular senses.

10. The method of claim 1 wherein the feature extracted from an electrogram signal is the length of a PR interval.

11. A system, comprising:

an implantable pulse generator for delivering resynchronization pacing therapy;

wherein the pulse generator is programmed to vary the values of one or more resynchronization pacing parameters while measuring an intrinsic atrial rate;

a controller programmed to extract a feature from an electrogram signal; and

,

wherein the controller is further programmed to select one or more optimum values of resynchronization pacing parameters based on one or both of the feature extracted from an electrogram signal and the value of a resynchronization pacing parameter which tends to reduce the intrinsic atrial rate.

12. The system of claim 11 wherein the one or more resynchronization pacing parameters include an AV delay interval.

13. The system of claim 11 wherein the one or more resynchronization pacing parameters include an LV offset for biventricular pacing.

14. The system of claim 11 wherein the one or more resynchronization pacing parameters include a resynchronization pacing mode.

15. The system of claim 11 wherein the one or more resynchronization pacing parameters include which of the ventricles should be paced.

16. The system of claim 11 wherein the feature extracted from an electrogram signal relates to the time required for the ventricles to depolarize during an intrinsic beat.

17. The system of claim 16 wherein the feature extracted from an electrogram signal which relates to the time required for the ventricles to depolarize during an intrinsic beat is a QRS width.

18. The system of claim 16 wherein the feature extracted from an electrogram signal which relates to the time required for the ventricles to depolarize during an intrinsic beat is whether the width of the QRS complex exceeds 160 milliseconds.

19. The system of claim 16 wherein the feature extracted from an electrogram signal which relates to the time required for the ventricles to depolarize during an intrinsic beat is a time difference between right and left ventricular senses.

20. The system of claim 11 wherein the feature extracted from an electrogram signal is the length of a PR interval.