Particle dispersion device for nasal delivery

• US 7,231,919 B2
• Filed: 09/30/2002
• Issued: 06/19/2007
• Est. Priority Date: 09/28/2001
• Status: Active Grant

• Current Assignee: Savine Therapeutics Pty
• Original Assignee: Kurve Technology, Inc.
• Inventors: Giroux, Marc
• Primary Examiner(s): Hayes; Michael J.
• Assistant Examiner(s): Mendoza; Michael G.
• Application Number:
  US10/262,430
• Publication Number:
  US 20030079742A1
• Time in Patent Office: 1,723 Days
• Field of Search: 128/203.15, 128/203.17, 128/203.26, 128/203.27, 128/203.28, 128/200.21, 128/200.23, 128/203.12, 128/203.16, 128/203.18, 128/204.24, 128/205.25, 128/203.22, 128/203.29, 128/207.13, 239/338, 239/505, 239/507, 239/513, 239/514, 239/343, 239/366, 239/310, 482/13, 366/101, 366/167.1, 366/165.1, 261/154, 261/130, 261/104, 261/107
• US Class Current: 128/203.15
• CPC Class Codes: A61M 11/00 Sprayers or atomisers specially adapted for therapeutic purposes in general B05B; aerosol containers B65D83/14
• CPC Class Codes: A61M 11/001 Particle size control
• CPC Class Codes: A61M 15/0008 rotating by airflow
• CPC Class Codes: A61M 15/0028 using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
• CPC Class Codes: A61M 15/0086 Inhalation chambers
• CPC Class Codes: A61M 15/08 Inhaling devices inserted into the nose
• CPC Class Codes: A61M 16/06 Respiratory or anaesthetic masks
• CPC Class Codes: A61M 2206/16 Rotating swirling helical flow, e.g. by tangential inflows
• CPC Class Codes: A61M 2210/0618 Nose

Abstract

A nebulizer and a method of breathing using the nebulizer is described. The nebulizer and breathing techniques are capable of delivering medicament into the sinus cavity of a user.

Claims

1. A controlled particle dispersion breathing method, the method performed by a user having a sinus, comprising:

providing a nebulizer having a particle dispersion chamber to a user, the particle dispersion chamber capable of producing nebulized particles;

activating the nebulizer;

breathing a plurality of quick breaths as nebulized particles begin to flow out of the particle dispersion chamber;

creating a pressure in the sinus of the user using the back of the throat;

repeating the breathing of a plurality of quick breaths, holding the quick breaths and creating a pressure in the sinuses;

breathing a plurality of long breaths; and

repeating the breathing of a plurality of quick breaths, holding the quick breaths, creating a pressure in the sinuses and breathing a plurality of long breaths.

2. The method of claim 1, wherein about five quick breaths are breathed.

3. The method of claim 1, wherein about two to four quick breaths are breathed.

4. The method of claim 1, wherein about three quick breaths are breathed.

5. The method of claim 1, wherein about three long breaths are breathed.

6. The method of claim 1, wherein about two long breaths are breathed.

7. The method of claim 1, wherein about one long breath is breathed.

22. A method of delivering a medicament to the nasal cavity and paranasal sinuses, comprising:

providing a particle dispersion device, comprising;

a nasal adapter having an input and an output;

a particle dispersion chamber having an input opening and an output opening, the output opening in communication with the nasal adapter input, the chamber having fluid outputs operative to impart a vortical flow to aerosolized particles exiting the chamber output opening and entering the nasal adapter;

an outflow tube in communication with the input opening of particle dispersion chamber; and

a housing, the housing having a medicine chamber in which a medicine is nebulized or aerosolized, in communication with the outflow tube;

performing the controlled particle dispersion breathing technique of claim 1; and

delivering the medicament.

23. The method of claim 22, wherein the medicament is at least one of a treatment for conditions consisting of sinusitis, allergies, rhinitis, migraine headache, influenza, and the common cold.

36. The breathing method of claim 1, wherein the particle dispersion chamber is suitable to provide for a vortical particle flow therefrom.

8. A particle dispersion device for nasal delivery, comprising:

a nasal adapter having an input and an output;

a particle dispersion chamber having an input opening and an output opening, the output opening in communication with the nasal adapter input, the chamber having directed fluid outputs operative to impart a vortical flow to aerosolized particles exiting the chamber output opening and entering the nasal adapter;

an outflow tube in communication with the input opening of the particle dispersion chamber; and

a housing, the housing having a medicine chamber in which a medicine is nebulized or aerosolized, in communication with the outflow tube.

9. The particle dispersion device of claim 8, wherein the device is capable of delivery of particles sizes ranging from about 2 to about 50 microns, or from about 2 to about 15 microns.

10. The particle dispersion device of claim 8, wherein the nasal adapter has a lip.

11. The particle dispersion device of claim 8, wherein the nasal adapter has a width of about 1½

inches across a bridge of the nasal adapter and a length of about 1½

inches.

12. The particle dispersion device of claim 10, wherein the lip is about ⅛

inch long and capable of forming a seal.

13. The particle dispersion device of claim 8, wherein the outflow tube has an internal diameter of about 9/16 of an inch and a first tapered end.

14. The particle dispersion device of claim 8, wherein the nasal adapter has a plurality of exhaust vents.

15. The particle dispersion device of claim 8, further comprising a band, the band connected to the nasal adapter, wherein the band is capable of securing the nasal adapter to the face of a user.

16. The particle dispersion device of claim 8, further comprising a hose, the hose at one end in communication with the nasal adapter, and the other end with the particle dispersion chamber.

17. The particle dispersion device of claim 16, wherein the hose is an accordion hose.

18. The particle dispersion device of claim 8, further comprising a shut-off timer.

19. The particle dispersion device of claim 8, further comprising a pause feature.

20. The particle dispersion device of claim 8, wherein the medicine chamber comprises a multi-dose compartment.

21. The particle dispersion device of claim 8, further comprising:

a lid for covering the medicine chamber;

a cartridge capable of insertion into the medicine chamber; and

a nebulizing stem connected to the lid, the stem capable of insertion into the cartridge.

24. A particle dispersion chamber, comprising:

a nasal adapter having an input and an output;

a housing having an external surface, an input opening, an output opening, and an internal channel between the openings, the channel generally defining an axis and a forward direction toward the output opening, the output opening in communication with the nasal adapter input; and

a plurality of directional fluid outputs within and communicating with the internal channel, directing output at an acute forward angle with respect to the channel axis and output opening, wherein the fluid outputs, when fluid flows therefrom, are operative to impart a vortical flow to aerosolized particles exiting the output opening and entering the nasal adapter, and wherein the internal channel has a substantially continuous cross-sectional area from and including a location of a fluid output within the internal channel to, and including, the output opening.

25. The particle dispersion chamber of claim 24, wherein the fluid outputs are positioned randomly along the internal channel.

26. The particle dispersion chamber of claim 24, wherein the fluid outputs are positioned in a symmetrical array along the internal channel.

27. The particle dispersion chamber of claim 24, wherein the fluid outputs are jets.

28. The particle dispersion chamber of claim 24, further comprising a dispersion blade located within the internal channel.

29. The particle dispersion chamber of claim 28, wherein the dispersion blade is solid.

30. The particle dispersion chamber of claim 28, wherein the dispersion blade is netting.

31. The particle dispersion chamber of claim 24, further comprising a baffle located within the internal channel.

32. The particle dispersion chamber of claim 31, wherein the baffle is helical in shape.

33. The particle dispersion chamber of claim 24, further comprising an inhaler associated with the particle dispersion chamber.

34. The particle dispersion chamber of claim 24, further comprising a nasal spray inhaler having an actuator, the actuator associated with the particle dispersion chamber.

35. The particle dispersion chamber of claim 24, further comprising a dry powder inhaler associated with the particle dispersion chamber.

37. The particle dispersion chamber of claim 24, wherein the fluid outputs are outputs for a fluid selected from the group consisting of air, compressed air, gas, compressed gas and combinations thereof.

38. A particle dispersion chamber, comprising:

a nasal adapter having an input and an output;

a housing having an external surface, an input opening, an output opening, and an internal channel between the openings, the channel generally defining an axis and a forward direction toward the output opening, the output opening in communication with the nasal adapter input; and

a plurality of directional fluid outputs within and communicating with the internal channel, directing output at an acute forward angle with respect to the channel axis and output opening, wherein the fluid outputs, when fluid flows therefrom, are operative to impart a vortical flow to aerosolized particles exiting the output opening and entering the nasal adapter; and

wherein the internal channel has a substantially constant cross-sectional area from and including a localion a fluid output within the internal channel to, and including, the output opening.