Optical sampling interface system for in vivo measurement of tissue
First Claim
1. A method of compensating measurement bias in noninvasive analyte measurement, said bias resulting from variations in sampled volume and measurement conditions between measurements, comprising the steps of:
- using ananalyzer to provide a tissue measurement;
determining a difference between said tissue measurement and a tissue template associated with a registration position;
mapping the resulting difference to a measurement of a target analyte according to a calibration model; and
applying a baseline adjustment to said analyte measurement.
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Abstract
An optical sampling interface system minimizes and compensates error resulting from sampling variations and measurement site state fluctuations. Components include: An optical probe placement guide having an aperture wherein the optical probe is received, facilitates repeatable placement accuracy on surface of a tissue measurement site with minimal, repeatable disturbance to surface tissue. The aperture creates a tissue meniscus that minimizes interference due to surface irregularities and controls variation in tissue volume sampled; an occlusive element placed over the tissue meniscus isolates the meniscus from environmental fluctuations, stabilizing hydration at the site and thus, surface tension; an optical coupling medium eliminates air gaps between skin surface and optical probe; a bias correction element applies a bias correction to spectral measurements, and associated analyte measurements. When the guide is replaced, a new bias correction is determined for measurements done with the new placement. Separate components of system can be individually deployed.
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Citations
15 Claims
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1. A method of compensating measurement bias in noninvasive analyte measurement, said bias resulting from variations in sampled volume and measurement conditions between measurements, comprising the steps of:
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using ananalyzer to provide a tissue measurement; determining a difference between said tissue measurement and a tissue template associated with a registration position; mapping the resulting difference to a measurement of a target analyte according to a calibration model; and applying a baseline adjustment to said analyte measurement. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15)
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Specification