Polymeric nanofibers for tissue engineering and drug delivery

• US 7,235,295 B2
• Filed: 09/10/2004
• Issued: 06/26/2007
• Est. Priority Date: 09/10/2003
• Status: Expired due to Fees

• Current Assignee: Penn State Research Foundation (Pennsylvania State University)
• Original Assignee: Cato T. Laurencin, Harry R. Allcock, Jared D. Bender, Lakshmi Sreedharan Nair, Paul W. Brown, Subhabrata Bhattacharyya, Yaser E. Greish
• Inventors: Laurencin, Cato T., Brown, Paul W., Nair, Lakshmi Sreedharan, Allcock, Harry R., Bhattacharyya, Subhabrata, Bender, Jared D., Greish, Yaser E.
• Primary Examiner(s): Edwards; N.
• Application Number:
  US10/938,493
• Publication Number:
  US 20050112349A1
• Time in Patent Office: 1,019 Days
• Field of Search: 623/11.11, 623/23.74, 428/364, 428/36.3, 606/139, 606/222
• US Class Current: 428/364
• CPC Class Codes: A61L 2400/12 Nanosized materials, e.g. nanofibres, nanoparticles, nanowires, nanotubes; Nanostructured surfaces
• CPC Class Codes: A61L 27/18 obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
• CPC Class Codes: A61L 27/50 Materials characterised by their function or physical properties , e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
• CPC Class Codes: A61L 31/10 Macromolecular materials
• CPC Class Codes: C08L 85/02 containing phosphorus
• CPC Class Codes: Y10T 428/1369 Fiber or fibers wound around each other or into a self-sustaining shape [e.g., yarn, braid, fibers shaped around a core, etc.]
• CPC Class Codes: Y10T 428/249924 Noninterengaged fiber-containing paper-free web or sheet which is not of specified porosity
• CPC Class Codes: Y10T 428/2913 Rod, strand, filament or fiber

Abstract

Polymeric nanofibers have been developed which are useful in a variety of medical and other applications, such as filtration devices, medical prosthesis, scaffolds for tissue engineering, wound dressings, controlled drug delivery systems, cosmetic skin masks, and protective clothing. These can be formed of any of a variety of different polymers, either non-degradable or degradable. In a preferred embodiment demonstrated in the following examples, nanofibers are formed of biodegradable and non biodegradable polyphosphazenes, their blends with other polyphosphazenes or with organic, inorganic/organometallic polymers as well as composite nanofibers of polyphosphazenes with nanosized particles such as hydroxyapatites.

Claims

1. A device comprising biocompatible polymeric nanofibers having a diameter of between 100 and 1000 nm, wherein the device is selected from the group consisting of a medical device, sutures, drug delivery device, matrix or scaffold for tissue engineering, repair or regeneration device, medical prosthesis, or cosmetic skin mask, and wherein the polymer has the formula shown below:

2. The device of claim 1, wherein the nanofibers further comprise a polymer selected from the group of nondegradable polymers consisting of nylon, polyurethane, polycarbonate, polyacrylonitrile, polyethyleneoxide, polyaniline, polyvinyl carbazole, polystyrene and poly(vinyl phenol) and the group of biodegradable polymers consisting of polyhydroxyacids, poly(caprolactone, polyanhydrides, polyhydroxyalkanoates, polyurethanes, collagen, alginate, chitosan, and hyaluronic acid, and blends and copolymers thereof.

3. The device of claim 1 wherein the nanofibers are formed of non-biodegradable or biodegradable polyphosphazenes, blends of polyphosphazenes with a biodegradable organic polymer, or composite nanofibers of polyphosphazene and nanocrystals or nanosized particles.

4. The device of claim 1, wherein the nanofibers further comprise particles selected from the group consisting of hydroxyapatite, structural materials, buffering materials, and drug particles.

5. The device of claim 1 wherin the nanofibers are formed from a polymer solution having a concentration of 6—

9% in an organic solvent.

6. The device of claim 1 wherin the nanofibers form a wrap knitted mesh, woven mesh, or nonwoven mesh.

7. The device of claim 1, wherein the device is a suture.

8. The device of claim 1, wherein the device is a drug delivery device, further comprising a drug or biologically active agent.

9. The device of claim 1 wherein the medical device is selected from the group comprising general surgical mesh, hernia mesh, pericardial patch, anti-adhesion patch, cardiovascular patch, guided tissue regeneration patch, sling, monofilament suture, multifilament suture, braid, ligament, tendon, nerve guide, vascular graft, and dura.

10. The device of claim 1 wherein the nanofibers are monofilaments, multifilaments, or braided structures.