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Method of selectively determining glycated hemoglobin

  • US 7,235,378 B2
  • Filed: 07/12/2001
  • Issued: 06/26/2007
  • Est. Priority Date: 07/14/2000
  • Status: Expired
First Claim
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1. A method of determining an amount of glycated hemoglobin in a sample comprising glycated hemoglobin and glycated albumin from whole blood, comprising:

  • selectively degrading the glycated hemoglobin in the sample with a protease to give a glycated hemoglobin degradation product;

    reacting a glycation site of the glycated hemoglobin degradation product and a fructosyl amino acid oxidoreductase in a redox reaction;

    determining a product produced by the redox reaction; and

    correlating the amount of the product produced with the amount of glycated hemoglobin in the sample.

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