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Yeast cells engineered to produce pheromone system protein surrogates, and uses therefor

  • US 7,235,648 B1
  • Filed: 02/26/1999
  • Issued: 06/26/2007
  • Est. Priority Date: 03/31/1993
  • Status: Expired due to Fees
First Claim
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1. A yeast cell having a pheromone system, which cell comprises:

  • (a) a first heterologous gene encoding a heterologous surrogate of a yeast pheromone receptor, said surrogate performing in the pheromone system of the yeast cell a function naturally performed by said yeast pheromone receptor, and (b) a second heterologous gene encoding a heterologous peptide, wherein said heterologous peptide modulates the interaction of said surrogate with said pheromone system in the yeast cell, and said modulation is a selectable or screenable event, and wherein said heterologous peptide is selected from the group consisting of agonists for the surrogate receptor and antagonists of the surrogate receptor.

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