Modification of medical prostheses
First Claim
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1. A method of coating at least a portion of a medical device with a therapeutic agent comprising the steps of:
- forming a first composition by combining at least the following;
a therapeutic agent,an acidic component,a matrix component selected from the group consisting of hide powder, collagen, gelatin, cartilage, tendon, ligament, bone, keratin, fibrin, albumin, globulin, hydroxylapatite, and any combination thereof; and
,glycerol;
applying said first composition to at least a portion of said medical device to form a first layer;
forming a second composition comprising a cyanoacrylate; and
,applying said second composition on said first layer to form a second layer.
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Abstract
The incorporation of one or more therapeutic agents on metallic and non-metallic medical prostheses is provided. The therapeutic agent can be used, for example, to prevent, treat, or reduce bacterial and fungal infections associated with these implants. Additionally, the therapeutic agents can be used to effect other therapeutic benefits. Specifically, a bilayer therapeutic coating is applied in two steps. Additionally, non-antimicrobial therapeutic agents may be incorporated in this coating to treat, prevent, modify, or stimulate certain clinical bioactivities.
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Citations
41 Claims
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1. A method of coating at least a portion of a medical device with a therapeutic agent comprising the steps of:
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forming a first composition by combining at least the following; a therapeutic agent, an acidic component, a matrix component selected from the group consisting of hide powder, collagen, gelatin, cartilage, tendon, ligament, bone, keratin, fibrin, albumin, globulin, hydroxylapatite, and any combination thereof; and
,glycerol; applying said first composition to at least a portion of said medical device to form a first layer; forming a second composition comprising a cyanoacrylate; and
,applying said second composition on said first layer to form a second layer. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26)
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27. An implantable medical device comprising:
a body having one or more surfaces; a first coating on at least a portion of said body, said first coating comprising; glycerol, a therapeutic agent, an acidic component, and; a matrix component selected from the group consisting of hide powder, collagen, gelatin, cartilage, tendon, ligament, bone, keratin, fibrin, albumin, globulin, hydroxylapatite, and any combination thereof; a second coating on at least a portion of said first coating, said second coating comprising a cyanoacrylate. - View Dependent Claims (28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41)
Specification