Compliant tissue sealants

• US 7,238,364 B2
• Filed: 01/07/2003
• Issued: 07/03/2007
• Est. Priority Date: 03/23/1995
• Status: Expired due to Fees

• Current Assignee: Genzyme Corporation (Sanofi )
• Original Assignee: Genzyme Corporation (Sanofi )
• Inventors: Sawhney, Amarpreet S., Jarrett, Peter K., Lyman, Michelle D., Rudowsky, Ronald S.
• Primary Examiner(s): Nutter; Nathan M.
• Application Number:
  US10/338,933
• Publication Number:
  US 20030104032A1
• Time in Patent Office: 1,638 Days
• Field of Search: 424/426, 424/489, 424/490, 528/354, 528/361, 525/54.1, 525/54.2, 525/406, 525/413, 525/415, 514/772.1
• US Class Current: 424/426
• CPC Class Codes: A61K 9/1635 obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
• CPC Class Codes: A61K 9/1647 Polyesters, e.g. poly(lactide-co-glycolide)
• CPC Class Codes: A61L 24/0042 Materials resorbable by the body
• CPC Class Codes: A61L 24/046 obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds A61L24/043 takes precedence
• CPC Class Codes: A61L 26/0019 obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
• CPC Class Codes: A61L 31/06 obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds A61L31/041 takes precedence
• CPC Class Codes: A61L 31/10 Macromolecular materials
• CPC Class Codes: A61L 31/148 Materials at least partially resorbable by the body
• CPC Class Codes: C08G 63/64 Polyesters containing both carboxylic ester groups and carbonate groups
• CPC Class Codes: C08G 63/676 in which at least one of the two components contains aliphatic unsaturation
• CPC Class Codes: C08L 67/04 Polyesters derived from hydroxycarboxylic acids, e.g. lactones C08L67/06 takes precedence

Abstract

An improved barrier or drug delivery system which is highly adherent to the surface to which it is applied is disclosed, along with methods for making the barrier. In the preferred embodiment, the system is compliant, in that it is capable of conforming to the three dimensional structure of a tissue surface as the tissue bends and deforms during healing processes. The barrier or drug delivery systems is formed as a polymeric coating on tissue surfaces by applied a polymerizable monomer to the surface, and then polymerizing the monomer. The polymerized compliant coating preferably is biodegradable and biocompatible, and can be designed with selected properties of compliancy and elasticity for different surgical and therapeutic applications.

Claims

1. A method for reducing leakage of bodily fluids or air, comprising applying to an appropriate area of the body a solution containing a biodegradable, biocompatible polymerizable monomer and an initiator therefore;

and polymerizing the solution to seal the body area with a polymer coating.

2. The method of claim 1, wherein the solution is applied to a retinal detachment.

3. The method of claim 2, wherein the monomer is photopolymerized.

4. The method of claim 2, wherein the monomer comprises at least two photopolymerizable groups and at least one degradable region separating the photopolymerizable groups.

5. The method of claim 4, wherein the monomer further comprises a water soluble region.

6. The method of claim 5, wherein the water soluble block is selected from the group consisting of poly(ethylene glycol), poly (ethylene oxide), poly(vinyl alcohol), poly(vinylpyrrolidone), poly(ethyloxazoline), polysaccharides, and proteins.

7. The method of claim 4, wherein the degradable region is selected from the group consisting of poly(hydroxyl acids), poly(amino acids), polycarbonates, poly(anhydrides), poly(orthoesters), poly(phosphazenes), and poly(phosphoesters).

8. The method of claim 4, wherein the polymerizable groups are selected from the group consisting of vinyl groups, allyl groups, cinnamates, acrylates, dimethacrylates, and oligomethoacrylates.

9. The method of claim 6, wherein the water soluble region is poly(ethylene glycol).

10. The method of claim 9, wherein the poly(ethylene glycol) has a molecular weight of at least about 3,000 g/mol.

11. The method of claim 10, wherein the poly(ethylene glycol) has a molecular weight of at least about 10,000 g/mol.

12. The method of claim 2, further comprising applying at least one photoinitiator to the retinal surface.

13. The method of claim 12, wherein the photoinitiator is cosin Y.

14. The method of claim 2, wherein the polymer solution further comprises more than one initiator.

15. The method of claim 2, wherein the polymer solution further comprises a co-monomer.

16. The method of claim 15, wherein the monomer comprises poly(ethylene glycol) terminated with caprolactone and capped with acrylic acid.

17. The method of claim 16, wherein the co-monomer is selected from the group consisting of N-vinyl pyrrolidone, N-vinyl acetamide, N-vinyl imidazole, N-vinyl caprolactam, and N-vinyl formamide.