Nucleic acid binding compounds containing pyrazolo[3,4-d]pyrimidine analogues of purin-2,6-diamine and their uses
First Claim
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1. A nucleic acid binding compound comprising a backbone, said backbone having attached one or more heterocyclic groups capable of base pairing to nucleobases, wherein at least one heterocyclic group is a group of formula I:
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Abstract
The present invention is in the field of nucleic acid binding compounds comprising 7-substituted 7-deaza-8aza-2,6-diamino-purine bases, compounds useful for the preparation of such compounds, various uses thereof and methods for the determination of nucleic acids using said compounds in the field of diagnostics.
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30 Claims
- 1. A nucleic acid binding compound comprising a backbone, said backbone having attached one or more heterocyclic groups capable of base pairing to nucleobases, wherein at least one heterocyclic group is a group of formula I:
- 14. A composition for analyzing interactions between nucleic acid binding compounds comprising an array of a plurality of nucleic acid binding compounds having different sequences, said plurality of nucleic acid binding compounds being coupled to a solid substrate at known locations and selected to bind to complementary nucleic acid binding compounds, wherein the nucleic acid binding compounds comprise a backbone, said backbone having attached heterocyclic groups capable of base pairing to nucleobases, and wherein at least one heterocyclic group is a 7-iodo- or 7-bromo-substituted pyrazolo[3,4-d]pyrimidine or an analogue thereof.
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