Brain function measurement device, brain function measurement method, and brain function measurement program

• US 7,239,903 B2
• Filed: 12/03/2004
• Issued: 07/03/2007
• Est. Priority Date: 06/07/2004
• Status: Expired due to Fees

• Current Assignee: National Institute of Information and Communications Technology
• Original Assignee: National Institute of Information and Communications Technology
• Inventors: Eda, Hideo
• Primary Examiner(s): WINAKUR, ERIC FRANK
• Application Number:
  US11/003,827
• Publication Number:
  US 20050272988A1
• Time in Patent Office: 942 Days
• Field of Search: 600/323, 600/326, 600/328, 600/473, 600/476, 600/310
• US Class Current: 600/310
• CPC Class Codes: A61B 2562/0233 Special features of optical sensors or probes classified in A61B5/00
• CPC Class Codes: A61B 2562/046 in a matrix array
• CPC Class Codes: A61B 5/14553 specially adapted for cerebral tissue

Abstract

In addition to irradiating examination light toward the inside of the bead of the subject and detecting the examination light reflected from the head: structural data indicating the head structure, wherein the head is divided into multiple materials and the various materials are further divided into multiple elements, are stored in a structural data storage unit set up in a specified region of memory; the optical properties of the aforementioned elements are calculated from a given specified initial value; the hemodynamics inside the brain of the subject are calculated based on the optical properties thereof, and the aforementioned initial values are taken to be the optical properties when the light intensity signal values, provisionally calculated from optical properties under the assumption that the optical properties are uniform for each of the aforementioned materials, are in a fixed range of the actually measured light intensity signal values.

Claims

1. A brain function measurement device, which uses a light irradiation unit that irradiates examination light toward the inside of a head of a subject, and a light receiving unit that receives the examination light exiting from the head and outputs light intensity signals indicating a light intensity thereof comprising:

a structural data storage unit that stores structural data indicating a head structure wherein the head is divided into multiple materials, and the various materials are further divided into multiple elements;

an optical properties and hemoglobin parameters calculator that calculates optical properties of the aforementioned elements from predetermined initial values that differs between the various materials, and calculates the hemoglobin parameters inside the brain of the subject based on the optical property values thereof; and

an initial values calculator that calculates the aforementioned initial values,

characterized in that the initial values calculator thereof provisionally stipulates the optical property values of the various materials under the assumption that the optical properties are uniform for each material, and takes the aforementioned initial values to be the accepted optical properties when the light intensity signal values calculated from these provisional optical properties are in a fixed range of the actually measured light intensity signal values.

2. A brain function measurement device according to claim 1 in which the aforementioned initial values calculator successively updates the aforementioned accepted optical properties by taking the predetermined initial values input into the initial values calculator as a point of departure such that the light intensity signal values calculated based on these predetermined initial values approach the aforementioned actually measured light intensity signal values.

3. A brain function measurement device according to claim 1 in which the aforementioned structural data classifies the head into five materials of a scalp, skull, CSF, gray matter, and white matter.

4. A brain function measurement device according to claim 1 in which the aforementioned structural data is obtained by actual measurements of the head of the subject.

5. A brain function measurement device according to claim 1 in which the aforementioned structural data is taken to be what is commonly obtained from a general model.

6. A brain function measurement device according to claim 1 in which the aforementioned examination light is near infrared light of specified multiple wavelengths.

7. A brain function measurement method comprising the steps of:

irradiating light using light irradiation means to irradiate examination light toward an inside of a head of a subject;

receiving light using light receiving means to receive examination light exiting from the head, and to output light intensity signals that indicate a light intensity thereof;

storing structural data via storage in a structural data storage unit set up in a specified region of memory, the structural data indicating a head structure wherein the head is divided into multiple materials, and then the various materials are further divided into multiple elements;

calculating the optical properties of the various aforementioned elements from predetermined initial values that differ between the various materials, and calculating the hemoglobin parameters in a brain of the subject based on the optical properties thereof; and

calculating initial values by taking the predetermined initial values to be the accepted optical properties when the optical intensities calculated from the optical properties, provisionally stipulated under the assumption that the optical properties are uniform for each material, are in a fixed range of the actually measured light intensity signal values.

8. A brain function measurement method according to claim 7 wherein the aforementioned initial values calculation step is conducted such that the light intensity signal values calculated based on the aforementioned accepted optical properties approach the actually measured light intensity signal values, and such that the predetermined initial values are re-calculated by successively updating the predetermined values input as a point of departure.

9. A computer readable storage medium storing a brain function measurement program, which is executable on a computer that uses a light irradiation unit that irradiates examination light toward the inside of the head of the subject, and a light receiving unit that receives the examination light exiting from the head and outputs light intensity signals indicating the light intensity thereof, characterized in that a computer executing the proaram performs the functions of:

a structural data storage unit that stores structural data indicating the head structure wherein the head is divided into multiple materials, and the various materials are further divided into multiple elements;

an optical properties and hemoglobin parameters calculator that calculates optical properties of the aforementioned elements from predetermined initial values that differ between the various materials, and calculates the hemoglobin parameters inside the brain of the subject based on the optical properties thereof; and

an initial values calculator that provisionally stipulates the optical properties of the various materials under the assumption that the optical properties are uniform for each material, and that takes the aforementioned initial values to be the accepted optical properties when the light intensity signal values calculated from these provisional optical properties are in a fixed range of the actually measured light intensity signal values.

10. A brain function measurement program according to claim 9 in which the aforementioned initial values calculator successively updates the aforementioned accepted optical properties by taking predetermined values input into the initial values calculator as a point of departure such that the light intensity signal values calculated, based on these values, approach the aforementioned actually measured light intensity signal values.

11. A brain function measurement device for measuring functional activity of an in vivo brain, comprising:

a light irradiation unit for irradiating selective positions of the brain by directing light of predetermined wavelengths into a head of a living subject;

a light receiving unit for detecting the light of predetermined wavelengths of the light irradiation unit after interaction with the head of the living subject and providing light detection signals;

a structural data storage unit storing a predetermined set of structural data representative of a head of a type of the living subject including a plurality of data elements for each of a scalp, a bone, a brain white matter, a brain gray matter and cerebrospinal fluid, the data for each of the plurality of data elements includes an absorption coefficient and a reduced scattering coefficient that differ between the various materials; and

a computer system for

(a) receiving the light detection signals from the light receiving unit and coordinating each light detection signal with the data elements and storing the coordinated light detection signals in a light intensity storage unit,

(b) processing the light detection signals with the predetermined set of structural data for each of the plurality of data elements to determine the hemoglobin parameters of the living subject brain,

(c) one of (i) modifying the predetermined set of structural data in the structural data storage unit when the hemoglobin parameters are beyond a predetermined range, and (ii) outputting the hemoglobin parameters when the hemoglobin parameters are within the predetermined range, and

(d) repeating the irradiation, detection and processing of the light detection signals until the hemoglobin parameters of the living subject brain are within the predetermined range.